A medical device that includes a shaft defining a lumen and a distal portion, the distal portion defining a side opening in fluid communication with the lumen. The medical device includes a device coupled to the distal portion of the shaft and overlying the side opening. The device includes an expandable member configured to expand laterally outward from a collapsed state to an expanded state, and configured to permit fluid to flow through the expandable member and into the side opening. The device includes a constricting device positioned in contact with the expandable member and configured to move relative to the expandable member from a first position to a second position. The expandable member is in the collapsed state when the constricting device is in the first position and the expandable member is in the expanded state when the constricting device is in the second position.

A medical system includes a porous body positioned at a target site within a subject, a tube including a wall defining a tube lumen, where the tube is connected to the porous body at a first end of the tube, and a sealing device to seal the target site from a body lumen. When the sealing device seals the target site from the body lumen, the tube extends from the target site into the body lumen.

A medical system including a porous body connected to a distal end of a vacuum tube, and a patch defining a lumen therethrough for accommodating the vacuum tube, where the patch is fluidly seals the porous body from a body lumen when the patch is deployed in a subject.

A medical system including a tube defining a lumen, a porous body connected to a distal end of the tube to be advanced to a target site within a subject. The porous body defines a plurality of openings, the plurality of openings are in fluid connection with the lumen, the porous body includes a first material and a second material, and the second material elutes from the porous body in the subject.

Various embodiments of the present disclosure include a consumable capsule containing an active ingredient in at least one compartment movably sealed by a stimuli responsive actuator, and an activation device configured to communicate with the consumable capsule. The activation device is configured to emit a wireless signal to activate the stimuli responsive actuator of the consumable capsule, and the consumable capsule is configured to deliver the active ingredient into an external environment based on the activation of the stimuli responsive actuator. In an example, the active ingredient is released into the external environment, whereas in another example, the active ingredient is injected into the external environment.

In a method of collecting a tissue in a bile duct, the method includes a step A of inflating a balloon in the bile duct and pressing the balloon against a wall of the bile duct, a step B of, in a state where a guide tube is positioned by using the balloon, bending a distal end portion of the guide tube so that a distal end opening of the guide tube is directed toward the wall of the bile duct, a step C of inserting a treatment tool into the guide catheter and protruding a distal end portion of the treatment tool toward the wall, and a step D of collecting a tissue using the treatment tool.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

A medical system includes a propellant source containing a propellant fluid, containers containing a material, and a shaft having a plurality of lumens, each of the plurality of lumens having a first opening at a proximal end of the shaft and a second opening at a distal end of the shaft. The plurality of lumens are fluidly coupled to one or more of the propellant source and at least one of the plurality of containers, and a first lumen surrounds, is coaxial with, or is side-by-side with, at least one other lumen.

A device may be configured to deliver an agent to a target tissue via pressurized fluid and the device may include a catheter including a lumen; an enclosure configured to store an agent, receive a pressurized fluid, and release a combination of the pressurized fluid and the agent; and a valve downstream of the enclosure to receive the combination of the pressurized fluid and the agent from the enclosure. The valve may have a first configuration preventing flow of the combination through the lumen and a second configuration permitting flow of the combination through the lumen.

Method for introducing and maintaining a level of negative pressure in a body cavity of at least 80 mmHg using a tube having an elongate distal portion and a proximal portion having first and second arms, each arm having a lumen in flow communication with one another and with the body cavity via apertures at or near the distal end of the tube, wherein the first arm or tubular extension therefrom is adaptable to receive suction from a suction source. An indicator, arranged in relation to the second arm, signals when a specific negative pressure has been exceeded in the tube, or a valve, arranged in relation to the second arm, admits ambient air into the lumen of the second arm when suction is applied to the tube and differential air pressure between the air in the lumens of the tube and ambient air exceeds a specified amount.