An oral appliance includes an upper arched frame, an upper moldable tray coupled to the upper arched frame, a lower arched frame, and a lower moldable tray coupled to the lower arched frame. The upper arched frame includes a first tab and a second tab being positioned, with respect to each other, on opposite sides of a plane substantially bisecting the upper arched frame. The lower arched frame includes a third tab extending from the lower arched frame.

An inhaler includes a mouthpiece cover, a pressure sensor, a first indicator and a second indicator. The first indicator may be configured to indicate based on a state of the cover, and the second indicator may be configured to indicate based on an output of the pressure sensor. For example, when the mouthpiece cover opens, the first indicator may illuminate and a dose of medication may be transferred from a reservoir to a dosing cup. The second indicator may illuminate if an amount of inhaled medication reaches a predetermined threshold for successful inhalation.

A monitoring system for obtaining a video related to medication adherence of a user, includes: a wireless communication device comprising a motion sensor, an ambient light sensor, a first transceiver transmitting data to an external device, and a first controller configured to control the motion sensor, the ambient light sensor, and the first transceiver, the wireless communication device having an attaching portion for being attached to an object containing a medication; and a wearable device including a camera, a second transceiver receiving a signal from the first transceiver, and a second controller configured to obtain video data through the camera based on the signal received through the second transceiver.

The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can be used in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.

A transparent orthodontic appliance remote monitoring system comprises a clear aligner 100 worn on teeth for orthodontic treatment; a contact sensor module 200 installed inside the clear aligner 100 to detect wearing of the clear aligner 100 on teeth through contact therewith; a user terminal 300 that receives a signal from the contact sensor module 200 and calculates a wearing time of the clear aligner 100 from the received signal using an application, and a server computer 400 for sharing information calculated in the user terminal 300 to a clinic in charge, wherein the clear aligner 100 has a tooth insertion groove 120 into which the teeth are inserted, wherein a mounting groove 140 for mounting the contact sensor module 200 is formed on an inner surface of the tooth insertion groove 120, wherein the mounting groove 140 is formed to correspond to a tooth of the teeth with the least displacement between before and after the orthodontic treatment.

A method of treating a sleep disorder based on data and an apparatus for performing the method includes determining, by a sleep disorder treatment apparatus, sleep quality. The method and apparatus further includes determining, by the sleep disorder treatment apparatus, user compliance with a first recommended time in bed (R-TIB). The method an apparatus further includes determining, by the sleep disorder treatment apparatus, a second R-TIB on the basis of the sleep quality and the user compliance. The first R-TIB is a sleep time recommended to the user earlier, and the second R-TIB is a sleep time recommended to the user later.

A continuous and self-calibration method and system for monitoring oxygen saturation of a patient are provided. An example system includes a wearable device having a first optical sensor to measure a first red wavelength photoplethysmography (PPG) signal and a first infrared wavelength PPG signal and a second optical sensor to measure a second red wavelength PPG signal and a second infrared wavelength PPG signal. The system further includes a processor configured to repeatedly determine that conditions for recalibration of the first optical sensor are satisfied, determine a first ratio for obtaining the oxygen saturation, a first parameter for modifying the first red wavelength PPG signal, a second parameter for modifying the first infrared wavelength PPG signal, and a second ration for obtaining the oxygen saturation. The processor is further configured to determine a value of the oxygen saturation and provide a message regarding a health status of the patient.

Systems and methods for a microfluidic biosensor patch and health monitoring system may include an iontophoresis module, a multi-inlet microfluidic sweat collection and sampling module, and a molecularly imprinted polymer (MIP) organic compound sensor module. An iontophoresis module may provide for stimulation of a biofluid sample. A biofluid may be a sweat sample. Stimulation may be achieved via electrostimulation and/or application of a stimulating agent. A microfluidic sweat collection and sample module may include several adhesive layers with carefully designed inlets, channels, a reservoir, and an outlet for the efficient collection and sampling of biofluid. A MIP sensor module may quickly and accurately identify concentrations of key metabolites present in a biofluid sample which may indicate certain health conditions.

Devices, methods and systems are disclosed for assisting patients in behavioral modification and cessation programs aimed at terminating undesired behaviors such as smoking, alcohol use and others. Patient devices configured to be easily carried or worn including test units such as carbon monoxide blood level sensors with automated patient prompting for self-testing, analysis of test results and data logging are included in a networked system with a specifically designed treatment modality. Devices and methods disclosed are particularly suited to use in smoking cessation treatment and programs.

The present application provides for use of a somatosensory evoked potential (SEP) during the hyperacute stroke phase as marker for predicting the outcome of endovascular treatment in a patient suffering from acute ischemic stroke, wherein when the SEP ipsilateral to the stroke site has an amplitude from 60% to 100% with respect to the corresponding SEP contralateral to the stroke site this is indicative of good outcome of the endovascular treatment, whereas when the SEP ipsilateral to the stroke site has an amplitude from 0% to 20% with respect to the corresponding SEP contralateral to the stroke site this is indicative of bad outcome of the endovascular treatment.