The present invention relates to HER2 (Human Epidermal Growth Factor Receptor 2) antibodies to prevent or treat cancers. The antibodies of the invention binds specifically to HER2 over-expressed in cancer cells (particularly, breast cancer and stomach cancer cells), specifically to an epitope on HER2 being different from epitope for trastuzumab. The CDR sequences of the present antibodies exhibit low similarity to CDR sequences of publicly known HER2 antibodies, addressing that the CDR sequences are unique. The antibodies of the present invention in combination with trastuzumab kill cancer cells with significantly enhanced cytotoxicity and therefore very effective in therapy of cancer (particularly, breast cancer and stomach cancer). Without wishing to be bound by theory, the enhanced efficacies of the combined therapy would address that the antibodies of the present invention bind to epitope on HER2 being different from epitope for trastuzumab, and inhibit HER2 in a cooperative manner with trastuzumab.

Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.

Disclosed is the use of a cell-free fat extract for preparing a composition or a preparation. The composition or the preparation is used for preventing and/or treating ovarian insufficiency and/or complications thereof. The cell-free fat extract has an excellent therapeutic effect on ovarian insufficiency and/or complications thereof.

Disclosed is the use of a cell-free fat extract for preparing a composition or a preparation. The composition or the preparation is used for preventing and/or treating ovarian insufficiency and/or complications thereof. The cell-free fat extract has an excellent therapeutic effect on ovarian insufficiency and/or complications thereof.

A pharmaceutical composition and a food composition for preventing, alleviating or treating precocious puberty, which contain, as an active ingredient, a hot-water extract of Coicis Semen and Artemisia capillaris, which inhibits early ovary growth and the production of follicle-stimulating hormone. The composition contains a hot-water extract of Coicis Semen and Artemisia capillaris, which can inhibit early ovary growth and follicle stimulating hormone production, thereby preventing, alleviating or treating precocious puberty.

A pharmaceutical composition and a food composition for preventing, alleviating or treating precocious puberty, which contain, as an active ingredient, a hot-water extract of Coicis Semen and Artemisia capillaris, which inhibits early ovary growth and the production of follicle-stimulating hormone. The composition contains a hot-water extract of Coicis Semen and Artemisia capillaris, which can inhibit early ovary growth and follicle stimulating hormone production, thereby preventing, alleviating or treating precocious puberty.

Methods and compositions are provided for treatment of disorders associated with aberrant adrenal cortex cell behavior, including (but not limited to) treatment of adrenocortical carcinoma (ACC), Cushing's syndrome and/or pituitary ACTH excess (Cushing's Disease). Such methods involve administration of an effective amount N-(2,6-bis(1-methylethyl)phenyl)-N-((1-(4-(dimethylamino)phenyl)cyclopentyl)-methyl)urea hydrochloride to the patient.

We disclose growth hormone fusion proteins that have increased in vivo stability and activity; nucleic acid molecules encoding said proteins and methods of treatment of growth hormone related diseases that would benefit from growth hormone agonists or antagonists.

The present invention provides 3-[2-fluoro-5-(2,3-difluoro-6-methoxybenzyl-oxy)-4-methoxyphenyl]-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,4-d]pyrimidine-5-carboxylic acid choline salt having excellent solubility and storage stability.

The present invention provides 3-[2-fluoro-5-(2,3-difluoro-6-methoxybenzyl-oxy)-4-methoxyphenyl]-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,4-d]pyrimidine-5-carboxylic acid choline salt having excellent solubility and storage stability.