The present disclosure relates generally to materials and medical devices impregnated with antimicrobial compounds. More specifically, the materials are medical matrix materials comprising nanopores or nanochannels in which the antimicrobial compounds are disposed. In other embodiments, medical matrix materials comprises nanomaterials and antimicrobials distributed throughout the material. The materials described herein are useful for a broad spectrum of medical devices and consumer products. The present disclosure further provides methods of making the antimicrobial materials and medical devices disclosed herein.

Described herein are electrospun core-shell fibers that include (i) a central core that is electrically conductive having an exterior surface, wherein the core comprises a first polymer and an electroconductive material; (ii) a shell adjacent to the exterior surface of the core, the shell comprising a second polymer; and (iii) one or more bioactive agents in the shell. In one aspect, the fibers are electrospun fibers. Additionally, described herein are methods for making and using the core-shell fibers.

The present disclosure provides an anti-infective and anti-adhesive wound dressing based on nonspecific adhesion to bacteria, which includes a micron-sized porous membrane with polyolefin contained in its surface and does not contain any bactericide. According to the disclosure, through targeted selection of a material and surface structure of the porous membrane, nonspecific adhesion to the bacteria on the wound surface can be formed by good adaptability of its own surface energy and the structure of the porous membrane to surface energy of the bacteria, preventing the bacteria from penetrating into wound tissues and thus realizing the anti-infection for the bacteria and the anti-adhesion to the wound. Furthermore, no bactericide is required to be added, which not only reduces infection of the wound, but also weakens factors which are not conducive to wound healing, such as aggravation of inflammation caused by bacterial toxin released after bacterial rupture in traditional sterilization mechanisms.

The present disclosure relates generally to wound inserts that may include an outer layer and an inner core of biopolymers that may be used in the therapy of tunneling wounds and for facilitating wound healing. Kits for use in practicing the methods are also provided.

A wound dressing system configured to determine an exudate uptake pattern of a wound dressing is disclosed. The wound dressing system comprises a wound dressing and a monitor device. The wound dressing comprises an absorbent core layer, a proximal electrode assembly comprising a first plurality of electrodes, and a distal electrode assembly comprising a second plurality of electrodes. The monitor device of the wound dressing system is configured to detect a short-circuiting event across a primary and a secondary electrode of the first/second plurality of electrodes. Further, the monitor device is configured to indicate an exudate uptake pattern of the wound dressing based on the short-circuiting events. Thereby, an optimum or improved use of the wound dressing is enabled and facilitated. Further disclosed is a sensor pack for a wound dressing system and a method for determining an exudate uptake pattern of a wound dressing.

A wound dressing system configured to determine an exudate uptake pattern of a wound dressing is disclosed. The wound dressing system comprises a wound dressing and a monitor device. The wound dressing comprises an absorbent core layer, a proximal electrode assembly comprising a first plurality of electrodes, and a distal electrode assembly comprising a second plurality of electrodes. The monitor device of the wound dressing system is configured to detect a short-circuiting event across a primary and a secondary electrode of the first/second plurality of electrodes. Further, the monitor device is configured to indicate an exudate uptake pattern of the wound dressing based on the short-circuiting events. Thereby, an optimum or improved use of the wound dressing is enabled and facilitated. Further disclosed is a sensor pack for a wound dressing system and a method for determining an exudate uptake pattern of a wound dressing.

The invention is related to the nanofibrous wound dressing that has been developed to be used in the treatment of various types of skin wounds including chronic and acute wounds in the biomedical sector, wherein said wound dressing comprises a bioactive agent that promotes the process of wound healing.

This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phyto-pharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.

The present invention provides a hemostatic porous composite sponge comprising i) a matrix of a biomaterial; and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.

Devices for delivering a flowable tissue dressing material for treating a tissue site are described. The devices include a first zone including a first reactant, such as a polyol, and a second zone including a second reactant, such as a multi-isocyanate, which can be mixed together to form a flowable tissue dressing material. The device can also include a flowable tissue dressing material including a reacted polymer present in a carrier. Kits and methods including and/or using the devices are also described.