In at least one embodiment of a device configured for insertion into a gastrointestinal tract of the present disclosure, the device comprises a core comprising a core material which is solid, semi-solid or compressible, one or more sensors embedded in an interior of the device and/or on a surface of the device, at least one of the one or more sensors configured to obtain a pressure measurement within the gastrointestinal tract and during defecation of the device, and a plurality of electrodes within or upon the device and configured to obtain impedance planimetric measurements within the gastrointestinal tract and during defecation of the device, the impedance planimetric measurements useful to determine cross-sectional areas.

A method, including: transmitting, by a first circuit to outside a user's body, information related to a first medication ingested by the user, the first circuit being digestible by gastric juices of the user, the first circuit being covered by a first thickness of a first digestible material; and transmitting, by a second circuit to outside the user's body, information related to a second medication ingested by the user, the second circuit being digestible by the gastric juices of the user, the second circuit being covered by a second thickness of a second digestible material and the first thickness of the first digestible material.

A position detection system includes: a capsule medical device configured to generate a position-detecting magnetic field; a plurality of detection coils arranged outside a subject; and a processor including hardware. The processor is configured to correct a magnetic field component caused by a first magnetic field generation material with respect to each of measurement values of detection signals output from the detection coils, the first magnetic field generation material being arranged inside a space that the position-detecting magnetic field generated by the capsule medical device present inside a detection target region is reachable, the detection target region being a region in which a position of the capsule medical device is detectable, the first magnetic field generation material being configured to generate a magnetic field due to action of the position-detecting magnetic field.

Aspects disclosed in the detailed description include an ingestible power harvesting device and related applications. An ingestible power harvesting device includes a cathode electrode and an anode electrode that can catalyze a power generating reaction to generate a direct current (DC) power when surrounded by an acidic electrolyte. The cathode electrode and the anode electrode are coupled to an encapsulated electronic device that includes power harvesting circuitry configured to harvest the DC power and output a DC supply voltage for a prolonged period. In examples discussed herein, the prolonged period is at least five days. The DC supply voltage powers an electronic circuit in the encapsulated electronic device to support a defined in vivo operation (e.g., controlled drug delivery, in vivo vital signs monitoring, etc.). As such, the ingestible power harvesting device can operate in vivo for the prolonged period without requiring an embedded conventional battery.

In-vivo devices, systems and methods for the detection of blood within in-vivo bodily fluids. The methods include irradiating in-vivo fluids passing through a gap in a housing of an in-vivo device introduced to the GI tract of a subject with a plurality of illumination sources positioned on a first side of a gap; detecting with at least one light detector positioned on the opposite side of the gap and facing the illumination sources, light irradiated by the illumination sources; transmitting a plurality of values representing the light detected over time; converting these values to blood concentration values over time, and comparing the blood concentration values to a predetermined threshold value. Based on the comparison, the method includes determining the type of bleeding profile, such that if a plurality of blood concentration values measured consecutively is above the threshold value, the bleeding profile indicates bleeding.

A system and method are provided for securing an ingestible electronic device to a pharmaceutical product without damaging the ingestible electronic device. The product includes the ingestible electronic device being placed on the product in accordance with one aspect of the present invention, in accordance with another aspect of the present invention, the ingestible electronic device is placed inside the product. Various embodiments are disclosed in accordance with the present invention for protecting and/or coating of the electronic marker as well as securing the ingestible electronic device onto the product.

Various embodiments are described herein for a device, system, and method for identifying a location of an ingestible device within a gastrointestinal tract of a body. In some embodiments, the ingestible device includes a sensing unit with an axial optical sensing sub-unit located proximal to at least one end of the device, and a radial optical sensing sub-unit located proximal to a radial wall of the device, and may autonomously identify a location within the gastrointestinal tract. In some embodiments, the ingestible device includes optical illumination sources and detectors that operate at a plurality of different wavelengths, and may discern regions of a gastrointestinal tract by using the reflection properties of organ tissue and occasional particulates. In some embodiments, the ingestible device may sample fluid or release medicament based on a detected device location.

Disclosed is a radio antenna comprising a substrate of dielectric material; a ground plane of electrically conductive material on a first face of the substrate; a resonator for converting an incident electrical signal into an electromagnetic wave and for resonating at at least two different resonant frequencies. The resonator comprises at least three elements, each in the form of strips of conductive material and arranged on a second face of the substrate opposite the first face. A second element is electrically connected to the ground plane by means of a via passing through the substrate at a first end of the corresponding strip, forms an extension of the first element, and is electrically connected directly to the first element at a second end of said strip which is opposite the first end.

A gas permeable, liquid impermeable membrane for use with gas sensors consists of a film forming polymer which incorporates nanoparticles selected to improve one or more of the following: permeability to gases, to selectively regulate permeability of selected gases through the membrane, to inhibit microbial growth on the membrane. A capsule shaped container consists of wall material biocompatible with a mammal GI tract and adapted to protect the electronic and sensor devices in the capsule, which contains gas composition sensors, pressure and temperature sensors, a microcontroller, a power source and a wireless transmission device. The microprocessor receives data signals from the sensors and converts the signals into gas composition and concentration data and temperature and pressure data for transmission to an external computing device. The capsule wall incorporates gas permeable nano-composite membranes with embedded catalytic and nano void producing nanoparticles, enhancing the operation, selectivity and sensitivity of the gas sensors.

This special gut microbe and chemical substance sampling technology, utilizing swallowable capsules, is for purpose of determining roles gut contents play in some 52 of most costly, in lives and dollars, of diseases with their known origin in the human gut. Gut microbes and substances are collected, analyzed, medicinal substances and objects deployed, and special provisions for attracting, capturing and preserving certain strains of microbes, and means for perturbing the gut environment and immune system are all intended to research, discover, and ultimately find both the causes and cures for the most devastating human diseases, and in the process, create gut microbiome profiles.