A neuromodulation device, system, and method comprising a patch having an energy generator that is removably positionable proximate to a sexual organ of a patient or user in order to alter the user's sexual climax or orgasm. The device stimulates nerve proximate to the sexual organ to either intensify or delay a timing of a sexual climax or orgasm.

Methods, devices and systems are described for decreasing the activity of the sympathetic nervous innervation to and from the lungs and the vessels supplying the lungs to treat pulmonary medical conditions such as asthma. In one embodiment, the method may involve advancing an intravascular instrument to a target location in a blood vessel within the intercostal vasculature to ablate either or both the sympathetic afferent and efferent nerves lying within the paravertebral gutter including the visceral fibers that travel to the cardiothoracic cavity and abdominopelvic viscera and the T1 to T4/5 sympathetic chain. In another embodiment, an intravascular instrument may be advanced to the bronchial vessels to ablate either or both the sympathetic afferent and efferent nerves in and around the posterior pulmonary plexus. In one embodiment the ablative agent is a neurolytic agent delivered in a gel. This approach may be utilized to treat other cardiac and pulmonary diseases.

An implantable ultrasound generating treating device (12) to induce spinal cord or spinal nerves treatment, suitable for implantation in the spinal canal and comprises an elongate support member (22, 32) and an array of several treatment transducers (20) distributed along the elongate support member. The several treatment transducers (20) comprise radial transducers emitting an ultrasound treatment beam oriented radially, wherein the treatment transducers (20) have a resonant frequency comprised between 0.5 and 4 MHz. The device has articulating portions so that the implantable device can adapt its shape to a curved elongation path. Also disclosed is an apparatus including the implantable ultrasound generating treating device and methods comprising inserting the implantable ultrasound generating treating device (12) inside the spinal canal of the spine of the patient.

Ultrasound (US) apparatus and method for applying low energy US onto an internal tissue/organ, including a non-invasive US appliance used on a treatment region over the internal tissue/organ, and an electrical stimulation apparatus for simultaneously inducing interferential electrical stimulation. A controller controls parameters of the electrical stimulation apparatus and the US appliance, and dynamically changes at least one of the parameters, for maintaining the impedance of the body tissue in the treatment region within an impedance range. The US apparatus includes an impedance monitoring apparatus for continuously measuring, tracking, and monitoring impedance in the treatment region, wherein the controller dynamically changes at least one of the parameter in response to the impedance as monitored, for maintaining the impedance within the predefined range. The internal tissue/organ can be a female fertility organ, which can be, an ovarian follicle, a blood vessel of the uterus (womb), the ovary, the endometrial lining, and the Fallopian tube, ulcer, closed wound, internal injury, inflammation. and nerves.

The present disclosure provides a system for functional ultrasound imaging, where the system comprises: a) an apparatus for delivering a nucleic acid encoding a mechanosensitive ion channel to a target neural cell population in a region of a brain; and b) a functional ultrasound imaging device. The present disclosure provides a method for functional ultrasound imaging.

A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.

A neuromodulation such as ultrasound therapy having a cuff and transducer to removably position on a penis of a patient in order to treat premature ejaculation. The transducer stimulates a dorsal nerve of the penis in order to stimulate or inhibit the nerve pathway between the penis and the brain in order to delay ejaculation until the user or their partner desires to have an ejaculation occur.

Provided herein are methods, systems, and related vectors and compositions allowing for noninvasive control of neural circuits. In particular, the methods and systems herein described utilize acoustically targeted chemogenetics to achieve a noninvasive neuromodulation in specifically selected cell-types among spatially selected brain regions.

The present disclosure relates to a method for converting magnetic resonance imaging (MRI) to a computed tomography (CT) image using an artificial intelligence machine learning model, for use in ultrasound treatment device applications. The method includes acquiring training data including an MRI image and a CT image for machine learning; training an artificial neural network model using the training data, wherein artificial neural network model generates a CT image corresponding to the MRI image, and compares the generated CT image with the original CT image included in the training data; receiving an input MRI image to be converted to a CT image; splitting the input MRI image into a plurality of patches; generating patches of a CT image corresponding to the patches of the input MRI image using the trained artificial neural network model; and merging the patches of the CT image to generate an output CT image.

A method for destroying cells and/or microorganisms in an organism includes the following steps: (a) administering to the organism a composition including a sonosensitizing compound containing at least one transition metal with three bidentate ligands; and (b) exposing the sonosensitizing compound in the organism to ultrasound, wherein the ultrasound is effective to activate the sonosensitizing compound to destroy at least one of the cells and the microorganisms in the organism. The ultrasound is preferably used in conjunction with electromagnetic therapies comprising photodynamic therapy, low-level laser therapy, and radiation therapy. The ultrasound is preferably administered at a duty cycle in the range from 5% to 95% at a power density of 10 W/cm.sup.2 and a frequency in the range from 10 Hz to 10 MHz.