Senescent cells are implicated in aspects of age-related decline in health and may contribute to certain diseases. Senescent cells also limit the viability of cells in cell culture. The invention includes methods of using a stressor (e.g., shock waves, pneumatics, hydraulics, magnetic elements, etc.) to reverse senescence. In embodiments, cells are exposed to ultrasound to reverse senescence. Ultrasound can be used to administered in short duration pressure waves to cells to create mechanical stresses. These conditions are safe for normal tissue and do not adversely influence their function. The stressor can rejuvenate senescent cells so that they are phenotypically normal. Additional embodiments include methods of treating senescence-associated diseases and disorders by administering a stressor such as low frequency ultrasound (LFU). The methods described herein can also be used for slowing the aging process and/or reducing signs of aging.

Catheter-based devices and associated methods for immune system neuromodulation of human patients are disclosed herein. One aspect of the present technology is directed to methods of treating a human patient diagnosed with an immune system condition. The methods can include intravascularly positioning a neuromodulation catheter within a blood vessel proximate to neural fibers innervating an immune system organ of the patient. The method also includes reducing sympathetic neural activity in the patient by delivering energy to the neural fibers innervating the immune system organ via the neuromodulation catheter. Reducing sympathetic neural activity improves a measurable physiological parameter corresponding to the immune system condition of the patient.

A method of treating a patient having inflammation or an infection from bacteria or molds or fungi or virus by destroying bacteria or molds or fungi or virus has the step of directing one or more sound wave treatments into the patient to destroy bacteria or molds or fungi or virus. The sound wave treatments cause an improved blood supply, a disruption of cellular membranes and a cellular communication causing the patient's cells to identify and attack the bacteria, mold fungi or virus and further causes recruiting or stimulating an increase in anti-microbial peptides. The method further can have the step of administering medications to the patient including, but not limited to anti-viral medications, antibiotics, anti-fungal medications or anti-mold medications, wherein the sound wave treatment extends the useful life of the medications.

A pain relief, fracture healing and spinal fusion device that comprises of a carrier that defines a centrally placed ultrasound transducer receiving hub and a left and a right electrode sheet, an ultrasound transducer that attaches to the receiving hub, and a controlled electrical generating device that connects to the carrier. The controlled electrical generating device powers and controls the frequency of the ultrasound transducer and the current delivered to the electrode sheets.

An ultrasonic therapy apparatus includes a plurality of ultrasonic transducers, a processor that identifies a position of an affected part and determines a focal point of ultrasonic waves radiated by the plurality of ultrasonic transducers based on the determined position of the affected part, and a drive circuit that generates a drive signal for driving the plurality of ultrasonic transducers at individual timings so that the ultrasonic waves are focused at the determined focal point.

A neurosurgical ultrasonic focusing assisted three-stage atomization cooling and postoperative wound film forming device has a transducer housing and a nozzle, wherein a horn is arranged in the transducer housing, at least two layers of piezoelectric ceramic sheets are arranged at the top of the horn, an electrode sheet connected with an ultrasonic generator is arranged between two adjacent layers of piezoelectric ceramic sheets, the bottom of the transducer housing is of a hemispherical structure, and a plurality of piezoelectric elements connected with the ultrasonic generator are arranged inside the hemispherical structure; and the nozzle is arranged at the bottom of the horn and connected with a medical nanofluid storage cup, compressed gas can also be introduced into the nozzle, and an electrode is also arranged inside the nozzle.

One embodiment is directed to a non-contact, medical ultrasound therapy system for generating and controlling low frequency ultrasound. The ultrasound therapy system includes a treatment wand including an ultrasonic transducer, a generator unit, and a cable coupling the treatment wand to the generator unit. The generator unit generates electric power output to drive the ultrasonic transducer and includes a digital frequency generator, wherein the generator unit digitally controls energy output at resonance frequency of the ultrasonic transducer.

Human and animal biofilms and pathogens are treated with extracorporeal acoustic pressure shock waves at a location of prosthesis or implant in a body.

An ultrasonic medical treatment probe has a head with a distal-most circular rim extending along an endless uninterrupted perimeter around a broad recess and formed with a series of serrations or teeth. The rim is thin in comparison to the width of the recess. The serrations or teeth preferably extend continuously along an entire circumference or length of the rim. The probe head is provided along the rim with a plurality of notches or openings communicating with the recess.

Ultrasound (US) apparatus and method for applying low energy US onto an internal tissue/organ, including a non-invasive US appliance used on a treatment region over the internal tissue/organ, and an electrical stimulation apparatus for simultaneously inducing interferential electrical stimulation. A controller controls parameters of the electrical stimulation apparatus and the US appliance, and dynamically changes at least one of the parameters, for maintaining the impedance of the body tissue in the treatment region within an impedance range. The US apparatus includes an impedance monitoring apparatus for continuously measuring, tracking, and monitoring impedance in the treatment region, wherein the controller dynamically changes at least one of the parameter in response to the impedance as monitored, for maintaining the impedance within the predefined range. The internal tissue/organ can be a female fertility organ, which can be, an ovarian follicle, a blood vessel of the uterus (womb), the ovary, the endometrial lining, and the Fallopian tube, ulcer, closed wound, internal injury, inflammation. and nerves.