In certain aspects, the present invention provides methods for dosing a patient with an ActRIIb antagonist and methods for managing patients treated with an ActRIIb antagonist. In certain aspects, the methods involve measuring one or more hematologic parameters in a patient.

In certain aspects, the present invention provides methods for dosing a patient with an ActRIIb antagonist and methods for managing patients treated with an ActRIIb antagonist. In certain aspects, the methods involve measuring one or more hematologic parameters in a patient.

The present invention relates to the field of treating iron deficiency with IV iron carbohydrate complexes such ferric carboxymaltose, monitoring or identifying subjects to determine their eligibility for being administered said IV iron carbohydrate complexes, and combining said IV iron carbohydrate complexes with additional drugs in order to mitigate or reduce side effects induced by said IV iron carbohydrate complexes.

The present invention relates to the field of treating iron deficiency with IV iron carbohydrate complexes such ferric carboxymaltose, monitoring or identifying subjects to determine their eligibility for being administered said IV iron carbohydrate complexes, and combining said IV iron carbohydrate complexes with additional drugs in order to mitigate or reduce side effects induced by said IV iron carbohydrate complexes.

A method for determining or approximating a patient's daily loss of iron (fe_loss), the method comprising the steps of determining the patient's iron uptake (fe_uptake); determining the quantity of iron stored within the patient's body; and determining the patient's daily loss of iron based on the patient's iron uptake (fe_uptake) and the quantity of non-functional iron stored within the patient's body. The method relates further to apparatuses and an erythropoesis stimulating medicament for use in the treatment of anaemia. Finally the present invention relates to digital storage means, a computer program product, and a computer program.

A method for determining or approximating a patient's daily loss of iron (fe_loss), the method comprising the steps of determining the patient's iron uptake (fe_uptake); determining the quantity of iron stored within the patient's body; and determining the patient's daily loss of iron based on the patient's iron uptake (fe_uptake) and the quantity of non-functional iron stored within the patient's body. The method relates further to apparatuses and an erythropoesis stimulating medicament for use in the treatment of anaemia. Finally the present invention relates to digital storage means, a computer program product, and a computer program.

A blood analyzer comprises a light source unit configured to irradiate light on a measurement sample prepared from blood, a fluorescent light detecting unit configured to detect auto-fluorescence produced by red blood cells in the measurement sample which is irradiated by light, an information processing unit configured to obtain auto-fluorescence information related to red blood cells which produce auto-fluorescence detected by the fluorescent light detecting unit. The information processing unit is configured to make a determination regarding anemia based on the auto-fluorescence information.

A blood analyzer comprises a light source unit configured to irradiate light on a measurement sample prepared from blood, a fluorescent light detecting unit configured to detect auto-fluorescence produced by red blood cells in the measurement sample which is irradiated by light, an information processing unit configured to obtain auto-fluorescence information related to red blood cells which produce auto-fluorescence detected by the fluorescent light detecting unit. The information processing unit is configured to make a determination regarding anemia based on the auto-fluorescence information.

The present invention relates to an ex vivo analytic method for analysis of a sample (S1), comprising the steps: A) Determining Fe2.sup.+, Fe3.sup.+, Fe-Ferritin and total Fe content in sample (S1), comprising the steps: A1) Separating simultaneously Fe2.sup.+, Fe3.sup.+ and Fe-Ferritin present in a sample (S1); and A2) Quantifying simultaneously Fe2.sup.+, Fe3.sup.+, Fe-Ferritin separated in step A1) and total Fe based on sample (S1); B) Determining S and Se containing compounds content of sample (S1), comprising the steps B1) Separating simultaneously S and Se containing compounds present in sample (S1); and B2) Quantifying simultaneously S and Se containing compounds separated in step B1) of sample (S1). Further, the invention relates to a kit for performing the analytic method.

The present invention relates to an ex vivo analytic method for analysis of a sample (S1), comprising the steps: A) Determining Fe2.sup.+, Fe3.sup.+, Fe-Ferritin and total Fe content in sample (S1), comprising the steps: A1) Separating simultaneously Fe2.sup.+, Fe3.sup.+ and Fe-Ferritin present in a sample (S1); and A2) Quantifying simultaneously Fe2.sup.+, Fe3.sup.+, Fe-Ferritin separated in step A1) and total Fe based on sample (S1); B) Determining S and Se containing compounds content of sample (S1), comprising the steps B1) Separating simultaneously S and Se containing compounds present in sample (S1); and B2) Quantifying simultaneously S and Se containing compounds separated in step B1) of sample (S1). Further, the invention relates to a kit for performing the analytic method.