The present invention relates to a method of adding an anticoagulant to the blood of a patient, wherein the addition takes place in the form of a bolus, wherein the bolus application time B depends on the values TBV and CO, with TBV representing the blood volume of the patient and CO the cardiac output of the patient. The present invention furthermore relates to an apparatus for adding a coagulant to the blood of a patient.

Devices, systems, and methods are disclosed. The devices, systems, and methods detect one or more parameters with respect to movement of a user, cardiac activity of the user, audio associated with the user, or a combination thereof during a sleep session of the user; process the one or more parameters to determine a sleep status of the user, the sleep status being at least one of awake, asleep, or a sleep stage; and calculate an apnea-hypopnea index for the user during the sleep session based, at least in part, on the sleep status.

The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).

The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).

Method and apparatus obtain information about a patient and/or a respiratory therapy system that is configured to deliver respiratory therapy to the patient. The respiratory therapy system may include a flow generator configured to generate a supply of pressurized air along an air circuit to a patient interface. A sound signal representing a sound in the air circuit may be processed to obtain cepstrum data. A time series of delay estimates based on acoustic signatures of the cepstrum data may be generated. Each acoustic signature may represent a reflection of sound from a patient interface along the air circuit. Variation in the time series of delay estimates may be analysed. One or more output indicators based on the variation may be generated. The one or more output indicators may concern patient and/or system status.

The present application describes a PHHM of the type described in WO 2013/002165, WO 2014/125431 and International Patent Application No. PCT/EP2015/079888 with improved aspects to find indicators of health, and other improvements that facilitate its construction and calibration.

Embodiments of the present disclosure relate to a system and method for determining a risk, onset, or presence of hypovolemia based on one or more features of a plethysmographic waveform during a patient breathing cycle. For example, a hypovolemic patient may exhibit characteristic changes in pulse amplitude or stroke volume during inhalation and exhalation relative to a healthy patient. Further, a trend or pattern of such features may be used to assess the patient's fluid condition.

Embodiments of the present disclosure relate to a system and method for determining a risk, onset, or presence of hypovolemia based on one or more features of a plethysmographic waveform during a patient breathing cycle. For example, a hypovolemic patient may exhibit characteristic changes in pulse amplitude or stroke volume during inhalation and exhalation relative to a healthy patient. Further, a trend or pattern of such features may be used to assess the patient's fluid condition.

An apparatus for monitoring a patient post operation having electrically conducting leads which are adapted to extend from inside the patient. The leads having electrodes adapted to communicate with a heart of the patient and apply electrical signals to the heart. The electrodes providing cardiac signals to the computer in response to the electrical signals so the computer can determine in real time at least one of heart volume, end diastolic heart volume, end systolic heart volume, stroke volume, change in heart volume, change in stroke volume, contractility, respiration rate or tidal volume regarding the patient.

The present technology relates to interatrial shunting systems and methods. In some embodiments, the present technology includes interatrial shunting systems that include a shunting element having a lumen extending therethrough that is configured to fluidly couple the left atrium and the right atrium when the shunting element is implanted in a patient. The system can also include an energy receiving component for receiving energy from an energy source positioned external to the body, an energy storage component for storing the received energy, and/or a flow control mechanism for adjusting a geometry of the lumen.