A wearable device for non-invasive monitoring of the presence, amount, and/or concentration of an analyte in a sample from a user of the device is described. The analyte is selected to be indicative of or related to a physiological status of a user. Relevant physiological status include hypoglycemia, infection, respiratory infection, urinary infection, gastrointestinal infection, obesity, diabetes, type I diabetes and type II diabetes.

The present disclosure provides a resonator system for detecting perspiration. The system includes a resonator. The resonator includes an electronically conductive segment. The resonator further includes a polymeric component coating at least a portion of the electronically conductive segment. The resonator further includes a fluidic channel component positioned adjacent to the polymeric component and comprising a microfluidic channel.

Some embodiments relate to a reconfigurable biosensor adapted for performing tests in a plurality of modes or a smartphone or wearable device comprising the reconfigurable biosensor.

Methods, structures, devices and systems are disclosed for fabricating and implementing electrochemical biosensors and chemical sensors. In one aspect, a method of producing an epidermal biosensor includes forming an electrode pattern onto a coated surface of a paper-based substrate to form an electrochemical sensor, the electrode pattern including an electrically conductive material and an electrically insulative material configured in a particular design layout, and attaching an adhesive sheet on a surface of the electrochemical sensor having the electrode pattern, the adhesive sheet capable of adhering to skin or a wearable item, in which the electrochemical sensor, when attached to the skin or the wearable item, is operable to detect chemical analytes within an external environment.

An epidermal biosensor comprising a diffusion layer operable to dissolve a solid-phase epidermal analyte, an enzymatic bioreceptor operable to oxidise the dissolved epidermal analyte from the diffusion layer, a transducer having an interface with the diffusion layer, a processor configured to process electrochemical data from the transducer, and a substrate to which the enzymatic bioreceptor and the transducer are attached. The solid-phase epidermal analyte may include water-insoluble cholesterol and water-soluble lactate. The diffusion-solvation layer may comprise agarose hydrogel and additives including glycerol and/or gelatin to improve mechanical robustness and reduce water evaporation rate of the hydrogel, and ethanol and/or Triton X-100 to facilitate solvation and transportation of hydrophobic analytes.

A wearable sensor system includes a flexible patch, an electronic circuit disposed on the flexible patch, and a disposable sensor disposed on the flexible patch and connected to the electronic circuit via a socket. The disposable sensor detects a chemical compound. The electronic circuit generates a detection signal commensurate with the chemical compound detected by the disposable sensor. The disposable sensor is removably plugged into the socket, thereby permitting replacement of the disposable sensor upon satisfaction of a predetermined condition. A battery disposed is on the flexible patch and connected to the electronic circuit to power the electronic circuit. A transceiver is connected to the electronic circuit, wherein the transceiver transmits the detection signal.

The invention provides a versatile sensing platform for sensing and analysis of biofluids, particularly well-suited for sensing and analysis of sweat. Systems of the invention allows for sensitive and selective detection of a range of analytes in sweat including metabolites, electrolytes and biomarkers. Systems of the invention provide a noninvasive and accurate means for quantitative characterization of important sweat characteristics including sweat volume, sweat loss and sweat rate. Systems of the invention are compatible with materials and device geometries for important class of conformal tissue mounted electronic devices, including epidermal electronic devices.

A method for quantifying a content of hydrophobic components contained in a liquid using a contact area diffusion factor (CADF) of a droplet of the liquid to a solid surface is provided. In addition, the obtained content of the hydrophobic components provides information about prediction for possibility of developing a metabolic disease or dementia, or information about the incidence or progression of a metabolic disease or dementia.

The present invention refers to a microfluidic system based on passive capillary valves and pumps, that allows a discontinuous and autonomous measurement process for extensive periods of time. The microfluidic system comprises: at least one measuring chamber, at least one inlet for the input of a biofluid, a microfluidic intake channel fluidly communicating the inlet with the measuring chamber, at least one sensor suitable for measuring a parameter of an analyte of a biofluid. A passive fluid pump is fluidly communicated with the measuring chamber, and it is adapted to generate a capillary pressure greater than the biofluid generation pressure. A retention valve is interposed between the measuring chamber and the fluid pump, and the retention passive valve is configured to stop flow of biofluid for a certain period of time, when the measuring chamber if filled with biofluid. The invention provides a robust device, capable of collecting and conveying a biofluid, preferably sweat, for repetitive and electrochemical measurements.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.