A holding structure for holding a plurality of containers for pharmaceutical, medical or cosmetic purposes includes a carrier having openings or receptacles for accommodating the containers. Holding devices for holding the containers are provided at the openings or receptacles. The holding devices can selectively assume two different stable positions, namely a first stable position in which the containers can be inserted without friction into the openings or receptacles and a second stable position in which the containers are held in the respective opening or receptacle by frictional engagement or by positive locking. The containers can be reliably inserted into the openings or receptacles without material abrasion. In the open insertion position of the holding devices, a large number of containers can be inserted concurrently into the openings or receptacles without high forces acting on the holding structure.

A method of filling pharmaceutical containers includes: filling a first plurality of containers, the first plurality of containers being supported by a first holder supported on a first step of a first transport and packaging container defining a first step height, the filling includes moving filling needles of a filling device to a filling needle height and dispensing a substance into each of the first plurality of containers; and filling a second plurality of containers, the second plurality of containers being supported by a second holder supported on a second step of a second transport and packaging container defining a second step height equal to the first step height, the filling includes moving the filling needles to the filling needle height and dispensing the substance into each of the second plurality of containers, the second plurality of containers differ from the first plurality of containers in at least one aspect.

A transport tray with a plurality of sleeves each configured to receive a substantially cylindrical container having a cylindrical container wall and a container bottom surface arranged orthogonally to the container wall. Each sleeve includes a top opening, a bottom opening, a sleeve wall that extends along a sleeve axis between the top opening and the bottom opening and is configured to abut at least a portion of the container wall of a respective container, and one or more support feet adjacent to the bottom opening and extending from the sleeve wall towards the sleeve axis, wherein each support foot has a bottom surface and a top surface configured to abut the container bottom surface of a respective container forming a gap between the support foot bottom surface and the container bottom surface along the sleeve axis. The one or more support feet comprise a thermally conductive polymer.

The present disclosure describes a container that includes a body having a lower surface, an upper rim, and a plurality of side walls that extend between the lower surface and the upper rim, wherein the upper rim defines an opening to an interior space of the body, a flexible cover that covers the opening of the body and is bonded to the body along the upper rim, and gas-permeable material through which gas can enter and exit the interior space of the body. The upper rim of the body is spaced apart from any of the gas-permeable material, such that the cover can be peeled away from the upper rim to expose the opening while leaving the gas-permeable material intact.

The present disclosure describes a container that includes a body having a lower surface, an upper rim, and a plurality of side walls that extend between the lower surface and the upper rim, wherein the upper rim defines an opening to an interior space of the body, a flexible cover that covers the opening of the body and is bonded to the body along the upper rim, and gas-permeable material through which gas can enter and exit the interior space of the body. The upper rim of the body is spaced apart from any of the gas-permeable material, such that the cover can be peeled away from the upper rim to expose the opening while leaving the gas-permeable material intact.

The present disclosure describes a method that includes receiving a plurality of packaging units made of glass; coating at least a portion of an outer surface of each packaging unit with low-friction coating; curing the low-friction coating applied to the outer surface of each packaging unit; receiving a container configured to store the plurality of packaging units; and arranging each packaging unit in the container with the outer surface of each packaging unit able to touch the outer surface of one or more adjacent packaging units.

The present disclosure describes a method that includes receiving a plurality of packaging units made of glass; coating at least a portion of an outer surface of each packaging unit with low-friction coating; curing the low-friction coating applied to the outer surface of each packaging unit; receiving a container configured to store the plurality of packaging units; and arranging each packaging unit in the container with the outer surface of each packaging unit able to touch the outer surface of one or more adjacent packaging units.

A torque enhancement device having torque enhancement member(s) with each having an exterior (preferably bi-symmetric or essentially bi-symmetric) surface configuration with parallel, longer side walls extending in a Y-axis direction and shorter side walls extending in an X-axis direction and corner recesses positioned between ends of adjacent longer and shorter side walls, and with some embodiments of the invention featuring a torque enhancement device having a hole extending in a Z-axis direction. A fastener assembly is also provided that includes one or more torque enhancement devices as well as methods for utilization of the torque enhancement device or utilization or assemblage of an assembly including a torque enhancement device. The surface configuration includes arrangements where there is a torque differential in one direction or the other as well as arrangements that are adapted to handle both standard fastener configurations and torque enhancement configurations with a common torque enhancement device.

A torque enhancement device having torque enhancement member(s) with each having an exterior (preferably bi-symmetric or essentially bi-symmetric) surface configuration with parallel, longer side walls extending in a Y-axis direction and shorter side walls extending in an X-axis direction and corner recesses positioned between ends of adjacent longer and shorter side walls, and with some embodiments of the invention featuring a torque enhancement device having a hole extending in a Z-axis direction. A fastener assembly is also provided that includes one or more torque enhancement devices as well as methods for utilization of the torque enhancement device or utilization or assemblage of an assembly including a torque enhancement device. The surface configuration includes arrangements where there is a torque differential in one direction or the other as well as arrangements that are adapted to handle both standard fastener configurations and torque enhancement configurations with a common torque enhancement device.

In one aspect, a combinatorial drug delivery device is provided for delivering a predetermined selection of drug components. The device includes a plurality of modules, each including: a body having an interior volume; a spike plate movably disposed in the interior volume, the spike plate having a protruding cannula and first and second ports. The device also includes a base tray which includes: a framework defining a plurality of wells, each of the wells formed to insertingly receive one of the modules; for each of the wells, first and second inlet ports formed to interface with the first and second ports of the module being received in the respective well; passageways to connect certain wells with adjacent wells to permit fluid flow therebetween. For each of the wells, the spike plate of the respective module being maintained in a stationary position with the module being inserted into the well.