A big data artificial intelligence computer system is used for medical care connecting to sensor-equipped smartphones of users of footwear. The footwear has smartphone-connected soles with sensors and configurable structures. The smartphone is also connected to sensors located on the users' body, including proximate to its center of gravity and/or on the head. The web and/or cloud-based computer system is configured to use the big data techniques of machine learning in a database compiled from millions of smartphones to perform operations on billions of data sets from the smartphones of the footwear users. The correlations found from the big data operations provide solutions to medical problems of the footwear users involving their body structure and/or function. The solutions are implemented by configuring the users' footwear soles, including active configuration, including during running and/or walking to optimize corrections to the structure and/or function of their bodies.

Rapid assessment of microcirculation in tissue to realize closed-loop systems is provided. Microcirculatory assessment systems according to embodiments described herein allow a user to assess changes in local blood flow in microvasculature in real-time using conventional electrical techniques. Some embodiments provide a closed-loop system that allows calibrated doses of electrical stimulation to be delivered in a deep brain stimulation (DBS) system depending on blood flow changes (in specific regions of the brain) being fed back to a controller. The approach described here is readily translatable with very minimal changes to existing hardware. Such closed-loop systems will improve the accuracy of electrode placement in DBS surgery and potentially reduce surgery time, optimize the delivery of electrical stimulation, increase battery life of implantable DBS systems, reduce post-surgical visits to medical practitioners and improve the quality of life of patients.

Rapid assessment of microcirculation in tissue to realize closed-loop systems is provided. Microcirculatory assessment systems according to embodiments described herein allow a user to assess changes in local blood flow in microvasculature in real-time using conventional electrical techniques. Some embodiments provide a closed-loop system that allows calibrated doses of electrical stimulation to be delivered in a deep brain stimulation (DBS) system depending on blood flow changes (in specific regions of the brain) being fed back to a controller. The approach described here is readily translatable with very minimal changes to existing hardware. Such closed-loop systems will improve the accuracy of electrode placement in DBS surgery and potentially reduce surgery time, optimize the delivery of electrical stimulation, increase battery life of implantable DBS systems, reduce post-surgical visits to medical practitioners and improve the quality of life of patients.

A dynamic impedance imaging system includes a dynamic impedance imaging sensor, an impedance detection and flow rate measurement module and an electrical impedance tomography (EIT) instrument. The impedance detection and flow rate measurement module is configured to detect an abnormal particle flowing through the dynamic impedance imaging sensor to obtain a flow rate of the abnormal particle, and generate a synchronous trigger signal. The EIT instrument is configured to inject a sinusoidal excitation current into the dynamic impedance imaging sensor under the trigger of the synchronous trigger signal, perform multi-channel interleaved sampling for the abnormal particle according to the flow rate to acquire multi-channel sampled data, and calibrate the multi-channel sampled data to implement impedance tomography imaging for the abnormal particle.

A dynamic impedance imaging system includes a dynamic impedance imaging sensor, an impedance detection and flow rate measurement module and an electrical impedance tomography (EIT) instrument. The impedance detection and flow rate measurement module is configured to detect an abnormal particle flowing through the dynamic impedance imaging sensor to obtain a flow rate of the abnormal particle, and generate a synchronous trigger signal. The EIT instrument is configured to inject a sinusoidal excitation current into the dynamic impedance imaging sensor under the trigger of the synchronous trigger signal, perform multi-channel interleaved sampling for the abnormal particle according to the flow rate to acquire multi-channel sampled data, and calibrate the multi-channel sampled data to implement impedance tomography imaging for the abnormal particle.

Disclosed herein are systems and methods for revascularization assessment. The methods can in some cases include one or more of the steps of measuring blood perfusion as a function of time to obtain time series data, mathematically transforming the time series data into a power spectrum, calculating at least one parameter of the power spectrum within a specific frequency range, and using the at least one calculated parameter as a discriminator for the first population and the second population.

A method of identifying and locating tissue abnormalities in a biological tissue includes irradiating an electromagnetic signal, via a probe defining a transmitting probe, in the vicinity of a biological tissue. The irradiated electromagnetic signal is received at a probe, defining a receiving probe, after the signal is scattered/reflected by the biological tissue. Blood flow information pertaining to the biological tissue is provided. Based on the received irradiated electromagnetic signal and the blood flow information, tissue properties of the biological tissue are reconstructed. A tracking unit determines the position of at least one of the transmitting probe and the receiving probe while the step of receiving is being carried out, the at least one probe defining a tracked probe. The reconstructed tissue properties are correlated with the determined probe position so that tissue abnormalities can be identified and spatially located.

A method of identifying and locating tissue abnormalities in a biological tissue includes irradiating an electromagnetic signal, via a probe defining a transmitting probe, in the vicinity of a biological tissue. The irradiated electromagnetic signal is received at a probe, defining a receiving probe, after the signal is scattered/reflected by the biological tissue. Blood flow information pertaining to the biological tissue is provided. Based on the received irradiated electromagnetic signal and the blood flow information, tissue properties of the biological tissue are reconstructed. A tracking unit determines the position of at least one of the transmitting probe and the receiving probe while the step of receiving is being carried out, the at least one probe defining a tracked probe. The reconstructed tissue properties are correlated with the determined probe position so that tissue abnormalities can be identified and spatially located.

A ventricular shunt device, such as a ventriculoperitoneal (“VP”) shunt, comprising an electromagnetic flow meter attachment, in aspects attachable to pre-existing peritoneal catheters systems, providing for the capability for physicians to obtain information about the status of the VP shunt and its functionality. Due to the high failure rate of current shunt catheters and the associated dangers with shunt failure, the need for real-time monitoring is ever present. A Halbach cylinder or other electromagnetic system or array is implemented to generate a magnetic field to observe flow rates through the peritoneal catheter to serve certain functions, as well as associated applications and verification of the device in computational and experimental settings.

A removable smartphone case is disclosed. The removable smartphone case includes a case body configured to receive a smartphone, a radio frequency (RF) front-end connected to the case body and including a semiconductor substrate, at least one transmit antenna configured to transmit radio waves below the skin surface of a person, and a two-dimensional array of receive antennas configured to receive radio waves, the received radio waves including a reflected portion of the transmitted radio waves, wherein the semiconductor substrate includes circuits configured to generate signals in response to the received radio waves, a digital baseband system configured to generate digital data in response to the signals, wherein the digital data is indicative of a health parameter of the person, and a communications interface configured to transmit the digital data generated by the semiconductor substrate from the removable smartphone case.