A surgical staple is provided. The surgical staple includes a crown having a center portion and a foldable portion, and a pair of legs extending orthogonally from the crown and configured to puncture tissue. The crown and the pair of legs are fabricated from a biodegradable metal such that biodegradation causes the center portion to separate from the foldable portion and the pair of legs, and the foldable portion and the pair of legs are absorbable within the tissue.

Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.

Disclosed is a stent with a drug coating for preventing and treating restenosis, comprising, a stent and a drug coating covering the surface of the stent. The active ingredients in the drug coating are guaiane sesquiterpene compounds P1, P2 and P3. P1 is Zedoalactone B, P2 is a stereoisomer of P1, and P3 is Zedoarondiol. Compared with an existing sirolimus eluting stent, the present drug eluting stent can inhibit the intimal hyperplasia and the inflammatory reactions of vascular walls, and promote the endothelialization of blood vessels after the stent is implanted, and thus can prevent the long-term thrombotic complications; and has the advantages of small dosage, low cost, and no toxic side effect.

A medical device and a method and process for at least partially forming a medical device, which medical device has improved physical properties. The one or more improved physical properties of the novel metal alloy can be achieved in the medical device without having to increase the bulk, volume and/or weight of the medical device.

An anchor for an embolic coil, and an embolic coil including the same are provided. The anchor for an embolic coil includes a hollow main body and a central shaft arranged in the hollow main body, wherein the hollow main body is made of a braided composite filament including a polymer filament and a first alloy filament, and the central shaft includes a second alloy filament that is a material different from the first alloy filament.

The present invention relates to the preparation methods and applications of biodegradable zinc-copper alloys, which can be applied to medical implant materials. The alloy of present invention is mainly composed of copper (1-10 wt. %), the balance of zinc and trace impurity elements. As-cast alloy ingot is homogenized and then hot processed to refine microstructure. The mechanical properties of the alloys are improved due to the refined microstructure. The alloys are capable of being further fabricated into micro-tubes, wires and plates. There are many advantages of these Zn alloys such as excellent mechanical properties, easy to process, appropriate corrosion resistance, good biocompatibility and so on, which correspondingly can be applied to many kinds of biodegradable medical implant devices. With excellent mechanical properties, good biocompatibility and degrading completely in 6-18 months, the Zn alloys meet the requirements of implant materials for mechanical properties and biosafety.

A method of using an implantable device provides an implantable device including a plurality of arcs. Each arc contains a multiplicity of links. The implantable device further includes a device closure pin, a lock-in unit attached and located between the three arcs, and a quick-release unit attached and located between three arcs. The plurality of arcs, the lock-in unit, and the release unit form a closed contour. The closed contour of the implantable device, in a rigid state is a three-dimensional shape.

The present invention relates to a medical Au—Pt—Pd alloy including Au, Pt, Pd, and inevitable impurities. The alloy has an alloy composition inside a polygon (A1-A2-A3-A4-A5-A6) surrounded by straight lines connected at point A1 (Au: 37.9 atom %, Pt: 0.1 atom %, and Pd: 62 atom %), point A2 (Au: 79.9 atom %, Pt: 0.1 atom %, and Pd: 20 atom %), point A3 (Au: 79.9 atom %, Pt: 20 atom %, and Pd: 0.1 atom %), point A4 (Au: 69.9 atom %, Pt: 30 atom %, and Pd: 0.1 atom %), point A5 (Au: 49 atom %, Pt: 30 atom %, and Pd: 21 atom %), and point A6 (Au: 39 atom %, Pt: 40 atom %, and Pd: 21 atom %) in a Au—Pt—Pd ternary state diagram. The metal structure of the alloy is optimized, and the metal structure is close to a single-phase structure, and has little precipitation of a Au-rich phase and a Pt-rich phase different in composition from a mother phase.

An endoluminal prosthesis includes an implantable scaffold and/or stent substrate which is convertible from a compressed first geometric shape to a radially dilated dimensionally stable second tubular second geometric shape, the scaffold and/or stent substrate comprising a bioresorbable zinc alloy, the zinc alloy including at least at least four alloying elements selected from the group consisting of silver (Ag) in an amount of about 1.0 wt. % to about 6.0 wt. %, manganese (Mn) in an amount of about 0.1 wt. to about 2.0 wt. %, zirconium (Zr) in an amount of about 0.05 wt. % to about 1.0 wt. %, copper (Cu) in an amount of about 0.5 wt. % to about 1.2 wt. %, and optionally titanium (Ti) in an amount of 0 to about 0.4 wt. %, with the balance of the alloy being zinc and incidental impurities.

An implantable medical device (IMD) may include an outer housing having a titanium outer surface, the titanium outer surface including a plurality of titanium atoms. A tissue growth-inhibiting layer may extend over the titanium outer surface. In some cases, the tissue growth-inhibiting layer may include a plurality of polyethylene glycol molecules, at least some of the plurality of polyethylene glycol molecules covalently bonded via an ether bond to one of the plurality of titanium atoms.