An electronic system for bioimpedance signal acquisition, comprises: a current signal injection module configured for generating a current signal to be applied to a subject; a bioimpedance signal measurement module configured for measuring a bioimpedance signal based on a voltage generated by the current signal; a data quality detection module configured for detecting an AC or a DC level of the measured bioimpedance signal and detecting whether the AC or DC level is within or outside an AC reference value range and a DC reference value range, respectively; and a signal adaptation module configured for modifying at least one parameter of the current signal injection module or the bioimpedance signal measurement module based on said detection of the AC or DC level in relation to the AC reference value range and the DC reference value range, respectively.

A pseudo-resistor structure, comprises: a first and a second PMOS transistor or PN diode configured as two-terminal devices, wherein the positive terminal of the first PMOS transistor or PN diode is connected to the positive terminal of the second PMOS transistor or PN diode, and wherein the negative terminal of the first PMOS transistor or PN diode is connected to an input (A) of the pseudo-resistor structure and wherein the negative terminal of the second PMOS transistor or PN diode is connected to an output (C) of the pseudo-resistor structure, and a dummy transistor or dummy diode connected to the input (A), wherein the dummy transistor or dummy diode is further connected to a bias voltage for compensating a leakage current through the first and the second PMOS transistors or PN diodes. A closed-loop operational amplifier circuit comprising the pseudo-resistor structure is provided. Also, a bio-potential sensor comprising the closed-loop operational amplifier circuit is provided.

A textile-based hydrogel electrode comprises a textile-based backing layer, a conductive structure coupled to the textile-based backing layer, and a hydrogel body in contact with at least a first portion of the conductive structure, wherein the first portion of the conductive structure and the hydrogel body form an ionic interface configured to generate an electrical signal through the conductive structure corresponding to a biopotential change proximate to the textile-based hydrogel electrode.

An apparatus for measuring intracranial dynamics comprises the at least one sensing device (100): an electroencephalo-graphic electrode arrangement, which senses direct-current electroencephalographic signals from the brain, an optic measurement Marrangement (120), which directs optic radiation toward the brain through the cranium, and receives the optic radiation reflected and/or scattered therefrom, and/or a capacitive sensor arrangement (130), which senses electric potential signals of the head. The apparatus additionally comprises a data processing arrangement (150), which receives electric signals from the at least one sensing device (100), and determine data on at least one of the following dynamics: glymphatic activity, water within the cranium, brain tissue movements, water and/or electrolyte movements and intracranial pressure based on said electric signals from the at least one sensing device (100). The data processing arrangement (150) then outputs at least one piece of the data on the dynamics through a user interface (152).

The present invention provides systems and methods for detection and diagnosis of concussion and/or acute neurologic injury comprising a portable headwear-based electrode array and computerized control system to automatically and accurately detect cortical spreading depression and acute neurological injury-based peri-infarct depolarization (CSD/PID). The portable headwear-based electrode system is applied to a patient or athlete, and is capable of performing an assessment automatically and with minimal user input. The user display indicates the presence of CSD/PID, gauges its severity and location, and stores the information for future use by medical professionals. The systems and methods of the invention use an instrumented DC-coupled electrode/amplifier array which performs real-time data analysis using unique algorithms to produce a voltage intensity-map revealing the temporally propagating wave depressed voltage across the scalp that originates from a CSD/PID on the brain surface.

A method and system are described for, based upon a plurality of previously-acquired directional LFP signals measured in a plurality of different directions at a directional sensor lead located in a predetermined region of a patient's brain, determining optimised patient-specific programming parameters for programming a directional stimulation lead with parameters for stimulating the said region. The method comprises a first step of determining, over at least one predetermined frequency range, a power-frequency variation curve of each of the directional LFP signals, a second step of identifying frequency peaks in the power-frequency variation curves, a third step of detecting one of the identified frequency peaks at which a maximum difference in signal power between the directional LFP signals occurs, and a fourth step of calculating a plurality of directional stimulation weighting factors on the basis of the relative signal powers of the directional LFP signals at the detected frequency peak.

A method for evaluating operational performance of a biological system and apparatus for fetching data required therefor are disclosed. The apparatus includes an emitting unit, an electric potential measuring unit, an analog-to-digital converting unit, and an operating unit. The present invention utilizes excitation of external signal light beams to fetch changed data of electric potential from the skin surface, further to observe the status of the organs inside the living creature's body. In comparison with traditional technologies, such as X-ray and nuclear magnetic resonance, the present invention has advantages of short observation time, low operating cost, and harmless to the living creature.

An apparatus is used in a therapeutic process to provide relief of pain and swelling by dynamic electric stimulation at very low power levels at frequencies between about 2 to 100 Hz. in which the stimulation frequency is constantly offset from the detected dominant frequency by between about 2 to 20 Hz. The pain relief benefits can last weeks, even though the treatment duration is generally well under a minute.

Methods and systems for optimizing invasive and noninvasive brain stimulation are described herein. In a particular embodiment, methods and systems for a combinatorial, iterative approach to modify behavior are presented wherein deep brain stimulation (DBS) and other brain stimulation therapies are implemented in combination with monitoring the brain activity of an individual to optimize the effectiveness of the combinatorial approach to modify behavior. Methods described herein are iterative and systems described herein are utilized in iterative fashion. In a particular embodiment, modifying behavior provides a therapy for an individual in need thereof.

The present invention relates to a system and method useful for determining the voltage of biological tissues and therefore to detect whether such tissues are cancerous.