A non-invasive device for measuring concentration levels of optically active substances, such as glucose, by determination of polarization plane turn angle in the infrared spectrum. Instant embodiments, measuring optical polarization shift, include a narrow-band optical source having a first linear polarizer; substantially illuminated by the source, a sample stage capable of temporarily immobilizing a sample; proximate to the sample stage and within a predetermined angular range with respect to the source illumination of the sample, a narrow-band optical detector capable of detecting polarization angles from the illuminated sample; and in conjunction with the source and the detector, a linear polarization angle comparator for comparing a polarization of the source with a polarization maxima region measured by the detector.

A measuring chamber device for an optically operating sensor for determining a concentration of a substance that is contained in tissue fluid of a mammal. The measuring chamber device has a measuring chamber filled with a liquid measuring medium and a wall with better diffusion permeability for the substance than for other constituents of the tissue fluid. A transmitter device for emitting optical radiation into the measuring chamber, and a receiver device for receiving optical radiation that has passed through the measuring chamber are also provided.

A device, system and method of non-invasive monitoring of physiological measurements of a subject are disclosed. The method may include: emitting light beams towards skin of the subject, with at least one light source having at least one predetermined polarization, wherein the light beams are emitted at an angle 0°≤α<90° relative to the normal to the skin surface of the subject; sensing light beams with at least one light sensor positioned at a predetermined distance from the at least one light emitting source; filtering out signals corresponding to detected light beams based on the at least one predetermined polarization of the at least one light source; and determining at least one physiological signal, based on the sensed light beams after filtering. The sensed light beams may pass through at least one of epidermis, dermis, subcutaneous tissue and blood vessel of the subject.

A patient monitoring sensor having a communication interface, through which the patient monitoring sensor can communicate with a monitor is provided. The patient monitoring sensor includes one or both of waveguide-based light emitter and detector, communicatively coupled to the communication interface, capable of detecting light.

Implantable device for measuring the glucose concentration of a body fluid when implanted, the device comprising a glucose measurement unit, the glucose measurement unit comprising a light source configured to emit light towards a light transmissive part of a housing of the device, the device further comprising an optical sensor configured to detect light returned through the transmissive part from the light source, and output an electrical signal based on the detected light, and a wireless communication module configured to wirelessly communicate with an external wireless communication device, wherein the wireless communication module is configured to wirelessly transmit a signal based on the electrical signal to the external wireless communication device.

A sensor device includes a housing defining a cavity, an inlet to receive fluid pumped from an instrument device, an outlet to return the fluid to a fluid reservoir, and a fluid channel defined inside the cavity between the inlet and the outlet. A heat pump is mounted inside the cavity, and has a side surface thermally coupled to the fluid channel and an opposite side surface thermally coupled to a plate. The heat pump is configured to induce a temperature change. A sensor unit is aligned with an aperture in the plate and includes an optical component and a thermal component. The optical component configured to measure a vascular endothelial response from the induced temperature change.

In some embodiments, an apparatus for imaging blood within a target region of tissue includes an imaging device configured to output image data associated with light received by the imaging device having a first and second spectral ranges, wherein the absorptivity by blood of light having the first spectral range is less than the absorptivity by blood of light having the second spectral range, and a controlling element configured to capture the image data associated with light received by the imaging device and to process the captured image data associated with light having the first spectral range and the captured image data associated with light having the second spectral range to generate compound image data associated with an amount of blood within the target region of tissue.

Provided is a contactless internal measurement device including an electromagnetic wave irradiation unit that irradiates an electromagnetic wave to a measurement subject, and an electromagnetic wave receiver that detects the electromagnetic wave reflected by the measurement subject. The electromagnetic wave irradiation unit is disposed to reduce a polarization component of the electromagnetic wave detected by the electromagnetic wave receiver, the polarization component being the same as a polarization component of the electromagnetic wave irradiated by the electromagnetic wave irradiation unit.

The invention provides a system (1) comprising a sensor (100) for measuring a skin parameter, the sensor (100) comprising a plurality of spatially separated light sources (110) configured to provide light source light (111), and one or more detectors (120) configured at a first distance (d1) from each of the light sources (110), wherein the first distance (d1) is selected from the range of 5-80 mm, wherein the sensor (100) is configured to provide the light source light (111) with optical axes (OL) under an angle (a) relative to an optical axis (O2) of the one or more detectors (120) selected from the range of 10-80°, wherein the sensor (100) comprises at least three light sources (110), wherein the light sources (110) are configured to provide unpolarized light source light (111), wherein the system (1) further comprises an analysis system (2) wherein the analysis system (2) is configured to generate a corresponding skin sensor value on the basis of a detector response of the one or more detectors (120) at one or more wavelengths selected from a spectral range of 350-780 nm.

The present invention relates to a device, system and method for extracting physiological information indicative of at least one vital sign of a subject. To solve the motion robustness problem of known solutions, the device comprises a pre-treatment unit (210) configured to derive at least three detection signals from electromagnetic radiation reflected from a skin region of a subject, wherein at least two detection signals comprise wavelength-dependent reflection information in a different wavelength channel and at least two detection signals comprise reflection information in different polarization channels having different polarization directions. This provides that a channel that always has a low pulsatility, even when the SpO2 value is low. This channel mainly contains the motion-induced distortions. Adding this always low-pulsatile channel to the generally known PBV pulse extraction or the ABPV SpO2 measurement algorithm, or replacing an existing channel solves the reduced motion robustness problem of the known systems and methods.