Devices, assays and methods for detecting analytes in a sample are provided. Biosensor devices include a biosensor interface that includes enzyme-conjugated molecules, antibodies and an enzyme driven redox cycle coupled to an electrically conductive electrode for signal amplification. The biosensor devices are easily adaptable to a variety of assay formats, a variety of target analytes and provide real-time measurements combined with high sensitivity and high specificity for the analyte.

Devices, assays and methods for detecting analytes in a sample are provided. Biosensor devices include a biosensor interface that includes enzyme-conjugated molecules, antibodies and an enzyme driven redox cycle coupled to an electrically conductive electrode for signal amplification. The biosensor devices are easily adaptable to a variety of assay formats, a variety of target analytes and provide real-time measurements combined with high sensitivity and high specificity for the analyte.

The present invention relates to systems, methods, and devices for determining the concentration of an analyte in a sample. The use of linear, cyclic, or acyclic voltammetric scans and/or semi-integral, derivative, or semi-derivative data treatment may provide for increased accuracy when determining the concentration of an analyte in a sample. Hematocrit compensation in combination with the data treatments may reduce the hematocrit effect with regard to a glucose analysis in whole blood. In another aspect, fast scan rates may reduce the hematocrit effect.

The present invention relates to systems, methods, and devices for determining the concentration of an analyte in a sample. The use of linear, cyclic, or acyclic voltammetric scans and/or semi-integral, derivative, or semi-derivative data treatment may provide for increased accuracy when determining the concentration of an analyte in a sample. Hematocrit compensation in combination with the data treatments may reduce the hematocrit effect with regard to a glucose analysis in whole blood. In another aspect, fast scan rates may reduce the hematocrit effect.

The present invention relates to a microfluidic method for analyzing a fluid containing a metal trace element, in particular arsenic, comprising the following steps of introducing a fluid sample into at least one micro-channel of a microfluidic circuit; mixing, within the micro-channel of the microfluidic circuit, the introduced fluid sample with nitric acid and L-cysteine, and measuring the quantity of metal trace element present in the sample, using an electrochemical detection method.

The present invention relates to a microfluidic method for analyzing a fluid containing a metal trace element, in particular arsenic, comprising the following steps of introducing a fluid sample into at least one micro-channel of a microfluidic circuit; mixing, within the micro-channel of the microfluidic circuit, the introduced fluid sample with nitric acid and L-cysteine, and measuring the quantity of metal trace element present in the sample, using an electrochemical detection method.

A system for performing electrochemical and hydrogen permeation measurements using a test specimen subject to tensile stress comprises a first housing filled with a process fluid supplied via an inlet with hydrogen sulfide, a second housing filled with a basic solution, a test specimen positioned between the first and second housings exposed to the process fluid on one side and to the basic solution on the other, first and second potentiostats coupled to the first and second housings to measure corrosion and induce hydrogen permeation, a loading device adapted to apply a longitudinal strain on the specimen, and a computing device configured to control operation of the potentiostat and loading device. The hydrogen sulfide in the process fluid impedes formation of diatomic hydrogen from atomic hydrogen, allowing adsorbed atomic hydrogen to enter into the steel test specimen from one side and permeate into the other side of the test specimen.

A system for performing electrochemical and hydrogen permeation measurements using a test specimen subject to tensile stress comprises a first housing filled with a process fluid supplied via an inlet with hydrogen sulfide, a second housing filled with a basic solution, a test specimen positioned between the first and second housings exposed to the process fluid on one side and to the basic solution on the other, first and second potentiostats coupled to the first and second housings to measure corrosion and induce hydrogen permeation, a loading device adapted to apply a longitudinal strain on the specimen, and a computing device configured to control operation of the potentiostat and loading device. The hydrogen sulfide in the process fluid impedes formation of diatomic hydrogen from atomic hydrogen, allowing adsorbed atomic hydrogen to enter into the steel test specimen from one side and permeate into the other side of the test specimen.

Devices for detecting a particle in a fluid sample are provided. The device includes a segmented microfluidic conduit configured to carry a flow of a fluid sample, where the conduit includes one or more nodes and two or more sections, and a node is positioned between adjacent sections of the conduit. The device also includes a detector configured to detect a change in current through the conduit. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic assays.

Devices for detecting a particle in a fluid sample are provided. The device includes a segmented microfluidic conduit configured to carry a flow of a fluid sample, where the conduit includes one or more nodes and two or more sections, and a node is positioned between adjacent sections of the conduit. The device also includes a detector configured to detect a change in current through the conduit. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic assays.