A sensing device comprising: a light detection and ranging (LiDAR) sensor; and one or more optical spectroscopic sensors configured to extract biomarker information from one or more optical measurements of a user.

In some embodiments, systems, methods, and media for capsule-based multimode endoscopy are provided. In some embodiments, a probe for capsule-based multimode endoscopy is provided, the probe comprising: a rigid capsule; a flexible tether coupled to a proximal end of the capsule; a rotatable reflective surface disposed within the capsule; a static ball lens disposed within the capsule; a first optical fiber optically coupled to the ball lens, the first optical fiber passing through the flexible tether; a second optical fiber optically coupled to the ball lens, the second optical fiber passing through the flexible tether; a graded index fiber disposed between a distal end of the second optical fiber and the ball lens, the graded index fiber optically coupled to the second optical fiber and the ball lens.

A method and a device for label-free all-optical neural regulation and imaging are provided. The method stimulates a neural activity through an infrared laser pulse, and acquires an optical scattered signal caused by the neural activity by optical coherence tomography (OCT) to realize label-free all-optical neural regulation and imaging. The method specifically includes: aiming an infrared laser at a target brain region, injecting a certain time series of laser pulses, synchronously scanning and imaging the target brain region by OCT, analyzing a relative change of an OCT scattered signal before and after laser stimulation, and acquiring a brain function signal based on OCT to realize synchronous neural regulation and imaging. The method and the device enable synchronous neural regulation and imaging without causing crosstalk between the regulation and imaging channels, and without the need for injection of a contrast agent or viral transfection.

A dilator used in performing a transseptal puncture; it has a hub with an opening at a proximal end; a shaft, connected to a distal end of the hub, comprising a lumen miming along a length of the shaft defining an inner wall within the shaft; an optical fiber for insertion into the lumen of the shaft, the optical fiber comprising a proximal end portion for sealing the opening of the hub, the optical fiber having a length for running along a length of the lumen; wherein the optical fiber is configured to, in a simultaneous or alternating fashion: propagate a laser beam with an ultrafast pulse duration that is generated by an ultrafast laser; and propagate light for obtaining visualization information from the light interacting with neighboring surfaces in the heart using optical coherence tomography.

A method for reproducing a lumen curve to a given tolerance in at least one image in optical coherence tomography (OCT). Examples of applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, cardio applications, and being obtained via one or more optical instruments, such as, but not limited to, catheters. The method may include obtaining a set of original points of the curve that correspond to measurements from an optical imaging device. Filtering the set of original points using at least one criteria to obtain a subset of original points. The method may also include determining if the subset of original points is less than a predetermined threshold and adjusting the at least one criteria to increase an amount of original points included in the subset of original points when it is determined that the subset of original points is less than the predetermined threshold.

A precision forward-looking image-guided diagnostic and therapeutic surgical probe and needle insert for microsurgery in support of imagery, neurology, neurosurgical procedures, and ophthalmic surgical applications comprising an introducer needle (stylet), a fiber carrier, a therapeutic conduit, and a spirographic method for scanning a target and associated algorithms to create and render a reconstructed image for display to a physician in real-time or near real-time. The probe implements Optical Coherence Tomography (OCT) to provide high-resolution extended imagery of an intended therapeutic or target tissue. A separate therapeutic conduit provides surgical access for therapeutic devices such as a cutting or ablation laser, an RF electrode for locally heating tissue, a lumen for local injection of neurolytics/paralytics, placement of electrodes for neuromodulation, and deployment of a micro-endoscopic imaging tool. A third working channel supports the delivery of neurolytic and other fluids.

Systems, methods, and devices for directed to duplex imaging techniques for combining high-resolution surface images obtained with a Scanning Fiber Endoscope (SFE), and high-resolution penetrating OCT images obtained through Optical Coherence Tomography (OCT), from a SFE, and interleaving frames to improve resolution and identify below surface information of biological structures.

Devices, systems, and methods for stent detection and apposition are disclosed. Embodiments obtain a plurality of images of intravascular image data of a vessel wall and an endovascular device, generate a signal that represents the plurality of images, identify one or more images that correspond to the endovascular device based on the signal that represents the plurality of images, generate a representation of a three-dimensional (3D) shape of the endovascular device based on the one or more images, determine an apposition value of the endovascular device relative to the vessel wall using a representation of a 3D shape of a lumen segment that corresponds to the endovascular device, the apposition value based on a volume difference between the 3D shape of the lumen segment and the 3D shape of the endovascular device, and present information indicating the apposition value.

An ultrasound transducer assembly that includes a piezoelectric layer configured to resonate and generate ultrasound signals around a predetermined ultrasound frequency in which the piezoelectric layer has a width to thickness ratio of at least about 0.6. A conductive matching layer is connected to the top surface of the piezoelectric layer to condition the ultrasound transducer for broad frequency bandwidth operation. A conductive backing layer is connected to the bottom surface of the piezoelectric layer. The ultrasound transducer assembly further includes a rigid body over which the conductive backing layer is positioned, the rigid body assembled for encompassing a central longitudinal axis of a catheter body. A signal and ground electrode may form a metallic layer over the top of or below each of the piezoelectric layers. Electrical waveguides may be connected to corresponding signal and ground electrodes of the transducers.

The present invention provides scanning mechanisms for imaging probes using for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and/or optical coherence tomography. The imaging probes include adjustable rotational drive mechanism for imparting rotational motion to an imaging assembly containing either optical or ultrasound transducers which emit energy into the surrounding area. The imaging assembly includes a scanning mechanism having including a movable member configured to deliver the energy beam along a path out of said elongate hollow shaft at a variable angle with respect to said longitudinal axis to give forward and side viewing capability of the imaging assembly. The movable member is mounted in such a way that the variable angle is a function of the angular velocity of the imaging assembly.