A method of calibrating a nanofluidic device including a plurality of nanopore channels, a plurality of gating nanoelectrodes, and a plurality of sensing nanoelectrodes, includes applying a selecting voltage across a gating nanoelectrode of the plurality of gating nanoelectrodes to select a nanopore channel. The method also includes tuning the nanopore channel by applying a first biasing voltage across a sensing electrode of the plurality of sensing nanoelectrodes, and receiving a plurality of currents over a plurality of frequencies. The method further includes generating a calibration data set from the pluralities of frequencies and currents. Moreover, the method includes comparing the calibration data set with a reference data set. In addition, the method includes when the calibration data set differs from the reference data set by more than a predetermined threshold, repeating the method with a second biasing voltage different from the first biasing voltage.

The present invention relates to body fluid monitoring. It is proposed to incorporate a reagent-free calibration method into a patch or wearable. The method comprises capturing molecules of interest, i.e. calibration molecules inside the bioliquid of the patient, and release them when needed for calibration. This eliminates the need for onboard reagent storage. Because the calibration is done in the same bioliquid, any matrix effects are corrected for.

The present invention appropriately determines a time to replace a responsive glass membrane for measuring a sample containing hydrofluoric acid. A measurement device for measuring a hydrogen ion concentration of a liquid sample containing hydrofluoric acid, the measurement device including a glass electrode that measures a hydrogen ion concentration in the liquid sample, the glass electrode including a responsive glass membrane, a membrane resistance measurement unit that measures a membrane resistance value of the responsive glass membrane, a temperature measurement unit that measures a temperature of an environment in which the responsive glass membrane is disposed, and an output unit that outputs a replacement index for replacing the responsive glass membrane based on the membrane resistance value and the temperature.

A method and apparatus for compensates for oxygen sensor aging determines a correction of by measuring oxygen content above a specified threshold value and measuring current flowing through the sensor over time.

A method and apparatus for operating a multi-gas sensor are disclosed. In an embodiment, a method includes providing at least one calibration input comprising sensor design data of the multi-gas sensor, which varies dependent on production process parameters, and/or sensor production process parameter data of the multi-gas sensor, and/or measurement results of the multi-gas sensor captured when the multi-gas sensor is exposed to one of the gases or a gas mixture to be detected and/or sensed by the multi-gas sensor; providing a trained neural network including an input layer with K input nodes, an output layer with L output nodes and at least one hidden layer; storing each calibration input as a fixed input to a corresponding input node of the trained neural network; and providing a multi-gas sensor output for at least a part of the gases to be detected and/or sensed by the multi-gas sensor dependent on the trained neural network and actual measured sensor values from the sensor elements.

A method of calibrating a detector that includes a volatile organic compound (VOC) sensor is provided. The method includes assembling the detector with the VOC sensor for field deployment and calibrating the VOC sensor using carbon monoxide (CO) as a calibrant prior to the field deployment.

An online calibration system for an electrochemical sensor. The calibration system comprises a calibration electrode coupled with a redox species, where the redox species is configured to control a pH of a reference solution local to the calibration electrode, such that when a voltammetric signal is applied to the calibration electrode the output generated from the calibration system is determined by the local environment pH. The output signal from the calibration system is used to calibrate a reference potential generated by a reference system of the electrochemical sensor to correct for drift in the reference potential when the electrochemical sensor is being used. The calibration electrode may be disposed in a reference cell of the electrochemical sensor.

An electrochemical-sensing apparatus for analyzing a sample of a user. The apparatus has a housing with a port for receiving an electrochemical-sensor structure having a counter electrode (CE), a reference electrode (RE), and at least one working electrode (WE) for contacting the sample, and an analysis circuitry for coupling to the electrodes for analyzing biomarkers in the sample, and an output for outputting an analytical result. The analysis circuitry has a circuit for generating an excitation signal and applying it to CE and RE, at least one frequency analyzer for receiving a return signal from the at least one WE for analyzing the sample, and a set of switches for short-circuiting CE and RE and for engaging at least one calibration resistor to CE/RE and the at least one frequency analyzer for directing a calibration signal to the at least one frequency analyzer component for calibration.

The disclosed techniques include obtaining a first signal generated by an electrochemical glucose sensor and a second signal generated by an optical glucose sensor, and obtaining a glucose value indicative of a user's blood glucose level, where the glucose value and the second signal are obtained at different times. The disclosed techniques further cause calculating a mapped value for the second signal based on the first signal, and calibrating the mapped value of the second signal based on the glucose value.

The present invention provides a method for determining whether or not a capillary filled with an electrophoretic medium is suitably used for electrophoresis before electrophoresis is performed using the analytes. The method comprises (a) applying an alternating-current voltage between a first electrode which is in contact with a first electrolyte solution in which one end of the capillary is immersed and a second electrode which is in contact with a second electrolyte solution in which the other end of the capillary is immersed to measure an electric conductivity of the electrophoresis medium with which an inside of the capillary is filled; and (b) determining that the capillary filled with the electrophoresis medium fails to be used suitably for the electrophoresis, when the electric conductivity is more than 4.2 mS/cm.