A noninvasive, brain cooling method and device for cerebral cooling via a patient's nasopharyngeal cavity, is described. Thermal conductive nasal prongs are inserted into a nasal cavity and are cooled by thermoelectric cooling elements. An outward air driving fan inside the device drives a cold air current through the nasal and oral cavities. Heat transfer between the cold air and the surface of the nasal cavity cools the nasal cavity, which in turn, cools a patient's brain. Real-time temperature sensing data provides feedback for closed-loop cooling control.

Embodiments of the present invention are directed to the treatment of hypertension, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pains, asthma, pulmonary arterial hypertension, and chronic obstructive pulmonary disease by delivering of an effective amount of formulations at desired temperature to target tissue. The formulations include gases, vapors, liquids, solutions, emulsions and suspensions of one or more ingredients. The temperature may enhance safety and efficacy of the formulations for the treatments. The amounts of the formulation and/or energy are effective to injury or damage the tissues to have a benefit of symptom relive.

We report a method of treating an epileptic seizure in a patient, comprising: detecting said epileptic seizure, based on body data from said patient; and reducing a flow of blood to a brain of said patient in response to said detected seizure; wherein said reducing is effected by: increasing the parasympathetic input to said patient's heart, such as by electrically stimulating a parasympathetic nervous structure, applying cooling energy to a sympathetic nervous structure, or administering a cholinergic or a sympatho-blocking agent to said patient. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

A multi-function module is proposed. The module may be coupled to a refrigerant supply device so as to mix a composition with a refrigerant supplied from the refrigerant supply device and spray the same to the outside. The module may include a mixer configured to provide a mixing space for the refrigerant and the composition, and a combiner to be coupled to the refrigerant supply device. The module may further include a sprayer configured to spray the refrigerant into the mixing space, and an inlet configured to provide a flow path of the composition to the mixing space. The refrigerant sprayed through an outlet hole may form negative pressure at a second end of the inlet so that the composition moves to the flow path through a first end of the inlet and flows into the mixing space through the second end of the inlet.

Systems for dense phase transport of frozen and other particles to the respiratory system include a particle source, a delivery chamber for metering boluses of the particles from the source, and a transfer tube for fluidized transport of the particles to a patient interface. A controller may be provided to adjust the rate and amount of the bolus deliver to a patient to control core body temperature and for other purposes.

Disclosed is a local cooling anesthesia device for spraying a coolant on a treatment site. The local cooling anesthesia device includes a housing which forms an outward form and from which the coolant is sprayed and a spraying unit installed in the housing to spray the coolant. The device also includes a cooling temperature regulator connected to the spraying unit to apply thermal energy to the sprayed coolant for temperature regulation and a control unit connected to the cooling temperature regulator to control the cooling temperature regulator. The cooling anesthesia device has functions of measuring and regulating the temperature of the coolant, and thus can apply the coolant to the treatment site within a safe temperature range according to the purpose of treatment, thereby enabling a desired treatment purpose such as local anesthesia to be safely and rapidly accomplished without side effects such as cytoclasis.

A control unit system. The system includes a control unit which includes a control unit charging interface, at least one magnet located proximate to the control unit charging interface, at least one actuator, a detachable manifold including at least one magnet, fluidly coupled to the at least one actuator, a pump connected to the at least one actuator for causing actuation thereof, and a control system for controlling the pump, wherein the control system controls the pump to actuate the at least one actuator at least in response to a signal received by the control system. The system also includes a recharging device configured to receive the control unit, the recharging device including a reed switch, wherein when the magnet in the control unit is located proximate to the reed switch, the switch is activated.

Devices for therapeutic interaction with an Abreu brain thermal tunnel (ABTT) terminus. Such devices provide heat to or remove heat from the ABTT terminus, and may also provide heat to or remove heat from veins connected to the ABTT. Therapeutic devices for engaging with the ABTT terminus benefit from diagnostics obtained at the ABTT terminus, or from other locations on the body.

The present invention relates to a method and system for producing and delivering sterile, airless, and highly loaded ice slurry for inducing therapeutic hypothermia. The method is capable of producing and delivering ice slurry in a patient to induce hypothermia through internal and external cooling methods such as subcutaneous, intravascular, intraperitoneal, gastrointestinal, and lung methods. The method is capable of producing and delivering saline ice slurry or other phase-change slurries compatible with human tissues. Ice slurry is made by crushing, smoothing, and mixing ice slush in an airtight and self-collapsible liquid container, followed by being pumped out through flexible tubing and injection port into a patient body without air. The novel method and system are simple, and easy to use, which facilitate long term storage, immediately ready to use, and airless delivery.

Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquide.g., a liquid or airis applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis.