A technique for correlating electroencephalogram (EEG) with diffusion tensor imaging (DTI) and magnetoencephalography (MEG) to place probes in optimal locations and generate 4D maps of neuronal activity in the brain is presented. EEG and MEG probes may be positioned relative to tract clusters based on a volumetric isotropic sequence and a DTI sequence. Each probe may include multiple electrodes. The probes may be associated with a helmet on which probe position is automatically adjusted. A baseline map may be compared with a pathological state map to aide in characterizing neurological function and disorder.

An ultrasound device for modulating brain activity may include a body and components for activating the brain. Such components include ultrasound transducers. The devices are used to provide ultrasound waves to brain structures in a subject wearing a device for methods to treat traumatic brain injury, affect postural control, affect wakefulness, attention, and alertness, to provide memory control, to alter cerebrovascular hemodynamics, to minimize stress, and to reinforce behavioral actions.

An ultrasound device for modulating brain activity may include a body and components for activating the brain. Such components include ultrasound transducers. The devices are used to provide ultrasound waves to brain structures in a subject wearing a device for methods to treat traumatic brain injury, affect postural control, affect wakefulness, attention, and alertness, to provide memory control, to alter cerebrovascular hemodynamics, to minimize stress, and to reinforce behavioral actions.

Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.

Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.

A method and system for neuromodulation therapy is described. One or more psychophysiological parameters based on an electrical signal of a user's brain activity are determined and used to generate a neuromodulation marker using a neuromodulation recipe. The neuromodulation marker may be determined using statistical estimates of the psychophysiological parameters in relation to a reference distribution. Feedback is then provided to the user based on the neuromodulation marker. Weighting parameters may be used to vary the neuromodulation recipe and personalize the neuromodulation therapy in response to performance or user input.

Abnormalities in electromagnetic fields in the heart, brain, and stomach, among other organs and tissues of the human body, can be indicative of serious health conditions. Described herein are methods, software, systems and devices for detecting the presence of an abnormality in an organ or tissue of a subject by analysis of the electromagnetic fields generated by the organ or tissue.

Abnormalities in electromagnetic fields in the heart, brain, and stomach, among other organs and tissues of the human body, can be indicative of serious health conditions. Described herein are methods, software, systems and devices for detecting the presence of an abnormality in an organ or tissue of a subject by analysis of the electromagnetic fields generated by the organ or tissue.

A computer system receives a plurality of signals corresponding to first time-series magnetic data generated from a plurality of unshielded magnetometers proximate to the human subject. The first time-series magnetic data corresponds to magnetic fields generated from the human subject. The plurality of signals includes contributions from a biomagnetic field from at least a portion of the subject's organ and a background magnetic field. The computer system synchronizes the first time-series magnetic data to a common clock to generate synchronized time-series magnetic data. The computer system applies one or more filters to the synchronized time-series magnetic data to obtain filtered data. The computer system applies one or more noise reduction techniques to the filtered data to generate updated time-series magnetic data.

An apparatus for measuring magnetic fields from a subject's organ comprises a plurality of unshielded magnetometers in a three-dimensional arrangement. A respective pair of magnetometers, in the plurality of magnetometers, has a respective known separation. Each magnetometer in the plurality of magnetometers is configured to simultaneously detect a biomagnetic field from at least a portion of the subject's organ and a background magnetic field and output a signal indicative of the detected biomagnetic field and the background magnetic field.