Provided herein are flexible, microfluidic epidermal systems and methods useful in the analysis of biofluids for biomarkers corresponding to a variety of conditions and methods of use. The provided systems configured to create conformal contact with the skin to allow for medical testing or screening, either in situ or later external laboratory testing. The described devices and methods may be used for cystic fibrosis screening, glucose monitoring, drug and/or alcohol testing, creatinine monitoring, urea monitoring, pH measurement and dialysis treatment efficacy testing.

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

The present invention presents a method of fabrication for a physiological sensor with electronic, electrochemical, and chemical components. The fabrication method comprises steps for manufacturing an apparatus comprising at least one electrochemical sensor, a microcontroller, and a transceiver. The fabrication process includes the steps of substrate fabrication, circuit fabrication, pick and place, reflow soldering, electrode fabrication, membrane fabrication, sealing and curing, layer bonding, and dressing. The physiological sensor is operable to analyze biological fluids such as sweat.

Embodiments are related to a headset integrated into a healthcare platform. The headset comprises one or more sensors embedded into a frame of the headset, a controller coupled to the one or more sensors, and a transceiver coupled to the controller. The one or more sensors capture health information data for a user wearing the headset. The controller pre-processes at least a portion of the captured health information data to generate a pre-processed portion of the health information data. The transceiver communicates the health information data and the pre-processed portion of health information data to an intermediate device communicatively coupled to the headset. The intermediate device processes at least one of the health information data and the pre-processed portion of health information data to generate processed health information data for a health-related diagnostic of the user.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

The present invention provides an integrated sweat sensing system including a multi-layered structure incorporating a flexible circuitry sensing layer with multiple electronic and mechanical components responsible for sensing certain physiological changes of a user and giving feedback signals to the user when a detectable biological, chemical or physiological signal exceeds certain threshold. The system further includes a microfluidic based biosensing platform responsible for sensing changes in sweat component composition including ions, glucose and pH changes, and subsequently trigger feedback signal outputs from the flexible circuitry sensing layer to provide the user with a corresponding change-of-state signal. The present system is bendable and detachably mountable on various skin regions of the user.

Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including patches and corresponding modules for wirelessly monitoring physiologic and/or physical signals is disclosed. A service system for managing the collection of physiologic data from a customer is disclosed. An isolating patch for providing a barrier between a handheld monitoring device with a plurality of contact pads and a subject is disclosed.

Disclosed is a hormone electrochemical biosensor, e.g. an amperometric biosensor, for the detection of a hormone and measurement of the concentration of a hormone. The disclosed hormone biosensor comprises a hormone-catalyzing enzyme, such as KSDH1. Also described herein are systems comprising an amperometric biosensor, e.g., chronoamperometric biosensor and methods of using the chronoamperometric biosensor.

A computer system provides biometric-based distress detection and assistance. Biometric information that is associated with an entity and audio data associated with an environment of the entity are received. A distress score is calculated based on the biometric information. The audio data is analyzed to identify one or more distress factors. In response to determining that the distress score exceeds a distress threshold and in response to identifying the one or more distress factors, a notification that the entity requires aid is transmitted to a third party. Embodiments of the present invention further include a method and program product for providing biometric-based distress detection and assistance in substantially the same manner described above.

A wearable sensor includes: a base member that has a through hole serving as a flow path of liquid and a recess connecting with an end portion of the through hole on an outlet side; a water absorbing structure disposed on a surface of the base member on the outlet side to come into contact with the liquid flowing into the recess from an opening of the through hole on the outlet side; a laser diode that radiates light toward the liquid flowing into the recess from the opening of the through hole on the outlet side; and a photodiode that receives light from the laser diode transmitted through the liquid or light reflected by the liquid. An amount of perspiration of a wearer of the wearable sensor is calculated based on light receiving characteristics of the photodiode.