Provided is an electrochemical measurement device capable of measuring more accurately and an electrochemical measurement apparatus provided with the electrochemical measurement device. The electrochemical measurement device includes a base part, and a placement part on which an object to be measured is placed, the placement part being provided to the base part. The electrochemical measurement device also includes an electrode part provided near the placement part on the base part, a wiring part provided on a surface of the base part and electrically connected to the electrode part, and an insulator that covers the wiring part. Further, a protruding part is provided on the base part of the electrochemical measurement device so as to protrude past the insulator.

An electrochemical cell comprises a chamber, an inlet port, an outlet port, an electrode port, and a counter electrode. The inlet port is configured to allow flow of a liquid into the chamber and through an inlet opening toward the working electrode, and the outlet port is configured to allow flow of a liquid out of the chamber and through an outlet opening. The device is configured so that a force applied to the working electrode slides the first end face of the working electrode to a distance from a face of the inlet opening due to the balancing force of a fluid flowing out of the inlet opening. The device may be used in a method for analyzing an analyte, such as one or more amino acids in a liquid sample.

A sensor may include a sensing element retained within a storage compartment filled with a storage medium, which may also be used as a calibration medium. The sensing element can include a sensing surface located away from the distal end of the sensing element, such that an inactive section of the sensing element can cooperate with a sealing member such as an O-ring to form part of the seal retaining the storage/calibration medium. The sensing element can be extended and retracted from the storage compartment to expose the sensing surface to a process medium, while preserving the storage medium within the storage compartment for post-measurement validation.

A method for diagnosing acute coronary syndrome (ACS) in a subject, the method comprising measuring plasma macrophage migration inhibitory factor (MIF) concentration in a sample from the subject, and diagnosing ACS when the subject plasma MIF concentration is greater than a reference plasma MIF concentration, wherein the sample is taken less than 4 hours after symptom onset. The invention also relates to a method for prognosing ACS in a subject, the method comprising measuring plasma MIF concentration in a sample from the subject, diagnosing ACS when the subject plasma MIF concentration is greater than a reference plasma MIF concentration, and prognosing the magnitude of ACS from the subject plasma MIF concentration. Also provided is a method of treating ACS in a subject, a device, a kit, and a cardiac biomarker related to the methods of diagnosing and prognosing ACS.

A method for diagnosing acute coronary syndrome (ACS) in a subject, the method comprising measuring plasma macrophage migration inhibitory factor (MIF) concentration in a sample from the subject, and diagnosing ACS when the subject plasma MIF concentration is greater than a reference plasma MIF concentration, wherein the sample is taken less than 4 hours after symptom onset. The invention also relates to a method for prognosing ACS in a subject, the method comprising measuring plasma MIF concentration in a sample from the subject, diagnosing ACS when the subject plasma MIF concentration is greater than a reference plasma MIF concentration, and prognosing the magnitude of ACS from the subject plasma MIF concentration. Also provided is a method of treating ACS in a subject, a device, a kit, and a cardiac biomarker related to the methods of diagnosing and prognosing ACS.

A protective device is disclosed for electrochemical electrodes having a liquid junction, and a transport and retention system therefor. The protective device can include a casing which is configured as a hollow cylinder and which has a inner circumferential first protrusion; a delimiting device which together with the first protrusion delimits a first casing segment having a first inner diameter; a spacer, which is configured as a hollow cylinder having an outer diameter corresponding to the first inner diameter; and a first sealing ring and a second sealing ring between which the spacer is disposed; wherein the first sealing ring, the second sealing ring and the spacer are disposed in an interior of the first casing segment, so that the first sealing ring and the second seal ring delimit a first protection space for a liquid junction whose inner diameter corresponds to an inner diameter of the spacer.

The invention refers to a device and a method of quantification of analytes concentration, making use of a device that comprises an electrochemical cell (1) which contains the analyte, a load (2) which is connected in parallel to the electrochemical cell (1), and a readout unit (3), which is connected in parallel with the load (2). This includes the stages of quantification of the concentration of analytes, the charge transfer from the electrochemical cell (1) to the load (2), the determination of the voltage across the load (2) and the determination of the analyte concentration from the correlation between the analyte concentration and the voltage across the load (2).

The present disclosure relates to an inline sensor arrangement for the detection of measurement values of a measurand representing an analyte content of a measuring medium, which arrangement comprises: a sensor which is designed to generate and output a measurement signal correlated with the measurand, wherein the sensor has at least one sterile sensor element provided for contact with the measurement medium; and a housing surrounding the at least one sensor element, which housing encloses the sensor element in a chamber sealed tightly against an environment of the housing, and wherein the chamber contains inside it a gas volume that is designed such that an influence of harmful substances—in particular, of reactive nitrogen and/or oxygen species—on the at least one sensor element is largely prevented. The present disclosure further relates to a method for the production of said inline sensor arrangement, and for its commissioning.

An embodiment a pressure compensated pH sensor apparatus, including: a pH sensing component comprising a sensing portion that is exposed to a fluid source when in use; a pressure chamber located in a position under the sensing portion and that surrounds all of the sensing portion not exposed to the fluid source when in use; and a pressure compensation mechanism located within the pressure chamber, wherein the pressure compensation mechanism reacts to pressure from an environment outside the apparatus, thereby support the sensing portion.

An embodiment a pressure compensated pH sensor apparatus, including: a pH sensing component comprising a sensing portion that is exposed to a fluid source when in use; a pressure chamber located in a position under the sensing portion and that surrounds all of the sensing portion not exposed to the fluid source when in use; and a pressure compensation mechanism located within the pressure chamber, wherein the pressure compensation mechanism reacts to pressure from an environment outside the apparatus, thereby support the sensing portion.