Equipment for carrying out cardiac autonomic neuropathy tests includes a base unit to which a mouthpiece is connected, forming an autonomous system for measuring the pressure and/or the pattern of breath, provided with a series of LEDs aimed at informing a patient, who is undergoing the test, about correctness or incorrectness of a test execution. The mouthpiece is provided with a flow sensor, aimed at measuring a patient's pattern of breath, and a pressure sensor. The mouthpiece includes also an atmospheric pressure sensor aimed at measuring the environmental pressure. The equipment includes also a sensor, aimed at measuring the heartbeat, applied by simple contact to the patient's wrist area, and an orthostatic measuring device aimed at measuring any change of the patient's position. Data can be introduced or analysed and the type of exam to do can be selected. Results of the tests can be stored in a memory.

The present invention is a wearable device for comprehensive bio-monitoring of physiologic metrics to determine metabolic, pulmonary and cardiac function and oxygen saturation measurements from breathing mask apparatuses. The device non-invasively monitors the physiologic profile of the subject, and is capable of detecting physiologic changes, predicting onset of symptoms, and alerting the wearer or another person or system. In some embodiments, the device comprises both a wearable sensor suite and a portable gas composition and flow analysis system. In preferred embodiments, it comprises a miniaturized non-invasive sensor suite for detecting physiologic changes to detect dangerous breathing or other health conditions. The system utilizes advanced fast-response sensors with improved efficiency and lifespan, and provides rapid analysis for substantially real-time monitoring of the subject's present condition to predict, mitigate and/or prevent the onset of dangerous conditions.

The chronic nature of asthma necessitates regular self-monitoring of respiratory function in susceptible individuals, however the available devices for performing the necessary measurements are either inaccurate or expensive and bulky. The present invention provides a small, cheap spirometer for efficient, accurate and convenient measurement of breathing characteristics.

Provided according to embodiments of the invention are photoplethysmography (PPG) sensors, systems and methods of using the same. In some embodiments of the invention, methods of obtaining a photoplethysmography (PPG) signals include securing a PPG sensor onto a nasal columella of an individual; and obtaining a PPG signal from the PPG sensor.

A non-dispersive multi-channel radiation sensor assembly includes a beamsplitter assembly, a first band-pass filter, which has a predefined first bandwidth and has a transmission maximum at a predefined first useful-signal wavelength, a first measurement-radiation useful-signal sensor, which is arranged downstream of the first band-pass filter in the beam path, a second band-pass filter, which has a transmission maximum at a predefined first reference-signal wavelength, a first measurement-radiation reference-signal sensor, which is arranged downstream of the second band-pass filter in the beam path. The beamsplitter assembly has a first irradiation region and a second irradiation region, in which irradiation regions the beamsplitter assembly is irradiated with measurement radiation. The irradiation regions are optically designed in such a way that the beamsplitter assembly deflects, in the first irradiation region, a first part of the measurement radiation onto the first band-pass filter and a second part of the measurement radiation onto the second band-pass filter.

A personalized drug delivery apparatus comprising drug containing means; a spout configured to receive full lung exhalation; a mechanism configured to determine a personalized drug dosage according to the exhalation, the spout further configured to enable inhalation of the determined dosage.

There are provided Nano-Opto-Mechanical sensors for measuring concentration of a component in a gas flow, methods for their use and system comprising the same.

A capnoscope assembly for measuring carbon dioxide (CO2) concentration, and an associated method. The assembly includes a detection unit, an indicator holder, a processing unit, and a calibration member. The processing unit adjusts light parameters such that a camera detects a predetermined calibration colour. A colorimetric indicator is arranged to be used in the indicator holder. The colour of the colorimetric indicator surface is measured when illuminated by emitted light being generated by using determined calibrated control signal values, when no CO2 is present. The measured colour is stored as a zero CO2 colour value. A CO2 concentration relationship is determined based upon the measured zero CO2 colour value. The processing unit applies the CO2 concentration relationship during CO2 concentration measurements provided that the determined calibrated control signal values are applied when emitting light.

A medication delivery system including a holding chamber having an input and an output end, a backpiece coupled to the input end of the holding chamber and having an electrical circuit and an opening. An MDI includes an insert portion moveable between an engaged position wherein the insert portion is received in the opening and a disengaged position wherein the insert portion is removed from the opening, and at least one contact that completes the electrical circuit when the insert portion is in the engaged position.

Methods and systems estimate cardio-respiratory parameter(s), such as from in-phase and quadrature channels. The channels may represent patient chest movement and may be generated with a sensor, such as a contactless sensor that may sense movement with radio-frequency signals. In the methods/systems, the in-phase and quadrature channels may be processed, such as in a processor(s), using relative demodulation to generate cardio-respiratory parameter estimate(s). Optionally, the processing produces a jerk signal that may be filtered for producing a heart rate estimate, such as from zero-crossings of the filtered signal. Optionally, the processing produces a chest velocity signal that may be filtered for producing a respiratory rate estimate, such as from zero-crossings of the filtered signal. Optionally, a respiratory volume, such as tidal volume, may be estimated from an intrapulmonary pressure signal generated by applying a function to a chest displacement signal where the function relates intrapulmonary pressure and chest displacement.