The present invention provides an eating monitoring method for judging whether chewing is performed or not by a chewing judgment algorithm on the basis of a temporal variation in a measured value of a sensor unit configured to detect a movement of a jaw while a person takes a meal, the person wearing a detection device comprising the sensor unit. The method includes the steps of: adjusting the chewing judgment algorithm on the basis of a variation in a measured value of the sensor unit, the variation corresponding to a chewing action or a mouth opening/closing action of the person wearing the detection device; and judging whether chewing is performed or not by the chewing judgment algorithm which has been adjusted, and measuring the number of chews on the basis of a temporal variation in a measured value of the sensor unit during the meal.

A wearable computing device for monitoring and facilitating prescription adherence by a patient is provided. The wearable computing device is in communication with an inventory management server. The wearable computing device includes a processor and a memory. The processor is configured to receive a set of prescription plan data including at least a prescription identifier and a prescription rate associated with the prescription identifier. The processor is further configured to determine an inventory level associated with the prescription identifier. The processor is also configured to determine, based at least on the prescription rate, a time value representing a period of time in which a patient is prescribed to take a pharmaceutical associated with the prescription identifier. The processor is additionally configured to present a prescription inventory indicator representing the inventory level. The processor is also configured to present a timer indicator representing the time value.

A pharmaceutical product including a housing that defines a cavity, wherein the cavity stores a pharmaceutical material, and wherein the housing comprises a material configured to dissolve based on contact with a fluid, an ingestible device to encode information in a current signature, wherein the ingestible device is positioned within the housing, and a protective material that encompasses the ingestible device. The ingestible device may be attached to a flexible component, wherein the flexible component is configured to releasably secure the ingestible device within the housing.

An injection sensing device (ISD) (e.g., wearable patch) is paired with an external device (e.g., a medication delivery pen and/or smart phone, iPad, computer) via wireless link or wireline connection. The ISD senses fluctuations in local skin temperature during an injection and provides to the external device captured data from the sensor relating to medicine delivery to a patient to ensure complete delivery and minimize MDD misuse or malfunction or inaccuracies in dosing. The ISD or external device can use captured data and corresponding time stamps to determine flow informatics such as flow rate, total dose delivered, and dose completion status. An LED on the ISD indicates delivery in progress and/or delivery completion.

Systems and methods for monitoring eyedrop usage are disclosed. Example embodiments include a system to monitor eyedrop usage. The system may include a detection and activation circuit couplable to a wireless biosensor and an eyedrop dispenser. The detection and activation circuit may include a pressure transducer that transmits a signal upon detecting a force at, or above, a threshold value. The system may also include a wireless biosensor insertable into a region of an eyelid. The wireless biosensor may include a sensor to detect the physical change and the chemical change of tears as a result of eyedrop usage. The wireless biosensor may also include a transceiver to receive the signal that activates the sensor for an activation time.

Apparatus, systems, and methods are provided for generating a quantified indicator of cognitive skills in an individual. In certain configurations, the apparatus, systems, and methods can be implemented for enhancing cognitive skills in an individual.

A system and method for measuring the effectiveness of a dose from an inhaler on a user is disclosed. The inhaler includes a drug container and a dosing mechanism coupled to the drug container to aerate a dose from the drug container. The dosing mechanism provides the aerated dose to the user. A sensor interface is in communication with a physiological sensor. The physiological sensor is attached to a user to sense a physiological response to the dose. Physiological data is sent to the sensor interface. A controller is coupled to the sensor interface to collect the sensed physiological data from the user corresponding to the time that the aerated dose is delivered to the user. The effectiveness of the dose may be determined from the collected data. The dose amount or frequency may be changed or the drug may be changed based on the collected data.

A wearable medication adherence monitoring (MAM) device for wearing by a patient, including an operating unit (OU) which includes: a wireless communications unit (WCU); a processing unit (CPU); a memory unit; and one or a plurality of peripheral interface(s) with a plurality of input peripherals; and further includes the plurality of input peripherals and output peripherals in a MAM unit (MAMU) which includes: an interactive visual display unit (VDU) including a visual display (VD) and a VD patient interaction (PI) tool (VDTOOL); and an interactive audio platform (AP) including an audio output unit (SPK) and an audio PI tool (MIC; and one or a plurality of sensor unit(s) (SU(s)) including at least one biomarker sensor, and optionally at least one biometric sensor; included in one or a plurality of attachment units (AU) for wearing of the device on or about a body part of the patient.

Recombinant adeno associated viral vectors are disclosed. These include AAV8 or AAV9 derived vectors that include capsid proteins with mutations that confer upon the vector particular characteristics such as the ability to transduce or avoid (detarget) particular tissues, to be retained longer in the blood, or to be internalized in a cell without viral expression.

A medical vast and using method thereof. The medical vest has a clothe capable of surrounding the chest of a user's body, one or more vibration devices located in the clothe respectively and a motion sensor located in the clothe. Hence, when a user wears the medical vest and/or when the user actives one or more vibration devices to apply a net vibration force to the users' chest, the motion sensor may detect the user's real posture and/or both the vibration intensity and/or the vibration frequency of the vibration force applied to the user's chest. Accordingly, the user may adjust the vibration intensity and/or the vibration frequency of one or more vibration devices, also may adjust how the clothe is worn on the user's chest.