A method and system are disclosed for use in monitoring/screening/diagnosing sleep or wake state of a subject or patient. The method generally includes monitoring the patient's activity during one or more sleep sessions comprising a plurality of intervals known as epochs. The sleep/wake state of the subject is determined during each epoch of the session using actigraphy data obtained during the monitoring session. The actigraphy data provides information about the activity of a patient during an epoch. The sleep or wake state is determined based on a ratio of the activity count during an epoch to the activity count during a preceding epoch. If the ratio is greater than a first activity threshold, then a “wake” indication may be provided by, for example, the system. Alternatively, or additionally, a “wake” indication may be determined if the activity count during the epoch is greater than a threshold.

The invention relates to a spirometer (1) comprising a MEMS-based thermal fluid flow sensor (13, 13.1, 13.2) for generating a signal in response to a fluid flow generated during inhalation or exhalation; and a microcontroller (14) for calculating the fluid flow from the signal generated by the flow sensor (13, 13.1, 13.2). The spirometer (1) may be connected to other devices, such as a smartphone or a personal computer or any other computing unit which is adapted to collect, store, analyse, exchange and/or display data. The invention further describes the use of the spirometer (1) in measuring a user's lung performance and/or monitoring it over time. Furthermore, the spirometer (1) may be provided in a system together with an air quality measurement device for determining the air quality at a location of interest; and a computing unit for collecting, analysing and correlating the user's lung performance data obtained from the spirometer (1) with the air quality data, and optionally geolocalisation data of said location.

A non-invasive method and system is provided for determining an internal component of respiratory effort of a subject in a respiratory study. Both a thoracic signal (T) and an abdomen signal (A) are obtained, which are indicators of a thoracic component and an abdominal component of the respiratory effort, respectively. A first parameter of a respiratory model is determined from the obtained thoracic signal (T) and the abdomen signal (A). The first parameter is an estimated parameter of the respiratory model that is not directly measured during the study. The internal component of the respiratory effort is determined based at least on the determined first parameter of the respiratory model. The first model parameter is determined based on the thorax signal (T) and the obtained abdomen signal (A) without an invasive measurement.

An oral appliance includes an upper arch and a seal. The upper arch may be positioned proximate a maxillary dentition of a user. The upper arch includes a first tab and a second tab positioned on opposite sides of a plane substantially bisecting the upper arch. The seal defines a first receptacle and a second receptacle that may receive the first and second tabs to couple the seal to the upper arch and to inhibit breathing through a mouth of the user.

An oral appliance includes an upper arch and a seal. The upper arch may be positioned proximate a maxillary dentition of a user. The upper arch includes a first tab and a second tab positioned on opposite sides of a plane substantially bisecting the upper arch. The seal defines a first receptacle and a second receptacle that may receive the first and second tabs to couple the seal to the upper arch and to inhibit breathing through a mouth of the user.

The present invention provides for a data acquisition system for EEG and other physiological conditions, preferably wireless, and method of using such system. The wireless EEG system can be used in a number of applications including both studies and clinical work. These include both clinical and research sleep studies, alertness studies, emergency brain monitoring, and any other tests or studies where a subject's or patient's EEG reading is required or helpful. This system includes a number of features, which enhance this system over other systems presently in the marketplace. These features include but are not limited to the having multiple channels for looking at a number of physiological features of the subject or patient, a built in accelerometer for looking at a subject's or patient's body motion, a removable memory for data buffering and storage, capability of operating below 2.0 GHz, which among other things allows for more channels, movement artifact correction including video, pressure sensors capable of measuring or determining airflow, tidal volume and ventilation rate, and capability of manual and automatic RF sweep.

The present invention provides for a data acquisition system for EEG and other physiological conditions, preferably wireless, and method of using such system. The wireless EEG system can be used in a number of applications including both studies and clinical work. These include both clinical and research sleep studies, alertness studies, emergency brain monitoring, and any other tests or studies where a subject's or patient's EEG reading is required or helpful. This system includes a number of features, which enhance this system over other systems presently in the marketplace. These features include but are not limited to the having multiple channels for looking at a number of physiological features of the subject or patient, a built in accelerometer for looking at a subject's or patient's body motion, a removable memory for data buffering and storage, capability of operating below 2.0 GHz, which among other things allows for more channels, movement artifact correction including video, pressure sensors capable of measuring or determining airflow, tidal volume and ventilation rate, and capability of manual and automatic RF sweep.

A processing device in one embodiment is configured to generate a first sound cue of a first type, the first sound cue comprising a primary entrainment cue for an entrainment sonification system, to generate one or more additional sound cues of a second type, each of the one or more additional sound cues comprising an auxiliary entrainment cue for the entrainment sonification system, to provide the first sound cue and the one or more additional sound cues to one or more audio devices of the entrainment sonification system for generation of sound for audible presentation to a user, to receive from one or more sensors of the entrainment sonification system one or more feedback signals, and to adjust one or more characteristics of at least one of the first sound cue and the one or more additional sound cues based at least in part on the one or more received feedback signals.

A processing device in one embodiment is configured to generate a first sound cue of a first type, the first sound cue comprising a primary entrainment cue for an entrainment sonification system, to generate one or more additional sound cues of a second type, each of the one or more additional sound cues comprising an auxiliary entrainment cue for the entrainment sonification system, to provide the first sound cue and the one or more additional sound cues to one or more audio devices of the entrainment sonification system for generation of sound for audible presentation to a user, to receive from one or more sensors of the entrainment sonification system one or more feedback signals, and to adjust one or more characteristics of at least one of the first sound cue and the one or more additional sound cues based at least in part on the one or more received feedback signals.

Methods of lowering heart rate during physical activity for a user in need of an increase in their smallest concentric airway cross-sectional area include providing the person with a mandibular repositioning device having a maxillary tooth covering having a driver flange protruding laterally outward on a right and left side proximate a backmost teeth mold and a mandibular tooth covering having a protrusive flange extending cranially therefrom positioned to have a posterior side engaged with the anterior side of each driver flange. The anterior side of each driver flange has a convex curvature, and the posterior side of each protrusive flange has a concave-to-convex curvature from its base toward its most cranial point and a convex portion of the concave-to convex curvature engages the convex curvature of the driver flange in a rest position, and downward movement of the mandibular piece moves the user's mandible forward as well.