A membrane-type sensor, which has a membrane allowing a specific substance in a sample solution to permeate through the membrane and detects the specific substance that has permeated through the membrane based on a current flowing between working and counter electrodes immersed in an internal solution, and which is of an internal solution replenishment type configured to allow the internal solution to be supplied from an outside, includes a housing that contains the internal solution and an electrode structure having a tip end surface on which the working electrode is exposed, and a lid member that is attached to a tip end portion of the housing and fixes the membrane in a sandwiching manner along with the housing such that the membrane opposes the tip end surface of the electrode structure. The lid member has an opposing surface opposing the tip end surface of the electrode structure.

A membrane-type sensor, which has a membrane allowing a specific substance in a sample solution to permeate through the membrane and detects the specific substance that has permeated through the membrane based on a current flowing between working and counter electrodes immersed in an internal solution, and which is of an internal solution replenishment type configured to allow the internal solution to be supplied from an outside, includes a housing that contains the internal solution and an electrode structure having a tip end surface on which the working electrode is exposed, and a lid member that is attached to a tip end portion of the housing and fixes the membrane in a sandwiching manner along with the housing such that the membrane opposes the tip end surface of the electrode structure. The lid member has an opposing surface opposing the tip end surface of the electrode structure.

Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

A reference electrode system for a pH-sensor system includes: a first junction having a membrane with a sealed side; a reference electrode, the reference electrode and/or an electrically conducting wire of the reference electrode being covered completely except for an end portion of the reference electrode, by a sleeve; and a tube that is arranged, at least partly, around the reference electrode, the electrically conducting wire, and the sleeve, the tube having a closed end which is arranged near the end portion of the reference electrode.

Embodiments provide a chemical sensor device that is a chemical sensor using a nucleic acid compound and a specific blocking agent and can detect a target substance with high sensitivity, and a method for detecting a target substance.

A chemical sensor device of an embodiment includes a sensitive film, a nucleic add compound that is immobilized on the sensitive film, and a phosphoric acid derivative that is immobilized on a surface of the sensitive film on which the nucleic add compound is immobilized.

Embodiments provide a chemical sensor device that is a chemical sensor using a nucleic acid compound and a specific blocking agent and can detect a target substance with high sensitivity, and a method for detecting a target substance.

A chemical sensor device of an embodiment includes a sensitive film, a nucleic add compound that is immobilized on the sensitive film, and a phosphoric acid derivative that is immobilized on a surface of the sensitive film on which the nucleic add compound is immobilized.

A single-use disposable potentiometric reference sensor includes an insulating base substrate, a reference electrode disposed on the insulating base substrate where the reference electrode is a silver-silver chloride electrode, an internal layer disposed on the reference electrode where the internal layer is an amorphous salt layer that includes an amorphous polysaccharide and a salt having equi-mobility cations and anions, and a semipermeable cover membrane disposed over the internal layer where the semipermeable cover membrane has water vapor and ion permeability.