An electrochemical substrate holder assembly, including: a first housing and a second housing; wherein the first housing and the second housing collectively define an interior space; a first gasket coupled to the first housing and adapted to contact a first side of a substrate; and a second gasket coupled to the second housing and adapted to contact a second side of the substrate; wherein the first gasket and the second gasket are collectively adapted to hold the substrate within the interior space. The first housing defines a first port adapted to receive a first electrical lead to electrically contact the first side of the substrate. The second housing defines a second port adapted to allow a fluid to pass there through to fluidly contact at least the second side of the substrate. The second housing is adapted to receive one or more of a second and third electrical lead.

An electrochemical substrate holder assembly, including: a first housing and a second housing; wherein the first housing and the second housing collectively define an interior space; a first gasket coupled to the first housing and adapted to contact a first side of a substrate; and a second gasket coupled to the second housing and adapted to contact a second side of the substrate; wherein the first gasket and the second gasket are collectively adapted to hold the substrate within the interior space. The first housing defines a first port adapted to receive a first electrical lead to electrically contact the first side of the substrate. The second housing defines a second port adapted to allow a fluid to pass there through to fluidly contact at least the second side of the substrate. The second housing is adapted to receive one or more of a second and third electrical lead.

A sensor performs measurement of a culture medium and is used in a state of being immersed in a medium placed in a well, the sensor comprising a main body having a first surface and a second surface that is on the opposite side from the first surface; an electrode unit that is provided on the first surface in the main body and to which a specific voltage is applied in the course of performing measurement in a state of being immersed in the medium; and a liquid holding portion that is provided around the electrode unit on the first surface, and that is disposed near the inner wall surface of the well and holds the medium up to above the electrode unit, in between the inner wall surfaces.

A sensor performs measurement of a culture medium and is used in a state of being immersed in a medium placed in a well, the sensor comprising a main body having a first surface and a second surface that is on the opposite side from the first surface; an electrode unit that is provided on the first surface in the main body and to which a specific voltage is applied in the course of performing measurement in a state of being immersed in the medium; and a liquid holding portion that is provided around the electrode unit on the first surface, and that is disposed near the inner wall surface of the well and holds the medium up to above the electrode unit, in between the inner wall surfaces.

A method of measuring signals from a surface. The method comprises: placing on the surface a flexible sensing device having an array of coated electrodes, wherein at least one electrode of the array is metallic and is at least partially coated by a polymer; and collecting signals from the sensing device.

Various cell analysis systems of the present teachings can measure the electrical and metabolic activity of single, living cells with subcellular addressability and simultaneous data acquisition for between about 10 cells to about 500,000 cells in a single analysis. Various sensor array devices of the present teachings can have sensor arrays with between 20 million to 660 million ChemFET sensors built into a massively paralleled array and can provide for simultaneous measurement of cells with data acquisition rates in the kilohertz (kHz) range. As various ChemFET sensor arrays of the present teachings can detect chemical analytes as well detect changes in cell membrane potential, various cell analysis systems of the present teachings also provide for the controlled chemical and electrical interrogation of cells.

A self-vibrating pH probe comprise a housing containing an electronic assembly to which is coupled a vibration source element so that at least a portion of vibrations caused by the vibration source element propagate to the electronic assembly, the vibration source element being controllable for at least on/off operation. The self-vibrating pH probe further comprising a pH probe member having a probe tip at a first end, the probe member extending from the housing and mechanically and electrically coupled by a second end to the electronic assembly so that at least a portion of vibrations propagating to the electronic assembly further propagate to the probe tip; and further including a processor coupled to the electronic assembly for coordinating operation of the vibration source element and operation of the pH probe member.

An electrochemical measurement cartridge includes a container including a first analysis chamber for receiving a fluid to be analyzed and a second calibration chamber for receiving a calibration fluid; an electrochemical measurement sensor including at least one work electrode and one reference electrode; a container supporting the sensor and a cover arranged mobile relative to one another to confer on the cartridge at least two separate operating configurations, a first configuration in which the sensor is communicating with the first analysis chamber and a second configuration in which the sensor is communicating with the second calibration chamber; sealing between the chambers of the container and the cover; and a drive member for providing a relative movement of the container relative to the cover.

A probe for measuring a sample solution includes an outer body configured to receive an operational amount of a reference solution, and a sensor assembly including an inner body at least a portion of which is located inside the outer body. A shield is positioned between the outer surface of the inner body and the inner surface of the outer body. The shield is configured to be in contact with the reference solution and extends above the top surface of the reference solution when the probe is filled with an operational amount of the reference solution.

A probe chamber that includes a holder having a bore capable of holding a sensor or probe; a chamber housing having a central bore in fluid communication with the bore of the holder, wherein the chamber housing can be joined with the holder; and a measurement chamber in fluid communication with the central bore, wherein the measurement chamber comprises a gate, an inlet and an outlet and is capable of receiving a probe tip or sensor tip. Methods for calibrating a probe or sensor are also disclosed.