Provided herein are recombinant cardiomyocytes and cardiomyocyte cell lines expressing human Ether-a-go-go Related Gene (hERG) potassium ion channel, including, for example, stable cell lines, that comprise a transfected or transduced nucleic acid sequence encoding hERG. Also provided herein are methods of using the recombinant cardiomyocytes and cardiomyocyte cell lines expressing hERG for screening compounds for cardiotoxicity, including methods for determining the activity of compounds to inhibit hERG.

A biochip for the integration of all steps in a complex process from the insertion of a sample to the generation of a result, performed without operator intervention includes microfluidic and macrofluidic features that are acted on by instrument subsystems in a series of scripted processing steps. Methods for fabricating these complex biochips of high feature density by injection molding are also provided.

A biochip for the integration of all steps in a complex process from the insertion of a sample to the generation of a result, performed without operator intervention includes microfluidic and macrofluidic features that are acted on by instrument subsystems in a series of scripted processing steps. Methods for fabricating these complex biochips of high feature density by injection molding are also provided.

Sensors having an advantageous design and methods for fabricating such sensors are generally provided. Some sensors described herein comprise pairs of electrodes having radial symmetry, pairs of nested electrodes, and/or nanowires. Some embodiments relate to fabricating electrodes by methods in which nanowires are deposited from a fluid contacted with a substrate in a manner such that it evaporates and is replenished.

Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for identifying a protein in a sample of unknown proteins, comprising receiving information of a plurality of empirical measurements performed on the unknown proteins; comparing the information of empirical measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein among a plurality of candidate proteins; and for each of one or more of the plurality of candidate proteins, generating a probability that the candidate protein generates the information of empirical measurements, a probability that the plurality of empirical measurements is not observed given that the candidate protein is present in the sample, or a probability that the candidate protein is present in the sample; based on the comparison of the information of empirical measurements against the database.

The present invention relates to a method and a device for the chemical-free determination of the chemical oxygen demand (CODs) in aqueous samples. The object of the invention, to develop a method that compensates for the disadvantages of the standard method and at the same time is at least as good as this, in that it can determine the COD quickly and with a high measurement frequency without chemicals and is cheap and has a low personnel requirement and should be simple to automate, is achieved in that the chemical oxygen demand of aqueous samples is determined by non-specific oxidation of water components at an electrode (11), assisted by (ultra)sound from a sound source (15) in a frequency range in which no significant quantities of oxidative species are formed, i.e. below the cavitation threshold.

Disclosed are devices, systems and methods for direct measurement of polymerase activity. In one example, a device includes at least a first electrode and a second electrode, the first and second electrode being separated by a gap; and a polymerase with two attachment sites, one for attaching to the first electrode and a second for attaching to the second electrode, wherein the two attachment sites are separated by a distance of at least about 1 nm and the distance does not significantly change with conformational changes of the polymerase.

Provided is a technology of accurately classifying abnormality in response characteristics of an air-fuel ratio sensors into six deterioration modes. In order to solve the above problems, the present disclosure provides a control device including a microprocessor that detects a response delay of an air-fuel ratio sensor attached to an internal combustion engine, in which the microprocessor includes a target air-fuel ratio change unit configured to change a target air-fuel ratio between lean and rich, and a response delay detection unit configured to detect a respond delay of the air-fuel ratio sensor that occurs in a real air-fuel ratio sensor signal output from the air-fuel ratio sensor when the target air-fuel ratio is changed between the lean and the rich by the target air-fuel ratio change unit.

The invention provides a novel method of coating the inside of a capillary with a polymeric material. The method can include introducing a catalyst-free solution of a monomer and initiator, wherein the monomer is present in about 1-10% (w/v) and the initiator is present in 0.1-1% (w/v), into a capillary and thermally initiating polymerization of the monomer thereby providing a capillary comprising an internal polymeric coating for separating, identifying, and quantifying components of an analyte.

An O.sub.2 sensor has a sensor element, which includes a solid electrolyte layer and a pair of electrodes, while the solid electrolyte layer is interposed between the electrodes. The O.sub.2 sensor outputs an electromotive force signal in response to an air-to-fuel ratio of exhaust gas of an engine, which serves as a sensing subject. A constant current circuit, which induces a flow of a predetermined constant electric current between the pair of electrodes of a sensor element, and a current sensing arrangement, which senses a current value of an actual electric current that is conducted through the sensor element, are provided. A microcomputer determines whether an abnormality of the constant current circuit is present based on the current value of the electric current, which is sensed with the current sensing arrangement, in a case where the constant current is induced by the constant current circuit.