Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

The present disclosure provides methods of treating cancer in a patient. The method comprises administering to the patient an effective amount of a compound of Formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, and an effective amount of an immunomodulatory agent. Also provided herein are compositions and kits for performing the methods described herein. In another aspect, the method comprises administering to the patient an effective amount of a compound of Formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, and an effective amount of radiation therapy.

The present disclosure provides methods of treating cancer in a patient. The method comprises administering to the patient an effective amount of a compound of Formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, and an effective amount of an immunomodulatory agent. Also provided herein are compositions and kits for performing the methods described herein. In another aspect, the method comprises administering to the patient an effective amount of a compound of Formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, and an effective amount of radiation therapy.

Compositions, methods, and kits useful for treating obesity conditions are provided herein. Such compositions can contain synergizing amounts of nicotinamide riboside and/or nicotinamide mononucleotide and/or nicotinic acid metabolites in combination with a flavonoid and/or one or more flavonoid derivatives, with or without resveratrol.

Compositions, methods, and kits useful for treating obesity conditions are provided herein. Such compositions can contain synergizing amounts of nicotinamide riboside and/or nicotinamide mononucleotide and/or nicotinic acid metabolites in combination with a flavonoid and/or one or more flavonoid derivatives, with or without resveratrol.

Disclosed are uses of NAD+ and/or NAD+ agonists and/or NAD+ inhibitors for preparing a preparation or a kit, and a combination preparation including T cells and NAD+ and/or NAD+ agonists and/or NAD+ inhibitors. The preparation or kit is used for regulating T cell activity, regulating the expression level of CD69 on the surface of T cells, and/or regulating the phosphorylation level in T cells, and/or treating diseases related to T cell activity.

Disclosed are uses of NAD+ and/or NAD+ agonists and/or NAD+ inhibitors for preparing a preparation or a kit, and a combination preparation including T cells and NAD+ and/or NAD+ agonists and/or NAD+ inhibitors. The preparation or kit is used for regulating T cell activity, regulating the expression level of CD69 on the surface of T cells, and/or regulating the phosphorylation level in T cells, and/or treating diseases related to T cell activity.

Provided herein are methods of treating a tumor comprising administering (i) a composition comprising an extracellular vesicle and a STING agonist, e.g., exosome encapsulating STING agonists, in combination with (ii) an IL-12 moiety.

Provided herein are methods of treating a tumor comprising administering (i) a composition comprising an extracellular vesicle and a STING agonist, e.g., exosome encapsulating STING agonists, in combination with (ii) an IL-12 moiety.