Embodiments relate to a monolithic arrangement comprising one or more electrochemically responsive electrodes that are configured to generate a signal relating to a characteristic of a fluid sample; and one or more electronic circuits for processing signals generated by the at least one electrode. Optionally, the monolithic arrangement comprises a plurality of electrodes configured to implement potentiostat and/or galvanostat measurement techniques. Optionally, at least two of the plurality of electrodes have different electrochemical material layers to obtain correspondingly different electrode functionalization.

Embodiments relate to a monolithic arrangement comprising one or more electrochemically responsive electrodes that are configured to generate a signal relating to a characteristic of a fluid sample; and one or more electronic circuits for processing signals generated by the at least one electrode. Optionally, the monolithic arrangement comprises a plurality of electrodes configured to implement potentiostat and/or galvanostat measurement techniques. Optionally, at least two of the plurality of electrodes have different electrochemical material layers to obtain correspondingly different electrode functionalization.

A test device for testing an oxidation potential of an electrolyte is provided. The test device comprises a cavity, a test unit, a detector, a processing unit, and a display. The test unit comprises a positive plate comprising a first through hole, a negative plate comprising a second through hole, a first infrared window covering the first through hole, a second infrared window covering the second through hole, and an electrolyte located between the positive electrode plate and the negative electrode plate. The first through hole and the second through hole penetrate each other. The first infrared window, the positive plate, the negative plate, and the second infrared window are stacked with each other. An infrared light beam passes through the first infrared window, the first through hole, the electrolyte, the second through hole, and the second infrared window in sequence and then is detected by the detector.

An electrochemical substrate holder assembly, including: a first housing and a second housing; wherein the first housing and the second housing collectively define an interior space; a first gasket coupled to the first housing and adapted to contact a first side of a substrate; and a second gasket coupled to the second housing and adapted to contact a second side of the substrate; wherein the first gasket and the second gasket are collectively adapted to hold the substrate within the interior space. The first housing defines a first port adapted to receive a first electrical lead to electrically contact the first side of the substrate. The second housing defines a second port adapted to allow a fluid to pass there through to fluidly contact at least the second side of the substrate. The second housing is adapted to receive one or more of a second and third electrical lead.

An electrochemical substrate holder assembly, including: a first housing and a second housing; wherein the first housing and the second housing collectively define an interior space; a first gasket coupled to the first housing and adapted to contact a first side of a substrate; and a second gasket coupled to the second housing and adapted to contact a second side of the substrate; wherein the first gasket and the second gasket are collectively adapted to hold the substrate within the interior space. The first housing defines a first port adapted to receive a first electrical lead to electrically contact the first side of the substrate. The second housing defines a second port adapted to allow a fluid to pass there through to fluidly contact at least the second side of the substrate. The second housing is adapted to receive one or more of a second and third electrical lead.

Provided is an electrolyte analysis apparatus capable of diluting and preparing a reagent with higher accuracy with a simpler device configuration, comprising a first flow path configured to send a high-concentration reagent from a high-concentration reagent bottle, a second flow path configured to send a reagent diluent from a reagent diluent bottle that stores the reagent diluent for diluting the high-concentration reagent, a junction unit configured to join the first flow path and the second flow path, a third flow path configured to send a mixed liquid, a dilution tank configured to store the prepared reagent, a prepared reagent discharge nozzle configured to discharge the prepared reagent, a liquid sending mechanism configured to send the reagent and the reagent diluent to the junction unit at a predetermined ratio so that the prepared reagent has a predetermined concentration, and an analysis unit configured to perform analysis with the prepared reagent.

Provided is an electrolyte analysis apparatus capable of diluting and preparing a reagent with higher accuracy with a simpler device configuration, comprising a first flow path configured to send a high-concentration reagent from a high-concentration reagent bottle, a second flow path configured to send a reagent diluent from a reagent diluent bottle that stores the reagent diluent for diluting the high-concentration reagent, a junction unit configured to join the first flow path and the second flow path, a third flow path configured to send a mixed liquid, a dilution tank configured to store the prepared reagent, a prepared reagent discharge nozzle configured to discharge the prepared reagent, a liquid sending mechanism configured to send the reagent and the reagent diluent to the junction unit at a predetermined ratio so that the prepared reagent has a predetermined concentration, and an analysis unit configured to perform analysis with the prepared reagent.

Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.

Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.

Flexible fuel cell sensors and methods of making and using the same are provided. A fuel cell sensor can be used for the detection of, for example, isopropyl alcohol (IPA), and the working mechanism of the fuel cell sensor can rely on redox reactions. The fuel cell sensor can include a proton exchange membrane (PEM), an anode disposed on a first surface of the PEM, a cathode disposed on a second surface of the PEM opposite from the first surface, and a reference electrode disposed on the first surface of the PEM and spaced apart from the anode.