The present invention provides methods of monitoring and measuring tumor-associated free PSA (“fPSA”) with antibody polypeptides as an indication of androgen receptor signaling. In a particular embodiment, the methods may be used to assess the efficacy of anti-androgen and/or general anti-cancer treatments. The present invention also provides various methods and compositions relating to antibodies that are specific for tumor-associated or intratumoral fPSA. For example, the present invention provides compositions, including pharmaceutical compositions, comprising anti-fPSA antibodies, or fragments or characterisitic portions thereof. The present invention further provides various therapeutic and/or diagnostic methods of using anti-fPSA antibodies and/or compositions.

The present disclosure contains embodiments of an apparatus, system and method designed to facilitate learning or efficient multitasking involving movement and solar energy where users' movement devices process or respond to different stimuli to facilitate users moving while learning, working, or participating in a simulation. In some embodiments this may be accomplished with the aid of a circular treadmill, spherical walkway, or combinable modular trackpads that may be linked to allow a user to lay the apparatus in a path suited for a plurality of environments. The embodiments of the disclosure involve the user moving while processing information and receiving feedback, assistance related to that movement, processing, or any combination thereof while combining the motion of the movement device with the feedback loop sent from sensor relays a user may receive an optimal experience for learning while moving. Some embodiments make efficient use of solar energy for classroom education management.

Systems, devices and methods for managing personal activities and health regimens are provided. In some aspects, a control system comprising specialized computer hardware and software provides instruction(s), warning(s), penalty(ies), encouragement(s) and incentive(s) to a user, based on such a health regimen. In additional aspects, such instruction(s), warning(s), penalty(ies), encouragement(s) and incentive(s) are also based on data from specialized sensors tracking a user's personal activities within a personal activity space. In some aspects, instruction(s), warning(s), penalty(ies), encouragement(s) and incentive(s) are adjusted in real time, based on input from multiple users. In one example, a partial giveback reward is provided to a user, in which part of a regimen goal that is exceeded is provided back to the user as one such incentive.

Infusion devices and related medical devices, patient data management systems, and methods are provided for monitoring a physiological condition of a patient. An exemplary infusion device includes an actuation arrangement operable to deliver fluid to a user, a communications interface to receive measurement data indicative of a physiological condition of the user, a sensing arrangement to obtain contextual measurement data, and a control system coupled to the actuation arrangement, the communications interface and the sensing arrangement to determine a command for autonomously operating the actuation arrangement in a manner that is influenced by the measurement data and the contextual measurement data and autonomously operate the actuation arrangement in accordance with the command to deliver the fluid to the user.

A method for determining the average usage of an analyte monitoring system may include the step of calculating one or more analyte measurements of a host during a first period of time. The method may include the step of calculating a duration of time that the host uses the analyte monitoring system during the first period of time. The method may include the step of calculating an average time that the host uses the analyte monitoring system during a second period of time or a percentage of the first period of time that the host uses the analyte monitoring system, in which the average time or the percentage is calculated based on at least the calculated duration. The method may include the step of generating and displaying a report indicating the average time or the percentage.

A method for determining the average usage of an analyte monitoring system may include the step of calculating one or more analyte measurements of a host during a first period of time. The method may include the step of calculating a duration of time that the host uses the analyte monitoring system during the first period of time. The method may include the step of calculating an average time that the host uses the analyte monitoring system during a second period of time or a percentage of the first period of time that the host uses the analyte monitoring system, in which the average time or the percentage is calculated based on at least the calculated duration. The method may include the step of generating and displaying a report indicating the average time or the percentage.

Provided herein are systems and methods for monitoring one or more health or physiological parameters in a subject. The systems and methods may comprise a patch coupled to an injector. Data may be transmitted to a mobile device or remote server, where the data may be processed. Processed data may be used to inform a subject on a health or physiological condition.

A mechanical ventilation device comprising at least one electronic controller configured to receive imaging data and transpulmonary pressure data associated with a lung of a patient; perform deformable image registration of the inhalation image and the exhalation image to produce a relative compliance or elasticity map of the lungs; convert the relative compliance or elasticity map of the lungs to a quantitative compliance or elasticity map of the lungs based on the inhale transpulmonary pressure and the exhale transpulmonary pressure; and display the information relating to or derived from the quantitative compliance or elasticity map on a display device.

A pharmaceutical product including a housing that defines a cavity, wherein the cavity stores a pharmaceutical material, and wherein the housing comprises a material configured to dissolve based on contact with a fluid, an ingestible device to encode information in a current signature, wherein the ingestible device is positioned within the housing, and a protective material that encompasses the ingestible device. The ingestible device may be attached to a flexible component, wherein the flexible component is configured to releasably secure the ingestible device within the housing.

A system includes a respiratory therapy device, a sensor, and a control system. The respiratory therapy device supplies pressurized air to an airway of a user during a plurality of sleep sessions. The sensor generates data including current data that is associated with a current sleep session of the plurality of sleep sessions and historical data that is associated with one or more prior sleep sessions of the plurality of sleep sessions. The control system includes one or more processors configured to execute machine-readable instructions to: analyze the historical data to determine a behavior pattern associated with the user; analyze the current data to determine a condition of the user interface in relation to the user; and generate an alarm based at least in part on the behavior pattern associated with the user and the condition of the user interface in relation to the user.