A method to form images of internal parts of objects that are of such a nature that images are smeared out due to scattering. The method consists in using scanning beams of radiation, then separating radiation that have not suffered scattering events, from the radiation that have suffered scattering events. The separation between these is made using collimators, which selectively allow only radiation that propagates along the initial propagation direction. The invention also discloses a transparent window pressed against the object, which serves to keep the incident radiation along a known direction. The radiation that suffered scattering may be also used to make a separate image of the internal parts of the object.

Currently most cancers, including breast cancers, are removed without any intraoperative margin control. Post-operative methods inspect 1-2% of the surgical margin and are prone to sampling errors. The present invention relates to an optical imaging system that will enable evaluation of the surgical margin in vivo and in real-time. The invention provides for simultaneous fluorescence and fluorescence polarization imaging. The contrast of the acquired images will be enhanced using fluorescent agents approved for diagnostic use in patients. As the staining pattern of fluorescence images is similar to that of histology, and the values of fluorescence polarization are significantly higher in cancerous as compared to normal cells, the invention provides for further improvements in diagnostic methods. The systems and methods can be applied to the intra-operative delineation of cancerous tissue.

An imaging device includes a body having a first end portion configured to be held in a user's hand and a second end portion configured to direct light onto a surgical margin. The device includes at least one excitation light source configured to excite autofluorescence emissions of tissue cells and fluorescence emissions of induced porphyrins in tissue cells of the surgical margin. A white light source is configured to illuminate the surgical margin during white light imaging of the surgical margin. The device includes an imaging sensor, a first optical filter configured to permit passage of autofluorescence emissions of tissue cells and fluorescence emissions of the induced porphyrins in tissue cells to the imaging sensor, and a second optical filter configured to permit passage of white light emissions of tissues in the surgical margin to the imaging sensor. Systems and methods relate to imaging devices.

The present disclosure provides methods, systems, and devices for coregistering imaging data to form three-dimensional superimposed images of a biological target such as a wound, a tumor, or a surgical bed. A three-dimensional map can be generated by projecting infrared radiation at a target area, receiving reflected infrared radiation, and measuring depth of the target area. A three-dimensional white light image can be created from a captured two-dimensional white light image and the three-dimensional map. A three-dimensional fluorescence image can be created from a captured two-dimensional fluorescence image and the three-dimensional map. The three-dimensional white light image and the three-dimensional fluorescence image can be aligned using one or more fiducial markers to form a three-dimensional superimposed image. The superimposed image can be used to track wound healing and to excise cancerous tissues, for example, breast tumors. Images can be in the form of videos.

A device to measure with infrared radiation, then make a projection picture of, blood concentration inside the body of animals. Blood concentration in cancer masses increases, when compared to adjoining tissues, as flesh and bones, also with a disorganized capillary distribution. The device disclosed in this invention makes two types of images, a first image, which we call transmitted image, with infrared radiation that suffered no scattering as it propagates through the body or part of the body, and a second image, which we call scattered image, with radiation that suffered one or more scattering events, as it propagates through the body. Finally, a third image can be made from a combination of the first and second image after a suitable mathematical manipulation of the first and/or second images. Each of the three images may be used as an indication of cancer.

A system and method for determining the presence of cancerous tissue within a tissue cavity is provided. The system includes one or more excitation light sources, a photodetector, a probe, and a system controller. The probe includes an optically transparent probe body configured to fit within the tissue cavity. The system controller is in communication with the excitation light sources, the photodetector, and a memory storing instructions. The instructions when executed cause the system controller to a) control the excitation light sources to produce excitation light beams within the probe body, the excitation light beams operable to produce a response of the tissue to the interrogation and control the photodetector to detect the response and produce signals representative thereof; and b) produce information indicative of a presence of the cancerous tissue using the signals representative of the response.

A smart bra to detect abnormal breast tissue with a plurality of light emitters which transmit near-infrared light into breast tissue and a plurality of light receivers which receive the light after it has passed through breast tissue, wherein changes in light intensity or spectral distribution in the light caused by passing through the breast tissue are used to identify abnormal breast tissue.

This device is a multi-layer smart bra or bra insert for optical detection of breast cancer. It has four layers: an air-gap-reducing layer; an optical layer with a plurality of light emitters and light detectors; an expandable layer; and a structural layer. Light from the light emitters which has been transmitted through and/or reflected from breast tissue and received by the light detectors is analyzed to detect and/or image abnormal breast tissue.

A system for destroying a cancerous tumor. The system includes an electrical probe, an impedance analyzer device configured to be connected to the electrical probe, a DC voltage generator configured to be connected to the electrical probe, and a processing unit connected to the impedance analyzer device and the DC voltage generator. The electrical probe includes a first electrode including a first electrically conductive needle, a second electrode including a second electrically conductive needle with a nanoporous surface placed inside the first electrode, a first electrically insulating layer placed around the first electrode except a first distal end portion of the first electrode, and a second electrically insulating layer placed between the first electrode and the second electrode. The processing unit configured to perform destroying the cancerous tumor by executing processor-readable instructions utilizing the impedance analyzer device and the DC voltage generator.

Cerenkov Emission (CE) during external beam radiation therapy (EBRT) from a linear accelerator (Linac) has been demonstrated as a useful tool for radiotherapy quality assurance and potentially other applications for online tracking of tumors during treatment. However, an overlooked area is the molecular probing of the cancer status during delivery mainly due to the limited detection sensitivity of CE and lack of flexible tools to fit into an already complex treatment delivery environment. Silicon photomultiplier (SiPM) can be used for low light detection due to their extreme sensitivity that mirrors photomultiplier tubes and yet has a form factor that is similar to silicon photodiodes, allowing for improved flexibility in device design. This work assesses the feasibility of using SiPMs to detect CE, interrogate the tumor molecular status during EBRT, and contrast its performance with silicon photodiodes (PDs) available commercially.