The disclosure provides systems and methods for adjusting a multi-leaf collimator (MLC). The MLC includes a plurality of cross-layer leaf pairs, each cross-layer leaf pair of the plurality of cross-layer leaf pairs includes a first leaf located in a first layer of leaves and a second leaf opposingly located in a second layer of leaves. For at least one cross-layer leaf pair, an effective cross-layer leaf gap to be formed between the first leaf and the second leaf may be determined; at least one of the first leaf or the second leaf may be caused to move to form the effective cross-layer leaf gap; and an in-layer leaf gap may be caused, based on the effective cross-layer leaf gap, to be formed between the first leaf and an opposing first leaf in the first layer. A size of the in-layer leaf gap may be no less than a threshold.

Systems and methods for radiation treatment planning can include a computing system determining an estimate of radiation dose distribution within an anatomical region of a patient, and determining a cost matrix representing an objective function, using the estimate of radiation dose distribution. The computing system can project the cost matrix on each of a plurality of fluence planes. Each of the plurality of fluence planes can be associated with a corresponding gantry-couch orientation of a plurality of gantry-couch orientations of a medical linear accelerator. The computing system can determine, using projections of the cost matrix on each of the plurality of fluence planes, a sequence of gantry-couch orientations among the plurality of gantry-couch orientations representing a treatment path.

A method for generating a minibeam, including focusing the incident beam through a first quadrupole along a first direction and through a second quadrupole along a second direction orthogonal to the first direction, deflecting the incident beam, through a third magnet along a third direction and through a fourth magnet according to a distinct fourth direction, adjusting a magnetic field gradient generated by first quadrupole and/or respectively by the second quadrupole so that a focal length of the first quadrupole is superior or equal to 60 and/or is less than or equal to 250 cm and/or respectively a focal length of the second quadrupole is superior or equal to 50 and/or is less than or equal to 200 cm for the focused beam to meet the criteria of a minibeam along a volume extending between a focal point of the first quadrupole and a focal point of the second quadrupole.

A system and method for injecting an electron beam to an accelerator are provided. The system may include a cathode, an anode, and a modulation electrode. The cathode, for generating the electron beam, may have a first electrical potential. The anode may have a second electrical potential. The modulation electrode, located between the cathode and the anode, may be configured to adjust at least one parameter of the electron beam. The at least one parameter of the electron beam may include at least one transverse parameter of the electron beam.

A device and a process for performing high temporal- and spatial-resolution MR imaging of the anatomy of a patient during intensity modulated radiation therapy (IMRT) to directly measure and control the highly conformal ionizing radiation dose delivered to the patient for the treatment of diseases caused by proliferative tissue disorders. This invention combines the technologies of open MRI, multileaf-collimator or compensating filter-based IMRT delivery, and cobalt teletherapy into a single co-registered and gantry mounted system.

A computer implemented system and method for providing general data protection regulation (GDPR) compliant hashing in blockchain ledgers. The invention guarantees a user's right to be forgotten, in compliance with the GDPR regulations, utilizing blockchain technologies.

A leaf unit assembly for a multi-leaf collimator comprises a leaf, a leaf actuator screw having a first end fixedly attached to the leaf, and a rotatable part threadably engaged with the leaf actuator screw.

A mount for an array of leaf drive units corresponding to a single leaf bank of a multi-leaf collimator comprises a plurality of separable mounting plates. Each mounting plate comprises an array of mounting holes, and each mounting hole is arranged to receive a respective one of the leaf drive units.

A computer-implemented method of performing a radiation therapy process includes: while a patient is disposed in a first position and maintains a first inspiration level, acquiring a set of projection images of a target volume associated with the patient; based on a treatment planning digital volume associated with the radiation therapy process and the set of projection images, generating a synthetic digital volume that includes the target volume; based on a treatment plan associated with the treatment planning digital volume and on the synthetic digital volume, generating a modified treatment fraction; and while the patient remains in the first position and maintains at least the first inspiration level, performing the modified treatment fraction.

A sterilizable device comprising electromagnetic transponders separated from one another by a flexible spacer material enclosed within radiofrequency-transparent sterilizable tubing for target tracking during prostate treatments, and method of use thereof.