A microscope for microscopic examination of a sample includes: a microscope housing enclosing an illumination optics, a microscope stage, and an imaging optics; an integrated sample chamber located within the microscope housing; and an integrated reagent chamber located within the microscope housing, the integrated reagent chamber supplying a reagent to the sample.

Systems, devices and methods for cell analysis provide an end user with real-time cell analysis and imaging of single cells in a population. Various cell analysis systems can provide both optical imaging, as well as electroscopic imaging, which is an image of cellular response as detected by sensors covering a cell footprint or cellular efflux. An automated fluidic system can provide an end-user selected sequence of reagents to cells, while precision controlled sensor array device thermostatting, and analysis compartment environmental control provide consistency in the cell analysis system environment.

Ethoxy-nonafluorobutane (C.sub.4F.sub.9OC.sub.2H.sub.5) is used as an immersion medium for immersing an immersion objective of a cryo-light microscope. The cryo-light microscope comprising an immersion objective, a front lens mount holding a front lens of the immersion objective, a sample holder and a cold stage carrying the sample holder further has a heating device coupling a heat flow into the front lens mount.

A module for a microscope stand comprises a control device with at least one computer hardware component being configured to control the microscope stand. The module further comprises a locating device configured to interact with another locating device formed in a housing of the microscope stand for mounting the module at a predetermined installation site within the housing.

An apparatus and method for simultaneous imaging and execution of contact-free directed hydrodynamic flow in a specimen. The apparatus includes a laser adapted to dynamically heat the specimen, a microscope with an objective adapted to image at least a part of the specimen and to guide a light beam of the laser into and/or onto the specimen to heat at least one specified location of the specimen, means for manipulating the specified location, and a sample chamber for the specimen that is accessible for imaging radiation and the light beam to allow simultaneous imaging and manipulation of the sample via the objective.

An apparatus and method for simultaneous imaging and execution of contact-free directed hydrodynamic flow in a specimen. The apparatus includes a laser adapted to dynamically heat the specimen, a microscope with an objective adapted to image at least a part of the specimen and to guide a light beam of the laser into and/or onto the specimen to heat at least one specified location of the specimen, means for manipulating the specified location, and a sample chamber for the specimen that is accessible for imaging radiation and the light beam to allow simultaneous imaging and manipulation of the sample via the objective.

An incubator and shelf with integrated microscope and wireless transmitter comprises a shelf adapted for use inside an incubator; a microscope integrated into the shelf; and a wireless (such as Wi-Fi) transmitter that wirelessly transmits an image produced by the microscope. Embodiments may be powered by the incubator, and may have an inverted microscope that views an object from below.

An incubator and shelf with integrated microscope and wireless transmitter comprises a shelf adapted for use inside an incubator; a microscope integrated into the shelf; and a wireless (such as Wi-Fi) transmitter that wirelessly transmits an image produced by the microscope. Embodiments may be powered by the incubator, and may have an inverted microscope that views an object from below.

A system for microscopic examination of a sample has a microscope and an incubation environment conditioning unit connected to the microscope. The microscope has a microscope housing enclosing an illumination optics, a microscope stage and an imaging optics, an integrated sample chamber located within the microscope housing and formed by a separated housing section within the microscope housing. The housing section has a microscope interface for connecting the incubation environment conditioning unit to the sample chamber and/or to a stage top chamber for placing within the sample chamber and for receiving the sample. The system provides a first and a second incubation modes. In the first incubation mode the sample chamber is incubated by supply of a first incubation atmosphere by the incubation environment conditioning unit. In the second incubation mode the stage top chamber is incubated by supply of a second incubation atmosphere by the incubation environment conditioning unit.

The invention relates to a microscope for microscopic examination of a sample comprising a microscope housing enclosing an illumination optics, a microscope stage and an imaging optics, an integrated sample chamber located within the microscope housing and formed by a separated housing section within said microscope housing, the housing section comprising a lid providing direct access to the microscope stage for placing the sample in the sample chamber, wherein said housing section comprises an interface for connection of an external incubation environment conditioning unit to the sample chamber, the interface being configured to provide a connection between said external incubation environment conditioning unit and the sample chamber, such that the environmental conditions in the sample chamber can be controlled when the external incubation environment conditioning unit is connected to the interface.