The present disclosure relates to a method for continuous and noninvasive estimation of mixed venous blood saturation [SvO2] in a mechanically ventilated subject (3). The method comprises the steps of measuring (S1; S10) an expiratory carbon dioxide [CO2] content in expiration gas exhaled by the subject, measuring (S2; S20) an expiratory flow or volume of expiration gas exhaled by the subject, estimating (S3; S30) a cardiac output [CO] or an effective pulmonary blood flow [EPBF] of the subject from the measured expiratory CO2 content and the measured expiratory flow or volume using a capnodynamic Fick method, and estimating (S4; S40) SvO2 based on the estimated CO or the EPBF of the subject.

Disclosed herein are devices, systems, and methods for updating alarm limits applied in monitoring one or more medical parameters of a subject. The devices, systems, and methods obtain a measurement of ambient pressure at a defined time point (‘t.sub.1’) and compare the measurement of ambient pressure at the defined time point (‘t.sub.1’) to a reference ambient pressure. If a difference between the measured ambient pressure values at t.sub.1 and the reference ambient pressure is at or above a predetermined threshold, the alarm limits are updated to correspond with the ambient pressure at t.sub.1 or a user is alerted to update the alarm limits.

To provide a mask capable of reducing a load of a patient while suppressing lowering of accuracy at which a subject's exhaled air is measured. A mask to be put on a subject's face includes a mask body portion demarcating an internal space in a state of covering part of the subject's face and a cup-shaped nasal cup covering a subject's nose in a state of being arranged inside the internal space, in which the nasal cup includes a first wall portion covering the subject's nose, a second wall portion arranged under the subject's nostrils, and an exhaled air discharge portion guiding an exhaled air from the subject's nose to an exhaled air sensor, and at least part of the exhaled air from the subject's nose is guided toward the exhaled air discharge portion by the second guide portion in a state where the nasal cup covers the subject's nose.

Various systems, devices, components, and methods are disclosed for measuring the concentration of an analyte, such as acetone, in a breath sample. The disclosed devices include a breath sample analysis device having a mouthpiece configured to facilitate engagement with a user's mouth to receive a breath sample. The disclosed devices also include a breath sample capture cartridge containing an interactant that extracts the analyte from a breath sample passed through the cartridge. Also disclosed are devices for routing the breath sample through the cartridge during exhalation, and for analyzing a reaction in the cartridge to measure a concentration of the analyte.

Systems and methods for evaluating patients are provided. An example includes receiving first cardiopulmonary exercise test data for the patient and plotting a first vector based on the first cardiopulmonary exercise test data, the first vector including a first point based on a rest value and a second point based on an exercise value. A first coordinate value of the first point and a first coordinate value of the second point may be based on mixed expired CO.sub.2 (PECO.sub.2) and a second coordinate value of the first point and a second coordinate value of the second point may be based on end tidal CO.sub.2 (PetCO.sub.2). The example may also include plotting a midpoint of the first vector and triggering display of the plotted vector and plotted midpoint. The plotted vector and plotted midpoint may be displayed over a coordinate grid having multiple physiological condition zones.

A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system in a high flow therapy system, the gas delivery conduit includes a first connector adapted for connecting to the respiratory gases delivery system, a second connector adapted for connecting to a fitting of a patient interface, tubing fluidly connecting the first connector to the second connector where the first connector has a gas inlet adapted to receive the supplied respiratory gas, one of electrical contacts and temperature contacts integrated into the first connector. The gas delivery conduit further can include a sensing conduit integrated into the gas delivery conduit, where the first connector of the gas delivery conduit is adapted to allow the user to couple the first connector with the respiratory gases delivery system in a single motion.

Disclosed is a breath sampling device comprising a buffer tube, sensor module and breath sampling port. The buffer tube has a proximal end into which a user exhales and a distal end opposite the proximal end, the sensor module is at the distal end and used for measuring parameters of a breath exhaled by the user into the buffer tube, and the breath sampling port is disposed between the proximal end and distal end. The used exhales into the distal end and a portion of the exhaled breath can be diverted into the sampling port substantially without contacting the sensor module.

The invention relates to a breath test system that is unobtrusive in that it does not require a person subjected to the system to take any other action to breath. It comprises a sensor unit (5) configured to sense the presence or concentration of a volatile substance, present in air flowing through a predefined inlet area (4), and to generate a signal corresponding to the concentration of said substance. There is also provided an apparatus (2, 3) configured to detect the presence of a person at a position in the vicinity of said input area, and having means for registering said presence, and further configured to respond to said presence by delivering an output. This said apparatus includes a unit configured to call for immediate attention of said person, upon said registration of the presence of said person, and a unit configured to provide instructions to said person to direct an expiratory air flow towards said inlet area (4). An analyzer (10) for the determination of breath substance concentration of said person is also provided, the determination being based on said signal corresponding to the substance concentration.

A healthcare device for asthmatic patients that can help in reducing and avoiding risk factors that can trigger one or more symptoms of asthma. The healthcare device includes an infrared sensor, a pulse oximeter sensor, a UV sensor, an atmospheric sensor, and an air quality sensor for measuring values of different risk factors including ambient temperature, body temperature, blood oxygen saturation level, heart rate, intensity of ultraviolet radiations, humidity level, altitude, CO2 levels, and total volatile organic compounds (TVOCs).

A method of treating a human subject which is effected by inhalation of gaseous nitric oxide, the method comprising a first treatment period comprising administering gNO by inhalation over a period of about at least 5 days, wherein the first treatment period is followed by a second treatment period comprising administering gNO by inhalation over a period of at least 3 months. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract.