A sensor array comprises a base for providing a probe signal and a plurality of modular recording sites. Each modular recording site of the plurality of modular recording sites is configured for receiving a signal, for converting the signal into a digital sensor signal using an in-situ analog-to-digital converter and to provide the digital sensor signal to the base using a communication interface. The communication interfaces of the plurality of modular recording sites are connected serially with respect to each other and to the base and each in-situ analog-to-digital converter is configured for operating in a first operating mode and in a second operating mode. The base is configured for receiving a plurality of digital sensor signals from the plurality of modular recording sites and to process the plurality of digital sensor signals so as to provide the probe signal.

Provided herein is a mesoscopic electrophysiological system including a structural system sized and configured to be attached to a head of a patient and to hold a plurality of intracranial electrode shafts in predetermined positions around the head of the patient, a plurality of mesoscopic intracranial electrode shafts that includes a first plurality of electrode contacts configured to measure local field potentials (LFPs) at a plurality of locations in a brain of a patient, wherein each electrode shaft of the plurality of intracranial electrode shafts includes a second plurality of electrode contacts, and a plurality of guide pins sized and configured to receive the plurality of mesoscopic intracranial electrode shafts positioned therein.

Provided herein is a mesoscopic electrophysiological system including a structural system sized and configured to be attached to a head of a patient and to hold a plurality of intracranial electrode shafts in predetermined positions around the head of the patient, a plurality of mesoscopic intracranial electrode shafts that includes a first plurality of electrode contacts configured to measure local field potentials (LFPs) at a plurality of locations in a brain of a patient, wherein each electrode shaft of the plurality of intracranial electrode shafts includes a second plurality of electrode contacts, and a plurality of guide pins sized and configured to receive the plurality of mesoscopic intracranial electrode shafts positioned therein.