Methods are described for measuring the amount of one or more of vitamin A, α-tocopherol, and the combination of β-tocopherol and γ-tocopherol in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying one or more of vitamin A, α-tocopherol, and the combination of β-tocopherol and γ-tocopherol in a sample.

The present disclosure is directed to methods reagents and kits for solid phase extraction, derivatization with crown ether containing derivatizing agents, and mass spectrometry of the derivatized analytes.

The present disclosure is directed to methods reagents and kits for solid phase extraction, derivatization with crown ether containing derivatizing agents, and mass spectrometry of the derivatized analytes.

The present invention relates to antibodies that bind to soluble BCMA (sBCMA). Moreover, the invention relates to a detection system comprising such antibodies. The antibodies or the detection system may be used for detecting or quantifying sBCMA, for diagnosing a disease associated with sBCMA, for patient stratification, monitoring disease progression, and evaluating the therapeutic response.

The present invention relates to antibodies that bind to soluble BCMA (sBCMA). Moreover, the invention relates to a detection system comprising such antibodies. The antibodies or the detection system may be used for detecting or quantifying sBCMA, for diagnosing a disease associated with sBCMA, for patient stratification, monitoring disease progression, and evaluating the therapeutic response.

The present invention relates to compositions and methods relating to biomarkers (e.g., calcitriol (i.e., 1,25(OH).sub.2D.sub.3) to 24,25-dihydroxyvitamin D.sub.3 (i.e., 24,25(OH).sub.2D.sub.3) to calcifediol (i.e., 25(OH)D.sub.3) proportion ratio (C24CPR)) that can be used for detection and treatment assessment of vitamin D deficiency or vitamin D imbalance and/or diseases or disorders associated with vitamin D deficiency or vitamin D imbalance, such as cancer, in a subject in need thereof. The present invention also provides methods of diagnosing vitamin D deficiency or vitamin D imbalance and/or diseases or disorders associated with vitamin D deficiency or vitamin D imbalance and distinguishing between different types of diseases or disorders associated with vitamin D deficiency or vitamin D imbalance (e.g., cancer vs autoimmune disease or disorder).

The present invention relates to compositions and methods relating to biomarkers (e.g., calcitriol (i.e., 1,25(OH).sub.2D.sub.3) to 24,25-dihydroxyvitamin D.sub.3 (i.e., 24,25(OH).sub.2D.sub.3) to calcifediol (i.e., 25(OH)D.sub.3) proportion ratio (C24CPR)) that can be used for detection and treatment assessment of vitamin D deficiency or vitamin D imbalance and/or diseases or disorders associated with vitamin D deficiency or vitamin D imbalance, such as cancer, in a subject in need thereof. The present invention also provides methods of diagnosing vitamin D deficiency or vitamin D imbalance and/or diseases or disorders associated with vitamin D deficiency or vitamin D imbalance and distinguishing between different types of diseases or disorders associated with vitamin D deficiency or vitamin D imbalance (e.g., cancer vs autoimmune disease or disorder).

A biosensor, including a modified gold electrode and a macrophage RAW264.7 immobilized on the modified gold electrode. The disclosure also provides a method of preparing the biosensor and a method of using the same for evaluation of antioxidant capacity of substances.

A method for providing nutritional supplement information for a subject is proposed, including a sequence of steps in given order and repeated at least once after a time span of at least 2 days or one week for adapting the provided nutritional information: A) taking a sample from the subject; B) analyzing said sample to determine the nutritional status; C) based on the results calculation of nutritional supplements to improve the nutritional status; D) providing individualized nutritional supplement information. This sequence involves the prediction of at least one initial characteristics matrix and multiplication of this matrix weighted with factors, with an initial recommendation vector for the calculation of a target profile vector after a given first time interval from the profile vector as determined in step B), and in each following cycle adaptation by adapting at least one of the characteristics matrix and the weighting factors.

A method for providing nutritional supplement information for a subject is proposed, including a sequence of steps in given order and repeated at least once after a time span of at least 2 days or one week for adapting the provided nutritional information: A) taking a sample from the subject; B) analyzing said sample to determine the nutritional status; C) based on the results calculation of nutritional supplements to improve the nutritional status; D) providing individualized nutritional supplement information. This sequence involves the prediction of at least one initial characteristics matrix and multiplication of this matrix weighted with factors, with an initial recommendation vector for the calculation of a target profile vector after a given first time interval from the profile vector as determined in step B), and in each following cycle adaptation by adapting at least one of the characteristics matrix and the weighting factors.