A method for a system and method for morphometric detection of malignancy associated change (MAC) is disclosed including the acts of obtaining a sample; imaging cells to produce 3D cell images for each cell; measuring a plurality of different structural biosignatures for each cell from its 3D cell image to produce feature data; analyzing the feature data by first using cancer case status as ground truth to supervise development of a classifier to test the degree to which the features discriminate between cells from normal or cancer patients; using the analyzed feature data to develop classifiers including, a first classifier to discriminate normal squamous cells from normal and cancer patients, a second classifier to discriminate normal macrophages from normal and cancer patients, and a third classifier to discriminate normal bronchial columnar cells from normal and cancer patients.

An excrement management system according to an embodiment includes: a closet bowl in which a bowl part for receiving excrement is formed; a light emitting unit configured to emit light toward an inner part of the closet bowl; a light receiving unit comprising an image sensor configured to receive light; a cloud server and an edge server configured to analyze light reception data received by the light receiving unit; a first communication device configured to transmit the light reception data to the cloud server; and a second communication device configured to transmit the light reception data to the edge server. The cloud server analyzes the light reception data to determine a characteristic of excrement, and the edge server analyzes the light reception data to determine whether to transmit the light reception data to the cloud server by the first communication device.

Disclosed are systems and methods of label-free detecting cellular physiological activities involving monitoring local refractive index changes associated with cellular physiological activities using a single ultracompact light emitting diode (LED) chip serving as a refractometer.

This disclosure relates generally to the differentiation of human pluripotent stem cells, and more particularly to a method of spatially adsorbing morphogens to differentiate human pluripotent stem cells.

A method for achieving microfluidic perfusion of a spheroid, the method being implemented in a microfluidic device that includes a cavity for hydrodynamically trapping the spheroid, the method including performing a first injection of a gel containing the spheroid into the microfluidic network, hydrodynamically trapping the spheroid in the trapping cavity of the microfluidic network, performing a second injection of a fluid that is non-miscible with the gel into the microfluidic network with a view to flushing away gel present in the network, except in the trapping cavity, cross-linking the gel present around the spheroid, in the trapping cavity, performing a third injection of a culture medium into the microfluidic network with a view to perfusing the spheroid petrified in its gelled environment, and located in the trapping cavity.

The present invention provides methods for profiling the microbiome of a subject from a sample obtained from the subject using a Scent Reader/Recorder which detects and records the scent in the headspace of the sample and generates a pattern of sensor signals that can be analyzed using machine learning techniques. The invention further provides methods for detecting changes in the microbiome profile of a subject, and methods for providing health and nutritional recommendations to subjects.

A particle analysis method and apparatus, including a spectrometry-based analysis of a fluid sample (1), comprises the steps of creating a sample light beam S and a probe light beam P with a light source device (10) and periodically varying a relative phase between the sample and probe light beams S, P with a phase modulator device (20), irradiating the fluid sample (1) with the sample light beam S, detecting the sample and probe light beams S, P with a detector device (40), and providing a spectral response of the at least one particle (3), wherein the light source device (10) comprises at least one broadband source, which has an emission spectrum covering a mid-infrared MIR frequency range, and the phase modulator device (20) varies the relative phase with a scanning period equal to or below the irradiation period of irradiating the at least one particle (3, 4).

To optimize an imaging range in a depth direction in terms of a relationship with a resolution, an OCT apparatus includes a signal processor that determines a reflected light intensity distribution of an imaging object on the basis of a spectrum of a detected interference light. The signal processor performs spectrum conversion, having a conversion characteristic with which a light source spectrum is converted to a Gaussian distribution curve, on the spectrum of the interference light, and determines the reflected light intensity distribution by Fourier-transforming a spectrum resulting from the spectrum conversion. In the conversion characteristic, the light source spectrum and the Gaussian distribution curve have center wavelengths differing from each other.

The instant invention provides near-infrared fluorescent biological contrast agents and methods of using them.

Various non-invasive sensors are adapted to be placed on a surface of an object having a volume with an internal region. The internal region of the object has internal properties indicated by corresponding internal parameters and an internal temperature distribution that is a function of the internal parameters and surface thermal signals. Each non-invasive sensor includes a heat flux sensor having one or more heat flux sensor output terminals to provide a measured heat transfer signal for the surface of the object, and a temperature sensor having one or more temperature sensor output terminals to provide a measured temperature signal for the surface of the object. Systems including one or more of the sensors perform non-invasive sensing of the object including accurate and rapid determination of an internal temperature distribution of the internal region of the object as well as one or more other internal properties of the object.