The invention discloses a method for preparing Palbociclib (I). The preparation method comprises the steps of: causing a ring-closing reaction of 2-acetyl-2-butenoic acid methyl ester and malononitrile to occur in an alkaline condition to generate 1,4,5,6-tetrahydro-2-methoxyl-4-methyl-5-acetyl-6-oxy-3-pyridine carbonitrile (II); causing a substitution reaction of the intermediate(II) and halogenated cyclopentane(III) to occur under the effect of acid binding agent to generate N-cyclopentyl-1,4,5,6-tetrahydro-2-methoxyl-4-methyl-5-acetyl-6-oxy-3-pyridinecarbonitrile (IV); causing a condensation reaction of the intermediate(IV) and N-[5-(1-piperazinyl)-2-pyridinyl]guanidine (V) to occur to generate 6-acetyl-8-cyclopentyl-5,8-dihydro-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-pyrido[2,3-d]pyrimidin-7(6H)-one (VI); and causing a dehydrogenation reaction of the intermediate(VI) and sodium selenate to occur to prepare Palbociclib(I).The preparation method has readily available raw materials and a simple process, is economical and environmentally friendly, and is suitable for industrial production.

The invention discloses a method for preparing Palbociclib (I). The preparation method comprises the steps of: causing a ring-closing reaction of 2-acetyl-2-butenoic acid methyl ester and malononitrile to occur in an alkaline condition to generate 1,4,5,6-tetrahydro-2-methoxyl-4-methyl-5-acetyl-6-oxy-3-pyridine carbonitrile (II); causing a substitution reaction of the intermediate(II) and halogenated cyclopentane(III) to occur under the effect of acid binding agent to generate N-cyclopentyl-1,4,5,6-tetrahydro-2-methoxyl-4-methyl-5-acetyl-6-oxy-3-pyridinecarbonitrile (IV); causing a condensation reaction of the intermediate(IV) and N-[5-(1-piperazinyl)-2-pyridinyl]guanidine (V) to occur to generate 6-acetyl-8-cyclopentyl-5,8-dihydro-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-pyrido[2,3-d]pyrimidin-7(6H)-one (VI); and causing a dehydrogenation reaction of the intermediate(VI) and sodium selenate to occur to prepare Palbociclib(I).The preparation method has readily available raw materials and a simple process, is economical and environmentally friendly, and is suitable for industrial production.

A compound of Formula I, Formula IA, Formula IB, or Formula II, or an acid or base addition salt thereof, and use of these compounds as antioxidants. In one embodiment, a compound of Formula II, ##STR00001##
wherein each of X, Y, and Z are independently a carbon or nitrogen atom; R.sup.1 and R.sup.2 are each independently a hydrogen or an electron donating group, but are not both hydrogen, and wherein R.sup.1, and R.sup.2 are each bonded to a carbon atom in their own respective aryl ring.

A compound of Formula I, Formula IA, Formula IB, or Formula II, or an acid or base addition salt thereof, and use of these compounds as antioxidants. In one embodiment, a compound of Formula II, ##STR00001##
wherein each of X, Y, and Z are independently a carbon or nitrogen atom; R.sup.1 and R.sup.2 are each independently a hydrogen or an electron donating group, but are not both hydrogen, and wherein R.sup.1, and R.sup.2 are each bonded to a carbon atom in their own respective aryl ring.

A method for preparing a vulcanizable composition of matter, the method comprising mixing, within a first mixing step, rubber, silica, and silica coupling agent to form a first masterbatch composition, adding nicotinamide to the first masterbatch composition and mixing within a second mixing step to form a second masterbatch composition, and adding a curative to the second masterbatch composition and mixing within a final mixing step.

A method for preparing a vulcanizable composition of matter, the method comprising mixing, within a first mixing step, rubber, silica, and silica coupling agent to form a first masterbatch composition, adding nicotinamide to the first masterbatch composition and mixing within a second mixing step to form a second masterbatch composition, and adding a curative to the second masterbatch composition and mixing within a final mixing step.

Provided is an optical film which has high selective absorbability to short-wavelength visible light having wavelengths around 420 nm and hence a high blue-light cutting function and can impart better display characteristics when used for a display device. The optical film satisfies the following two formulae: (1) A(420)≧1 and (2) A(450)/A(420)≦0.3, wherein A(420) represents an absorbance of the optical film at a wavelength of 420 nm and A(450) represents an absorbance of the optical film at a wavelength of 450 nm.

Provided is an optical film which has high selective absorbability to short-wavelength visible light having wavelengths around 420 nm and hence a high blue-light cutting function and can impart better display characteristics when used for a display device. The optical film satisfies the following two formulae: (1) A(420)≧1 and (2) A(450)/A(420)≦0.3, wherein A(420) represents an absorbance of the optical film at a wavelength of 420 nm and A(450) represents an absorbance of the optical film at a wavelength of 450 nm.

The present invention relates to a formulation comprising an oxidatively curable alkyd-based resin and a chelating agent. More particularly, the formulation is essentially absent an amount of cations selected from the group consisting of manganese, iron, cobalt, vanadium and copper ions, which ions, if present in the formulation, will form together with the chelant a metal drier capable of accelerating oxidative curing. The invention also provides a method of making the formulation and a method of contacting the formulation with a composition comprising transition metal ions so as to provide a composition comprising an oxidatively curable alkyd-based resin and a complex of the transition metal ion and the chelating agent.

Polyolefin photovoltaic (PV) backsheets comprise a polypropylene layer stabilized with (A) at least one hindered amine with 2,2,6,6-tetraalkylpiperdine or 2,2,6,6-tetraakylpiperazinone, either or both in combination with a triazine moiety, (B) a thioester, and, optionally, (C) at least one hindered hydroxybenzoate, and/or (D) an ortho hydroxyl triazine compound. These PV backsheets exhibit a low flame spread index of <100 without the use of FR agents, and the polypropylene layer exhibits good weatherability while providing the required long term heat aging performance necessary for PV modules.