Microfluidic method and device that can be used for sensing and measurement of properties of liquids, gases, solutions, and particles is proposed, wherein the measurable liquid or gas (with or without particles) flow in at least one channel through a measurement chamber (cell) formed between at least two isolated electrodes is used for electrical impedance measurement. The proposed solution is characterized in that the cross-section of at least one pair of similar spatial electrodes decreases smoothly towards the tiny measurement chamber (cell) in order to increase the sensitivity and accuracy of the measurement. Typically, a device with multiple similar channels is advantageous to use for comparative measurement and differential measurement schemes.

A new method is described for the detection and classification of non-periodic signals and the respective system that implements it, within the scope of flow cytometry techniques for the acquisition of biological information in order to increase the accuracy in the detection of labeling particles.

This is achieved through the use of classifiers of the composed or independent type (20), which apply to an input signal (1) machine learning techniques, such as ANN (Artificial Neural Networks) (2), to execute a new detection methodology that combines the filtering and decision steps, as a way to classify non-periodic signals at the output of the classifier (3).

Disclosed is a method for simultaneous determination of particle size distribution, concentrations of nanoparticulate mercury (Hg-NPs) in natural soils. The method uses sodium pyrophosphate as the extractant, and allows quick extraction of Hg-NPs in the soil without dissolution or aggregation. In combination with spICP-MS determination, the method makes it possible to simultaneously determine the particle size distribution and concentration of Hg-NPs in the complex soil matrix, with accurate determination results.

A blood analyzer according to one or more embodiments may include: a specimen preparation part that prepares a measurement specimen by mixing a reagent into a blood preparation; a measurement part that measures the measurement specimen; a measurement mode selection unit that receives an input of a type of blood preparation as a measurement target selected from a plurality of types of blood preparations; and a controller. The controller may cause the specimen preparation part to prepare the measurement specimen depending on the selected type of blood preparation.

Method and system for determining a confinement size in a porous media, including subjecting the media to a substantially uniform static magnetic field, applying a magnetic resonance pulse sequence to the media, detecting magnetic resonance signals from the media, determining non-ground eigenvalues from the magnetic resonance relaxation spectrum, and determining a confinement size of the media from the eigenvalues.

There is provided a microfluidic device for single cell processing including: a substrate; a fluidic channel provided in the substrate; and a plurality of electrodes arranged adjacent to the fluidic channel for determining a position of a cell in the fluidic channel, the plurality of electrodes comprising a pair of sensing electrodes comprising a first sensing electrode and a second sensing electrode, wherein at least the first sensing electrode of the pair of sensing electrodes extends in a first direction, the pair of sensing electrodes is configured to measure a differential electrical signal across a sensing region as the cell flows through the sensor portion of the fluidic channel; and a biasing electrode arranged between the first sensing electrode and the second sensing electrode, the biasing electrode being configured to receive a biasing voltage. One of the second sensing electrode and the biasing electrode extends in a direction at least substantially parallel to the first sensing electrode and the other one of the second sensing electrode and the biasing electrode is arranged to have a slanted orientation with respect to the first sensing electrode. There is also provided a method of forming the microfluidic device, and a method and a system for single cell processing using the microfluidic device.

A microfluidic component used for measuring electrical impedance across a biological object, the component including a microfluidic space including a zone referred to as measurement zone, at least two electrodes arranged facing one another on each side of the measurement zone, the component being formed by assembling, along a longitudinal junction plane, at least two superposed layers referred to as lower layer and upper layer, the two layers each having at least one cavity, the two layers being assembled with one another in such a way as to position the two cavities facing one another in order to form the microfluidic space.

A dynamic impedance imaging system includes a dynamic impedance imaging sensor, an impedance detection and flow rate measurement module and an electrical impedance tomography (EIT) instrument. The impedance detection and flow rate measurement module is configured to detect an abnormal particle flowing through the dynamic impedance imaging sensor to obtain a flow rate of the abnormal particle, and generate a synchronous trigger signal. The EIT instrument is configured to inject a sinusoidal excitation current into the dynamic impedance imaging sensor under the trigger of the synchronous trigger signal, perform multi-channel interleaved sampled for the abnormal particle according to the flow rate to acquire multi-channel sampled data, and calibrate the multi-channel sampled data to implement impedance tomography imaging for the abnormal particle.

A sheath flow impedance particle analyzer includes a pre-mixing cell, a sample needle, a sheath flow impedance counting cell, a front sheath fluid cell, a rear sheath fluid cell, a rear sheath waste fluid cell, a waste fluid cell, and a first auxiliary negative pressure source. The first auxiliary negative pressure source includes at least one low pressure port, and a valve for controlling the low pressure port to open or close, the low pressure port being connected to the sample needle or the rear sheath waste fluid cell. During measurement of a sample by the sheath flow impedance counting cell, at least the negative pressure of the first auxiliary negative pressure source enables the sample needle to transfer a sample liquid or enable the rear sheath waste fluid cell to discharge a waste fluid.

A particle analysis device includes multiple stacked plates joined together; an upper liquid space adapted to store a first liquid; a lower liquid space adapted to store a second liquid; a connection pore connecting the upper liquid space to the lower liquid space; a first hole extending from the top surface to the upper liquid space, the first liquid flowing through the first hole; and a second hole extending from the top surface to the lower liquid space, the second liquid flowing through the second hole. A first electrode and a second electrode that are sheets are pinched between two of the plates. The first electrode applies an electric potential to the first liquid in the upper liquid space through the first hole, whereas the second electrode applies an electric potential to the second liquid in the lower liquid space through the second hole. The particle analysis device further includes a first electrode-rod-insertion hole extending from the top surface to the first electrode, and a second electrode-rod-insertion hole extending from the top surface to the second electrode. The first electrode and the second electrode are not exposed at any side surface of the particle analysis device.