A device for generating a condensation aerosol includes (a) vaporization chamber having an upstream first inlet and a downstream outlet; (b) a heater element in the vaporization chamber between the upstream first inlet and the downstream outlet; (c) an airflow path in fluid communication with the vaporization chamber, wherein the airflow path comprises a second inlet configured to permit a substantially laminar flow of air into the airflow path, wherein the second inlet is downstream of the heater element; and (d) the device having components or apparatus on or in the device for changing air flow in the vaporization chamber. Changing the air flow in the vaporization chamber may be used to change the particle size of a condensation aerosol produced in the vaporization chamber, and/or to change the amount of visible vapor emitted from the device.

The invention relates to a nebulizer (1) comprising an aerosol generator (6), a nebulizing chamber (5) and an outlet (16), the aerosol generator (6) being designed to release an aerosol into the nebulizing chamber (5) and the outlet (16) being designed to allow the removal of the aerosol from the nebulizing chamber (5). To achieve a high output rate, a wetting surface (2) is provided in the nebulizing chamber (5).

A breath-enhanced jet nebulizer is configured with a low liquid retention reservoir and a narrow liquid delivery passage to efficiently and efficiently aerosolize small drug volumes with minimal waste. Aerosol particles are directed through aerosol passage for delivery, although larger liquid particles are directed away from the aerosol outlet and recycled to the liquid reservoir.

Nebulizer systems, apparatus, and methods are disclosed. The apparatus includes a body, a breathing gas inlet and outlet, and a barrier. The body is sized to be positioned within an adaptor of the nebulizer system. The breathing gas inlet and the breathing gas outlet are at opposite ends of the body. The barrier is coupled to the body. A plurality of holes are formed in the barrier. The plurality of holes open in a direction orthogonal to the breathing gas inlet. The system employs the apparatus in conjunction with a nebulizer and an adaptor. The method includes generating an aerosolized medicament, providing the aerosolized medicament to the adaptor, passing the aerosolized medicament through the barrier of the apparatus, providing a breathing gas to the apparatus, and flowing the aerosolized medicament and the breathing gas through the breathing gas outlet of the apparatus.

A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.

Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

An example aerosol delivery device includes a mouthpiece having an airflow outlet, and an airflow passage extending between an airflow inlet and the airflow outlet. The example aerosol delivery device further includes a housing configured to receive a cartridge that includes an aerosolizable substance and a vapor element configured to heat the aerosolizable substance, and an internal power source configured to provide electrical power. The example aerosol delivery device further includes a controller coupled to the internal power source to receive a portion of the electrical power and configured to, when the cartridge is installed at the housing, cause the vapor element of the cartridge to heat the aerosolizable substance to release an aerosol into the airflow passage during an inhalation through the airflow outlet, and a connector configured to receive power from an external source to recharge the internal power source.

The present invention provides dry powder inhaler (DPI) devices (100) for dispensing dry powder and methods for using the same. The DPI devices feature vortex mechanisms for directing air in a turbulent manner sufficient to entrain an amount of a dry powder dose for delivery into a user's lungs. The DPI devices feature replaceable dry powder cartridges (200). The DPI devices also feature a retractable configuration for storage and for accidental dispensing of dry powder. The DPI devices dispense dry powder in controlled dosages.

Provided herein are devices, systems, and methods for introducing a nebulized medication into breathing gas for respiratory therapy. An apparatus includes a reservoir to contain a volume of medication, a vibrating mesh disposed at a reservoir outlet of the reservoir to receive a flow of the medication from the reservoir and output a flow of nebulized medication, a mixing chamber having a gas inlet to receive a flow of breathing gas from a gas source, and a nebulizer inlet to receive the flow of nebulized medication from the vibrating mesh, where the vibrating mesh is disposed between the nebulizer inlet and the reservoir outlet. The apparatus can include a pressure tap tube or other implement in fluid communication with the mixing chamber and the reservoir to selectively equalize pressure between the mixing chamber and a headspace in the reservoir above the volume of medication.

An aerosol generator (1) with an active liquid container (4) and a nebulization chamber (2) associated therewith, which is connected to an inlet channel (10) for the supply of carrier gas and to an outlet channel (12) for the discharge of carrier gas mixed with aerosol obtained from the active liquid, is intended to enable a particularly good adjustability of the droplet size of the aerosols contained in the discharged carrier gas and thus a use particularly in the context of a transnasal inhalation therapy. For this purpose, the nebulization chamber (2) has a substantially rotationally symmetrical boundary wall (8), the inlet channel (10) being positioned and oriented in the region of its point of entry into the nebulization chamber (2) in such a way that its longitudinal axis is offset relative to the axis of symmetry of the nebulization chamber (2) in the region of the point of entry and does not intersect the axis of symmetry.