A system for monitoring an approach to a target includes a luminal device including a distal portion, a sensor coupled to the distal portion of the luminal device, and a surgical instrument including one or more indicators having a detectable property located along at least a portion of the surgical instrument. The luminal device is configured to be inserted into a patient, and the distal portion of the luminal device is configured to be guided proximate a target. The sensor is configured to sense the detectable property of the one or more indicators. The surgical instrument is configured to be guided through the luminal device.

An arrangement that enables performing of both magnetic particle imaging and magnetic resonance imaging and a device including the arrangement are provided. The arrangement that enables performance of both magnetic particle imaging and magnetic resonance imaging includes: at least one primary magnetic element pair configured to generate a selection magnetic field (SMF1/SMF2) for magnetic particle imaging, at least one secondary magnetic element pair configured to generate a driving magnetic field, and at least one tertiary magnetic element pair configured to generate a focus magnetic field (FMF).

The described embodiments relate to a method for analyzing a sample volume including magnetic particles. The method may include applying an electric excitation signal to a measuring coil so as to generate a magnetic field acting on the sample volume using the measuring coil. Furthermore, the method may include sensing an electric measurement signal dependent on the inductance of the measuring coil and analyzing magnetic permeability of the sample volume using the measurement signal.

A hybrid imaging apparatus for imaging an object to be examined located in a sample volume can be operated in an MPI mode and in at least one further imaging mode and comprises a magnet arrangement embodied to generate, in the MPI mode, a magnetic field with a gradient B1 and a field-free region in the sample volume, wherein the magnet arrangement comprises a ring magnet pair with two ring magnets in a Halbach dipole configuration, which are arranged coaxially on a common Z-axis that extends through the sample volume, wherein the ring magnets are arranged so as to be twistable relative to one another about the Z-axis. Consequently, it is possible to generate magnetic fields that meet the requirements of both MRI and MPI such that the hybrid imaging apparatus can be equipped for measurements in various imaging modes, including MPI, MRI and CT.

A hybrid imaging apparatus for imaging an object to be examined located in a sample volume can be operated in an MPI mode and in at least one further imaging mode and comprises a magnet arrangement embodied to generate, in the MPI mode, a magnetic field with a gradient B1 and a field-free region in the sample volume, wherein the magnet arrangement comprises a ring magnet pair with two ring magnets in a Halbach dipole configuration, which are arranged coaxially on a common Z-axis that extends through the sample volume, wherein the ring magnets are arranged so as to be twistable relative to one another about the Z-axis. Consequently, it is possible to generate magnetic fields that meet the requirements of both MRI and MPI such that the hybrid imaging apparatus can be equipped for measurements in various imaging modes, including MPI, MRI and CT.

A hysteresis effect-based Field Free Point-Magnetic Particle Imaging (FFP-MPI) method includes the following steps: acquiring a hysteresis loop model of Superparamagnetic Iron Oxide Nanoparticles (SPIOs); calculating to obtain a Point Spread Function (PSF) of the SPIOs on the basis of a sinusoidal excitation magnetic field and the hysteresis loop model of the SPIOs; acquiring an original reconstructed image of FFP-MPI on the basis an FFP moving track and a voltage signal; performing deconvolution on the original image with respect to the PSF considering an hysteresis effect, so as to obtain a final reconstructed image; the artifacts and phase errors of image reconstruction caused by the hysteresis effect of the SPIOs with large particle sizes are reduced, the deficiency in reconstruction by the traditional reconstruction method that ignores the hysteresis effect is overcome, the reconstruction speed and the resolution are greatly improved, and the application range of the SPIOs is expanded.

A hysteresis effect-based Field Free Point-Magnetic Particle Imaging (FFP-MPI) method includes the following steps: acquiring a hysteresis loop model of Superparamagnetic Iron Oxide Nanoparticles (SPIOs); calculating to obtain a Point Spread Function (PSF) of the SPIOs on the basis of a sinusoidal excitation magnetic field and the hysteresis loop model of the SPIOs; acquiring an original reconstructed image of FFP-MPI on the basis an FFP moving track and a voltage signal; performing deconvolution on the original image with respect to the PSF considering an hysteresis effect, so as to obtain a final reconstructed image; the artifacts and phase errors of image reconstruction caused by the hysteresis effect of the SPIOs with large particle sizes are reduced, the deficiency in reconstruction by the traditional reconstruction method that ignores the hysteresis effect is overcome, the reconstruction speed and the resolution are greatly improved, and the application range of the SPIOs is expanded.

This application provides a preparation method of a heating fluid used for biological targeted hyperthermia, a heating fluid preparation device, a biological targeted hyperthermia apparatus, and a control method of the biological targeted hyperthermia, in which the biological targeted hyperthermia apparatus includes: a heating fluid injection device configured to inject a heating fluid into a body circulatory system of a therapy subject; a microwave radiation device configured to provide microwave radiation with a set wavelength and a set frequency; a microwave imaging temperature-measuring device configured to detect a temperature and a position of the heating fluid in the therapy subject, and output a thermal imaging signal; and a control device used for receiving the thermal imaging signal and controlling the microwave radiation device to output the microwave radiation with the set wavelength and the set frequency.

The present disclosure belongs to a field of biomedical imaging technology, and in particularly to a non-uniform excitation field-based method and system for performing a magnetic nanoparticle imaging. The present disclosure includes: separating the non-uniform excitation field into independent space and current time functions by a spatialtemporal separation method; calculating a normalized signal peak through the current time function; constructing a reconstruction mathematical model based on the normalized signal peak and an imaging subunit volume; and quantitatively reconstructing a spatial distribution of a nanoparticle by combining the normalized signal peak, a non-uniform spatial function of the excitation field and the reconstruction mathematical model, so as to achieve the magnetic nanoparticle imaging of a to-be-reconstructed object.

The present disclosure belongs to a field of biomedical imaging technology, and in particularly to a non-uniform excitation field-based method and system for performing a magnetic nanoparticle imaging. The present disclosure includes: separating the non-uniform excitation field into independent space and current time functions by a spatialtemporal separation method; calculating a normalized signal peak through the current time function; constructing a reconstruction mathematical model based on the normalized signal peak and an imaging subunit volume; and quantitatively reconstructing a spatial distribution of a nanoparticle by combining the normalized signal peak, a non-uniform spatial function of the excitation field and the reconstruction mathematical model, so as to achieve the magnetic nanoparticle imaging of a to-be-reconstructed object.