The present invention is directed to a miniaturized biosensor and nanotechnology which is embedded in a variety of medical devices which can be used for real-time device location tracking and analysis, for the purpose of optimizing device positioning both at the time of initial placement and throughout its clinical use (i.e., device continuum). The continuously acquired device-specific standardized data is then transmitted through wireless communication networks to provide continuous feedback and alerts to authorized clinical providers as to device positioning, clinical performance, and presence of pathology.

Provided herein are compositions for the ingestible administration of lisinopril. In some embodiments the compositions comprise lisinopril and silicon. In some embodiments, the compositions comprise lisinopril, silicon, magnesium metal, and copper (I) chloride. Also provided herein are apparatuses comprising the compositions provided herein. Also provided herein are methods for using the compositions and apparatuses provided herein.

Gastric resident electronics, devices, systems, and related methods are generally provided. Some embodiments comprise administering (e.g., orally) an (electronic) resident structure to a subject (e.g., a patient) such that the (electronic) resident structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before exiting said location internal to the subject. In some embodiments, the resident structure is a gastric resident electronic. That is to say, in some embodiments, the resident structure is configured for relatively long gastric residence and comprises an electronic component. In some embodiments, the structures and components described herein may comprise one or more components configured for the delivery of an active substance(s) (e.g., a pharmaceutical agent) to the subject. In some embodiments, the device has a modular design, combining an electronic component(s) with materials configured for controlled and/or tunable degradation/dissolution to determine the time at which (gastric) residence is lost and the device exits the location internal to the subject. For example, in some embodiments, the resident structure comprises an electronic component and one or more additional components associated with the electronic component such that the resident structure is configured to be retained at a location internal to a subject for greater than or equal to 24 hours.

A capsule endoscope according to one embodiment includes: a camera; a transceiver; a tubular receiving coil for receiving power supplied from an external power transmitting antenna via magnetic flux; a tubular capsule accommodating these components; and an X-ray marker to be used in location and orientation detection. In the capsule endoscope, a magnetic body is arranged along the inner periphery of the receiving coil, and a self-propelling drive device including an electromagnet and a permanent magnet is arranged in series with the receiving coil along the tubular axial direction of the capsule so that the permanent magnet does not enter the inside of the receiving coil.

The current disclosure relates to methods and devices for measuring concentrations of analytes in the gastrointestinal tract of a subject by orally administering a smart pill to the subject, the smart pill comprising two or more sensors, a reference electrode, a power source, a communication interface and electronic circuits, each sensor being able to measure an analyte in the gastrointestinal tract of said subject, wherein the two or more sensors measure different analytes, measuring a concentration of two or more analytes using the two or more sensors, wherein one of the sensors is a pH sensor for measuring hydrogen ions, and wherein the pH sensor is able to locate the smart pill in the gastrointestinal tract by correlating the measured hydrogen ion concentration to a location in the gastrointestinal tract, and transmitting, using the communication interface, the measured concentrations from the two or more sensors to a base device located outside of the body of the subject.

An endoscopy auxiliary device includes an insertion tube and a clamping unit. The clamping unit has a pipe and a connector. The connector is connected to the insertion tube. The tube is configured to clamp a capsule endoscopy. The pipe has an inner space configured to accommodate a part of the capsule endoscopy. The pipe includes a first slit, a second slit and a third slit. The first slit extends from a free end of the pipe for a first distance toward a connection end of the pipe. The second slit extends from the free end of the pipe for the connection distance toward the connection end of the pipe. The third slit extends from the free end of the pipe for a third distance toward the connection end of the pipe. The first slit, the second slit and the third slit are separated from each other.

Apparatus is provided that includes a drug capsule containing an oral drug, and a sensing apparatus that includes a housing and a sensor. The housing is shaped so as to define exactly one hemispherical portion and exactly one cylindrical portion, which together define an internal surface tightly fitted to at least a portion of an external surface of the drug capsule. The sensor includes first and second electrodes, which comprise first and second electrode surfaces, respectively; and circuitry, which (a) is attached to the housing, (b) is electrically coupled to the first and the second electrode surfaces, and (c) is configured to drive a current between the first and the second electrode surfaces. Other embodiments are also described.

An apparatus and method apply magnetic fields by generators external to a body or body part with sensors within an in vivo source that are sensitive to applied magnetic fields Through the use of these applied magnetic fields and sensitive sensors, disclosed embodiments can realize much better spatial resolution than is conventionally possible.

A capsule device configured to navigate through a patient's GI track is disclosed. System and method to turn on the capsule device based on acceleration is described. First the capsule is monitored at a slow sampling mode. Then the capsule is monitored at a fast sampling mode. A user can input hand motion to change the acceleration to turn on the capsule device.

A helix antenna structure includes loop antennas and a multilayered printed circuit board including printed circuit board layers. Each printed circuit board layer includes a peripheral loop antenna and each adjacent two loop antennas are electrically connected by a connection bridge functioning as a monopole antenna. A selected printed circuit board layer physically and electrically accommodates a transmitter inside ‘its’ peripheral loop antenna, and it further includes a first antenna feeding line which is connected to the loop antenna that is disposed on the selected printed circuit board layer and electrically connectable to a first output terminal of the transmitter. A second antenna feeding line is disposed on another printed circuit board layer and electrically connected to its loop antenna and connectable to another output terminal of the transmitter. The two antenna feeding lines lie in a plane perpendicular to an axis of the printed circuit board after its folding.