A fluid aspiration probe apparatus for automatic fluid testing equipment includes a pair of electrodes mounted on a distal probe tip. The electrodes are coupled to an impedance measurement apparatus via conductive pathways along the probe. The impedance measurements and probe tip height are monitored as the probe tip is lowered into a fluid sample. Boundaries between layers of fluid in the container are detected by recognizing sudden changes in the impedance measurements and heights of the boundaries are determined by tracking the position of probe tip when the sudden changes of impedance occur.

An apparatus for estimating bio-information includes an optical sensor including a light source configured to emit light of multiple wavelengths onto an object, and including a plurality of detectors configured to detect light of each wavelength which is scattered or reflected from the object. The apparatus includes a processor configured to obtain spectra based on light of each wavelength which is detected by each detector, determine valid spectra of the obtained spectra, and estimate a bio-information value based on the valid spectra.

A non-invasive method and apparatus utilizing a single wavelength (800 nm, isobestic) for the instantaneous, reflective, non-pulsatile spatially resolved reflectance system, apparatus and mathematics that allows for the correct determination of critical photo-optical parameters in vivo. Transcutaneous blood constituent (analyte or drug level) measurements can be determined in real-time. The “closed-form” nature of the mathematics with inclusion of other wavelengths (660 nm and 1300 nm) and a non-invasive transmissive array allows for immediate calculation and real-time display of Hematocrit, Hemoglobin, fractional tissue blood volume (Xb), Hematocrit-Independent Oxygen Saturation, fractional tissue water content (Xw) and other pertinent blood/plasma values in a variety of handheld or other like devices.

A device and method of using the device to detect the presence and composition of clots and other target objects in a circulatory vessel of a living subject is described. In particular, devices and methods of detecting the presence and composition of clots and other target objects in a circulatory vessel of a living subject using in vivo photoacoustic flow cytometry techniques is described.

A blood-purification-treatment support system is capable of making an accurate judgement of whether or not any treatment conditions for blood purification treatment should be changed. The blood-purification-treatment support system is capable of supporting blood purification treatment. The system includes a storage device that stores patient-specific patient data that are acquired on a plurality of days including at least no-treatment days on which blood purification treatment is not conducted, an estimating device that compares the patient data for the plurality of days stored in the storage device with one another and estimates a pre-treatment patient state regarding blood purification treatment, and a judging device that judges from the pre-treatment patient state estimated by the estimating device whether or not any treatment conditions for blood purification treatment should be changed.

A system for monitoring percentage change in blood volume (ΔBV %) during dialysis treatment includes a sensor device configured to obtain hematocrit (Hct)-related measurements based on detecting light which has passed through extracorporeal blood of a patient undergoing the dialysis treatment; one or more controllers configured to: determine Hct values based on the Hct-related measurements obtained by the sensor device; determine ΔBV % values based on the determined Hct values; and generate a GUI having a ΔBV % plot based on the determined ΔBV % values; and a display device having a display configured to display the GUI having the ΔBV % plot. Zone indicators are provided on the display to distinguish between a first zone corresponding to a first ΔBV % profile, a second zone corresponding to a second ΔBV % profile, and a third zone corresponding to a third ΔBV % profile.

The present disclosure provides materials and methods for the continuous measurement of biomolecules in vivo and in real-time. The present disclosure relates more specifically to using capture agents and detection agents within a microfluidic device to detect and quantify biochemical features of biomarkers, enabling real-time detection and concentration measurements.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

Apparatuses, systems, and techniques are described to detect one or more biological conditions. In one or more implementations, the presence of anemia can be detected in individuals. A wearable device can collect data regarding amounts of attenuation of electromagnetic radiation having one or more wavelength ranges. The amounts of attenuation of the electromagnetic radiation can be used to determine measures of biomolecules and the measures of biomolecules can be used to determine probabilities of individuals being diagnosed with anemia. Additionally, one or more implementations of a computational platform can facilitate the exchange of information between healthcare practitioners and patients regarding the diagnosis and treatment of one or more biological conditions. The computational platform can also analyze large amounts of information to generate computational models to determine probabilities of individuals being diagnosed with anemia and to determine candidate treatments for anemia.

Systems and methods for non-invasive blood pressure measurement are disclosed. In some embodiments, a system comprises a wearable member configured to generate first and second signals, and a blood pressure calculation system. The blood pressure calculation system a pre-processing module configured to filter noise from the signals, and a wave selection module configured to identify subsets of waves of the signals, a feature extraction module configured to generate sets of feature vectors form the subsets of waves, and a blood pressure processing module configured to calculate an arterial blood pressure value based on the sets of feature vectors and an empirical blood pressure calculation model, the empirical blood pressure calculation model configured to receive the sets of feature vectors as input values. The blood pressure calculation system further includes a communication module configured to provide a message including or being based on the arterial blood pressure value.