The present invention describes a device (10) for producing a plurality of images for assisting in characterizing skin lesions, the device comprising a capturing unit (1), in particular a video dermatoscope, for selectively illuminating and capturing recordings of an area of skin (11) presenting a skin lesion (12), the capturing unit (1) comprising magnifying optics (2) providing at least 160×, preferably at least 240×, optical magnification of the area of skin (11) for capturing morphological structures of the skin lesion (12); a focusing unit (3) associated with the magnifying optics (2) and configured to place a focal plane (F) of the magnifying optics (2) in a plurality of different depth planes (t1, . . . , tn) below a skin surface of the area of skin (11) starting from the skin surface (t0), preferably in steps; a control unit (4) configured to control the focusing unit (3) and/or the capturing unit (1) and preferably controlling them in such a manner that the capturing unit (1) captures a recording when the focal plane (F) is located in a respective depth plane (t1, . . . , tn); and a processing and output unit (5) for image production based on the image information provided by the capturing unit (1).

A system includes a focus optic configured to converge an electromagnetic radiation (EMR) beam to a focal region located along an optical axis. The system also includes a detector configured to detect a signal radiation emanating from a predetermined location along the optical axis. The system additionally includes a controller configured to adjust a parameter of the EMR beam based in part on the signal radiation detected by the detector. The system also includes a window located a predetermined depth away from the focal region, between the focal region and the focus optic along the optical axis, wherein the window is configured to make contact with a surface of a tissue.

A device for determining the surface topology and associated color of a structure, such as a teeth segment, includes a scanner for providing depth data for points along a two-dimensional array substantially orthogonal to the depth direction, and an image acquisition means for providing color data for each of the points of the array, while the spatial disposition of the device with respect to the structure is maintained substantially unchanged. A processor combines the color data and depth data for each point in the array, thereby providing a three-dimensional color virtual model of the surface of the structure. A corresponding method for determining the surface topology and associate color of a structure is also provided.

A device for viewing a target, the device including a housing, an objective lens positioned within the housing, where the objective lens has a first lens group including at least a first lens and a second lens group including at least a second lens, the first lens positioned closer to the target than the second lens, and a camera positioned within the objective lens between the first lens and the second lens, where the camera is configured to provide images of the target located near a focal point of the objective lens, and wherein the arrangement of the first lens, the second lens, and the camera provides for simultaneous capture of a first image of a surface of the target and a second image of a sub-surface cellular structure of the target.

Disclosed herein are configurations for fiber optic endoscopes employing fixed distal optics and multicore optical fiber.

Systems for generating in-focus color images are provided. Related methods and devices are also provided.

Provided herein are image registration methods comprising providing a wide view image of a target area by a first imager; providing a narrow view image of the target area by a second imager; aligning the narrow view image on the wide view image of the target area; capturing an optical image by an optical imager, wherein the optical imager is configured to locate the optical image in the narrow view image; and displaying the position of the optical image on the narrow view image and the wide view image of the target area; and the systems thereof.

Apparatus and methods for diagnosing conditions consistent with the presence of cranial blood vessel blockage and large vessel occlusions (LVO's) using the framework of a small head-harness that is transportable, field-expedient, and durable. A single pulse set using ultrasonic or near-infrared energy is broadcast into a patient's brain allowing the apparatus to perform an area scan of the brain and detect and decipher cranial blood vessel blockage and LVO signal patterns. The interpretation of the pattern lies within the internal programming which produces a binary signal as to whether an LVO is suspected or not.

Eye fundus inspection apparatus (500) comprising: —illumination means (12) comprising at least a light source (121, 123, 124, 126) and adapted to project a first light beam (1) towards a retina (101) of an eye (100); —an optical lighting path (1A) for said first light beam; —acquisition means (27) adapted to receive a second light beam (2) coming from the retina; —an optical acquisition path (2A) for said second light beam; —scanning means (17) adapted to scan said first light beam (1) on the retina with a linear movement, according to a first scanning direction (S1), or with a circular movement about a rotation axis (A), according to a second scanning direction (S2); —light beam separating means (16) adapted to define separate passage zones for said first and second light beams (1, 2) at a pupil of the eye; —a control unit (120) adapted to control operation of said inspection apparatus; —first light beam shaping means (11) and second light beam shaping means (23, 271, 272) that allow obtaining improved retinal images.

Provided herein are systems, devices, assemblies, and methods for localization of one or more tags in a patient.