A gas sensor includes a detection circuit unit that detects a specific gas component in measured gas based on output from a sensor element. The detection circuit unit includes an AC voltage application unit that applies an AC voltage signal to a pair of electrode units in an electrochemical cell, a gas concentration detection unit that detects concentration information on the specific gas component from a DC signal component included in an output signal provided by the electrochemical cell, and a cell temperature detection unit that detects temperature information on the electrochemical cell from an AC signal component included in the output signal. The cell temperature detection unit includes a signal extraction unit that removes the DC signal component to separate the AC signal component from the output signal, and a synchronous detection unit that performs synchronous detection on the separated AC signal component using the AC voltage signal.

To provide a potential measurement device capable of keeping a temperature of a cell and/or a culture solution (in particular, a temperature of a cell) constant. Provided is a potential measurement device including a semiconductor substrate; a wiring layer on the semiconductor substrate; a first electrode on the wiring layer; and a second electrode configured to detect an action potential of a cell on the wiring layer. A temperature measurement unit is formed on the semiconductor substrate. A heat conduction unit and a plurality of wirings connected to the second electrode are formed in the wiring layer.

To provide a potential measurement device capable of keeping a temperature of a cell and/or a culture solution (in particular, a temperature of a cell) constant. Provided is a potential measurement device including a semiconductor substrate; a wiring layer on the semiconductor substrate; a first electrode on the wiring layer; and a second electrode configured to detect an action potential of a cell on the wiring layer. A temperature measurement unit is formed on the semiconductor substrate. A heat conduction unit and a plurality of wirings connected to the second electrode are formed in the wiring layer.

To accurately detect the moving state of secondary atomic ions at the time of targeted voltage application and the moving state of secondary atomic ions due to diffusion. An ion movement measuring device includes a test specimen and a detector. The test specimen has a first electrode, a second electrode, and an electrolyte disposed between them. The first electrode and the second electrode each have a layer of an identical element, and have the identical potential in a state where no voltage is applied from outside the test specimen. At least the first electrode contains second atoms being isotopes of first atoms at an abundance ratio higher than a natural abundance ratio of the second atoms, the first atoms being present at a highest natural abundance ratio in the element. The detector detects some of ions of the first atoms and the second atoms, which are discharged from the electrolyte.

For sensing pH of a fluid, a heating apparatus of a semiconductor die controls a temperature of the fluid to a first temperature. A first voltage of a gate of a floating gate transistor of the semiconductor die is measured while the temperature of the fluid is at the first temperature. Also, the heating apparatus controls the temperature of the fluid to a second temperature that is different than the first temperature. A second voltage of the gate is measured while the temperature of the fluid is at the second temperature. The pH of the fluid is determined based on the first and second voltages, the first temperature and the second temperature.

Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.

A self-vibrating pH probe comprise a housing containing an electronic assembly to which is coupled a vibration source element so that at least a portion of vibrations caused by the vibration source element propagate to the electronic assembly, the vibration source element being controllable for at least on/off operation. The self-vibrating pH probe further comprising a pH probe member having a probe tip at a first end, the probe member extending from the housing and mechanically and electrically coupled by a second end to the electronic assembly so that at least a portion of vibrations propagating to the electronic assembly further propagate to the probe tip; and further including a processor coupled to the electronic assembly for coordinating operation of the vibration source element and operation of the pH probe member.

This disclosure relates to improved devices, systems and methods for detecting and measuring oxidizing compounds in test fluids. Certain embodiments include a measurement device configured to apply a constant current to the test fluid and measure a reference voltage indicating an electrochemical potential at which electrolysis occurs in the test fluid. The measurement device is further configured to measure a second voltage indicating an oxidizing potential of the test fluid, and to calculate an oxidizer concentration measurement indicating the concentration of the oxidizing compound in the test fluid based on a voltage difference between the reference voltage and the second voltage.

An apparatus is provided for sensing a molecule in a sample. The apparatus utilizes an electric field to draw molecules from a first chamber through an aperture, defined by a chemical layer, into a second chamber. The apparatus can detect a DNA molecule with, for example, 4, 5, or 6 unique base pairs. As molecules pass through the aperture, a sensor detects or measures a change in an electric parameter used to generate the electric field, thereafter translating the change in the electric parameter into information about the molecule. A divider element separates the first and second chambers and supports a chemical layer defining the aperture. The apparatus enables detection or measurement of molecules over prolonged time at a higher electric field strength than other nanopores, due to a combination of the shape of the divider, structural elements thereon, and thickness of the chemical layer at the aperture.

A device, liquid handling cartridge and related method for detecting the presence or absence of a chemical or biological target within a sample. The method includes the steps of: providing an electrochemical cell with a first electrode module and a second electrode; providing an electronic component between the first electrode module and the second electrode; introducing the sample into the electrochemical cell; measuring the potential difference between the first electrode module and second electrode; and confirming the presence of the chemical or biological target if the measured potential difference exceeds a predetermined threshold value.