Transdermal electrical stimulation (TES) applicators that are wearable and configured to attached to a subject's pinna (ear) and adapted to apply TES to modulate the subject's cognitive and/or physiological state. These apparatuses may be configured so that they can be worn against the ear (e.g., the cymba of the ear) to deliver TES. Also described herein are methods of using them to modulate a subject's cognitive state. These TES applicators may also be adapted to function as audio headphones for concurrent delivery of TES and audible signals (e.g., music).

Systems and methods for enhancing wellness in a habitable space are provided. In some forms, an example system for enhancing wellness in a habitable space includes a control system having a processor, communication circuitry, and a memory. The communication circuitry of the control system is configured to communicate with one or more devices positioned within the habitable space. One or more sensors may also be positioned proximate the habitable space to detect indicia (e.g., biometric characteristics of a user, behavioral characteristics of a user, and environmental characteristics) and communicate the detected indicia to the control system. Based at least in part on the detected indicia, the control system is configured to trigger initiation of a scene in the habitable space by communicating a signal to at least one of the devices in the habitable space to adjust operation thereof.

A method of treating a human subject which is effected by inhalation of gaseous nitric oxide, the method comprising a first treatment period comprising administering gNO by inhalation over a period of about at least 5 days, wherein the first treatment period is followed by a second treatment period comprising administering gNO by inhalation over a period of at least 3 months. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract.

The disclosed embodiments are directed to methods for determining, based on input from a manual insulin delivery device, for example, an insulin pen, a proper bolus dosing to be delivered by an AID system, to assess the sufficiency of the user-administered basal dose of long-acting insulin and to recommend any changes to the long-acting delivery following a daily analysis of the user's blood glucose readings.

This invention relates to an ingestible drug delivery device configured for wireless communication with other ingestible drug delivery devices.

A method and apparatus for determining gastric content volume. The internal temperature of the contents of the stomach is measured at least one predetermined time t after the patient is fed, and the gastric volume determined from the temperature. In preferred embodiments, a known volume of water at a known temperature is injected into the stomach, and the temperature of the stomach contents is measured after the stomach temperature has stabilized. An apparatus for performing the method, in which continuous measurement is possible without disturbing the patient's feeding schedule, and a method for using the inventive method in the control of an automatic feeding apparatus, are also disclosed.

Disclosed are various examples and embodiments of a cardiac mapping catheter configured for electrophysiological (EP) mapping and suitable for intravascular insertion in a patient's heart, and methods of making same. The cardiac mapping catheter comprises a plurality support arms having electrodes disposed thereon. Various configurations of the cardiac mapping catheter are described and disclosed which provide improved spatial resolution and sensing of EP signals acquired from inside a patient's heart.

Devices, systems, and methods for detecting a sealing condition between a patient interface and a patient, and adjusting the patient interface to maintain the patient interface in sealing contact with the patient. The patient interface may include a sealing structure to form a seal on the patient, and a positioning structure to secure the sealing structure to the patient. The patient interface may include a sensor coupled to the sealing structure. A processor determines the sealing condition between the sealing structure and the patient based on a signal from the sensor, and adjusts at least one of the sealing structure and the positioning structure to maintain the sealing structure in sealing contact with the patient. A prediction system predicts a leak between the sealing structure and the patient based on the sensor signal. A learning system learns how to fit the sealing structure to the patient to form a seal.

A drug delivery system for delivering a drug product is provided that includes a drug product container containing a drug product, a fluid path adapted to receive the drug product from the drug product container, and a drug delivery device positioned along and/or adjacent to the fluid path. The drug delivery device may include a housing, a fluid displacement assembly at least partially supported by and/or surrounded by the housing, and a drive component at least partially supported by and/or surrounded by the housing. The drive component may drive the medicament through the fluid displacement assembly. Further, the drug delivery device includes a controller workingly coupled with the drive component for controlling the drug delivery device. The controller may operate in a normal operation mode and a reserve mode.

An ear-worn electronic device includes a right ear device comprising a first processor and a left ear device comprising a second processor communicatively coupled to the first processor. A physiologic sensor module comprises one or more physiologic sensors configured to sense at least one physiologic parameter from a wearer. A motion sensor module comprises one or more sensors configured to sense movement of the wearer. The first and second processors are coupled to the physiologic and motion sensor modules. The first and second processors are configured to produce a three-dimensional virtual sound environment comprising relaxing sounds, generate verbal instructions within the three-dimensional virtual sound environment that guide the wearer through a predetermined mental exercise that promotes wearer relaxation, and generate verbal commentary that assesses wearer compliance with the predetermined mental exercise in response to one or both of the sensed movement and the at least one physiologic parameter.