An iontophoresis system includes a preloaded reservoir containing one or more doses of a therapeutic agent. As a result, the therapeutic agent does not have to be loaded into the reservoir prior to use. In such a system, the preloaded reservoir is generally disposable. Various components of the iontophoresis system can be combined with the reservoir in a disposable cartridge that is selectively connectable to other, reusable components of the iontophoresis system. In addition, the entire iontophoresis system can be formed from one or more disposable, one-time-use modules.

Lung tumors are treated in-vitro and in-vivo by an apparatus and method for operating the apparatus wherein the lung being treated is made receptive to ultrasound in order to allow the ultrasound waves to be guided through the healthy lung tissue to the tumor tissue in an optimized manner for the use of FUS therapy.

The present invention relates to a method for assessing a patient's sensitivity to fluid removal from the patient's vascular system or to fluid replacement or addition with regard to the patient's hydration state, the method comprising the step of determining a value reflecting the distribution of fluid between at least two distribution spaces of the body of the patient or changes thereof from measured or calculated values, and assessing whether the value fulfills at least one criterion. It also relates to a controller, an apparatus, a device, a digital storage device, a computer program product, and a computer program.

An ultrasound catheter with fluid delivery lumens, fluid evacuation lumens and a light source is used for the treatment of intracerebral hemorrhages. After the catheter is inserted into a blood clot in the brain, a lytic drug can be delivered to the blood clot via the fluid delivery lumens while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the fluid evacuation lumens.

Provided herein are systems and methods for molecule delivery into cells. The method may include steps of forming a solution comprising an amount of microbubbles, an amount of soluble molecules, and one or more cells, flowing the solution through a microfluidic device, and sonicating the solution for a period of time sufficient to form pores in the one or more cells. In particular, such methods may be used for preservation of cells through delivery of a preservation agent.

A system for controlled neuromodulation procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Systems and methods for imaging, monitoring, stimulating, and/or ablating neurological structures coupled to one or more organs of the lower urinary tract (LUT) are disclosed. Such processes may be used to alter the hormonal secretions from one or more organs, to modulate the growth of an organ, alter the growth rate or rate of perineural invasion of a tumor, or the like. In particular such processes may be used to slow, halt and/or reverse the growth of a prostate gland or a prostate tumor.

Disclosed is an implantable medical device configured to detect opioid overdose symptoms, such as a critically low respiratory rate, and automatically release opioid overdose medication into the body of a user. The embedded device may use a ultrasound- or photoplethysmographic-based technique for monitoring the respiratory rate of the user. Additionally, the embedded medical device can communicate with a paired mobile device and automatically contact medical services and/or emergency contacts when opioid overdose is detected.

Device for shave-free trans-cranial focused ultrasound (FUS) treatment and method for using same, the device including a scalp cover having a first inlet configured to allow supply of a gas into the scalp cover, and an outlet configured to allow outflow of ambient air contained within the scalp cover when the gas is being supplied, such that the ambient air contained within the scalp cover is replaced by the supplied gas.

Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device including a therapeutic assembly having a PVDF transducer. A method for tissue denervation through the application of ultrasonic energy, can include positioning a PVDF transducer within a blood vessel of a patient; applying RF energy to the PVDF transducer thereby causing the PVDF transducer to deliver ultrasonic energy to the tissue; and at least partially denervating tissue that is innervated by neural matter located within or in proximity to the blood vessel via the ultrasonic energy delivered to the tissue.

Device for shave-free trans-cranial focused ultrasound (FUS) treatment and method for using same, the device including a scalp cover having a first inlet configured to allow supply of a gas into the scalp cover, and an outlet configured to allow outflow of ambient air contained within the scalp cover when the gas is being supplied, such that the ambient air contained within the scalp cover is replaced by the supplied gas.