Method and apparatus for receiving a first signal indicative of first glucose levels measured by a first working electrode, receiving a second signal indicative of second glucose levels measured by a second working electrode, detecting a first decrease in an amplitude of the first signal measured by the first working electrode that exceeds a first threshold, detecting a second decrease in an amplitude of the second signal measured by the second working electrode that exceeds the first threshold, selecting the first signal based on determining that the first decrease in the amplitude of the first signal is less than the second decrease in the amplitude of the second signal, determining a rate of change corresponding to the first decrease in the amplitude of the first signal, comparing the rate of change to a second threshold, confirming, based on the comparison, that the first signal is valid.

Health and care are improved with a portable catabolic marker measuring unit. In one example a unit includes a case, a catabolic marker sensor in the case to measure a concentration of a catabolic marker in a user in vivo, and a proximity sensor in the case to determine whether the catabolic marker sensor is near the user, wherein the catabolic marker sensor measures the concentration in response to the determining that the catabolic marker sensor is near the user.

Provided herein are methods, devices, and systems that pertain to solid-state sensor and sensor-reading meter for touch-based rapid physiological and chemical sensing.

Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including patches and corresponding modules for wirelessly monitoring physiologic and/or physical signals is disclosed. A service system for managing the collection of physiologic data from a customer is disclosed. An isolating patch for providing a barrier between a handheld monitoring device with a plurality of contact pads and a subject is disclosed.

A microfluidic device for detecting biomolecules in sweat, and a biosensor patch for detecting biomolecules in sweat, in which the microfluidic device and a biosensor are combined, the device and the patch being capable of detecting various target molecules present in sweat by electrochemical signals and also detecting the concentration of a target molecule.

A system with an analyzer device in fluid communication with a sample of a bodily fluid is configured to chemically or electrochemically convert at least a portion of ammonium (NH.sub.4.sup.+) contained within the bodily fluid into ammonia (NH.sub.3) and dispel the converted ammonia (NH.sub.3) into a gas sensing chamber. An ammonia (NH.sub.3) sensor located within the gas sensing chamber in conjunction with a processor can quantify an amount of ammonia (NH.sub.3) present in the gas sensing chamber in relation to the total ammonia of the bodily fluid.

The present invention relates to devices and methods for uptaking and analyzing sweat from a skin of a user. In particular, it is proposed to provide a variability in the size of the sweat sensor inlets (102, 103, 104), which can be used for improving the determination of sweat parameters like for example determining the number of active sweat glands The variability in the size of the inlets (102, 103, 104) with which the sweat sensor (100) uptakes the sweat from the user's skin (111) can be achieved by having either plurality of inlets wherein at least some of them have different opening sizes and to use the differently sized inlets based in different situations. Alternatively, one or more inlets may have openings with variable cross-sectional area, like e.g. an adjustable diameter of their opening, and also a combination of these two alternatives is of course possible. A processor of the sweat sensor may use the information from either all or only the most appropriate sized inlets to determine a sweat parameter. In another alternative, the processor may adapt the inlet to the adjustable inlet opening to the most appropriate size to then determine a sweat parameter of interest.

The disclosed technology provides a system and a computer implemented method for crisis state detection and intervention of a person or group of persons, the method comprising: providing a computer system designed to detect and intervene non-normal, elevated crisis operating states; using one or more biometric sensors that ascertains a crisis state via physical, behavioral, or mental indicators; deducing, with computational hardware, the operational state of a user or users from one or more biometric sensors; and administering an immediate, dual intervention of a sensory form to de-escalate the crisis operating state of a person or group of persons.

Disclosed are devices, systems and methods for epidermal monitoring of a fluid on skin. In some aspects, a device includes an electrochemical sensor comprising two or more electrodes disposed on a first flexible substrate; a microfluidic device comprising a second flexible substrate coupled to the first substrate and structured to include (i) a channel in a first cavity of the second substrate, (ii) one or more holes that connect to the channel and provide one or more inlets, and (iii) a reservoir connected to the channel, in which the electrochemical sensor is aligned with the reservoir; and an adhesion layer coupled to the microfluidic device and attachable to skin, and the device being operable to detect a biomarker in a fluid in secreted by the skin into the microfluidic device.

Typical electrochemical sensors measure target-induced changes in current output. Such measures of target binding are inconsistent across individual sensors, and furthermore, signal will drift over time when the sensor is deployed for long periods. These shortcomings can be avoided by the novel use of chronoamperometry to measure current decay kinetics as the indicator of target binding. Current decay lifetimes will vary in a concentration dependent manner, but remain stable across individual sensors and over time, allowing for calibration-free operation. By these methods, aptamer based electrochemical sensors and other sensor types may be deployed in vivo for extended periods of time and will provide accurate measurement of target binding without calibration.