A system for performing fluid level measurements on a biological subject, the system including at least one substrate including a plurality of microstructures configured to breach a stratum corneum of the subject, at least some microstructures including an electrode, a signal generator operatively connected to at least one microstructure to apply an electrical stimulatory signal to the at least one microstructure and at least one sensor operatively connected to at least one microstructure, the at least one sensor being configured to measure electrical response signals from at least one microstructure. The system also includes one or more electronic processing devices that determine measured response signals, the response signals being at least partially indicative of a bioimpedance and perform an analysis at least in part using the measured response signals to determine at least one indicator at least partially indicative of fluid levels in the subject.

Integrated electronic circuit (10,12) for an implantable probe module, including a number of pixel circuits each having: an electrode for contacting a biological tissue; a biasing stage (M.sub.1,C) with a capacitor and a first transistor, which is coupled to the capacitor and injects in an input node (N.sub.IN) a biasing current (I.sub.bias) that depends upon the charge of the capacitor; a second transistor coupled to the electrode and to the input node (N.sub.IN); an amplifier coupled to a reference voltage (V.sub.ref1) and to the input node (N.sub.IN). The integrated electronic circuit (10,12) furthermore includes a feedback stage electrically controllable so as to be alternatively coupled or decoupled from each pixel circuit. The feedback stage forms, when coupled to a pixel circuit, an autozeroing loop that charges the corresponding capacitor so that the biasing current (I.sub.bias) is such that on the input node (N.sub.IN) a voltage substantially equal to the reference voltage is present.

Integrated electronic circuit (10,12) for an implantable probe module, including a number of pixel circuits each having: an electrode for contacting a biological tissue; a biasing stage (M.sub.1,C) with a capacitor and a first transistor, which is coupled to the capacitor and injects in an input node (N.sub.IN) a biasing current (I.sub.bias) that depends upon the charge of the capacitor; a second transistor coupled to the electrode and to the input node (N.sub.IN); an amplifier coupled to a reference voltage (V.sub.ref1) and to the input node (N.sub.IN). The integrated electronic circuit (10,12) furthermore includes a feedback stage electrically controllable so as to be alternatively coupled or decoupled from each pixel circuit. The feedback stage forms, when coupled to a pixel circuit, an autozeroing loop that charges the corresponding capacitor so that the biasing current (I.sub.bias) is such that on the input node (N.sub.IN) a voltage substantially equal to the reference voltage is present.

An implantable medical device for sensing physiological signals comprises an arrangement of at least a first electrode pole, a second electrode pole and a third electrode pole, said arrangement of at least the first, second and third electrode poles being configured to sense physiological signals. The implantable medical device further comprises a processing module for processing signals received via said arrangement of at least the first, second and third electrode poles. The processing module is configured to monitor cardiac activity based on a first signal received by a first pair of electrode poles of the arrangement of at least the first, second and third electrode poles and to assess a consistency of said first signal based on a second signal received by a second pair of electrode poles of the arrangement of at least the first, second and third electrode poles different then said first pair.

Biometric information about a person may be collected and analyzed to gain insight into the person's physical and/or emotional conditions. The collection and analysis may be performed using a uniquely designed sensing device that includes multiple sets of sensors configured to collect EEG, EOG, EMG, EDA, and/or PPG signals from the person's head and/or facial areas. The sensing device may include a multi-layered facepad and may be coupled to a VR/AR headset and/or a scalp engagement apparatus to monitor the person's physiological and/or neural reactions to audio/visual stimuli.

According to some embodiments, a device for sensing neuromuscular signals is provided. The device may comprise a plurality of signal electrodes aligned along an interior portion of a wearable structure, each signal electrode being configured to detect neuromuscular signals. The device may comprise a plurality of amplifiers, wherein each amplifier includes (i) a first input operatively coupled to a corresponding signal electrode, (ii) an inverting input, and (iii) an output corresponding to a neuromuscular signal channel. The device may comprise one or more buffers configured to tap a voltage at the inverting input of a respective amplifier of the plurality of amplifiers. The device may comprise circuitry configured to operatively couple a plurality of outputs of the plurality of amplifiers to generate a common mode reference signal, wherein the common mode reference signal is provided to the inverting input of one or more amplifiers of the plurality of amplifiers.

Methods, materials and devices that pertain to solid-state gel-free sensor for touch-based rapid physiological and chemical sensing are disclosed. In some embodiments of the disclosed technology, a sensor device includes a substrate, a plurality of first electrodes and a plurality of second electrodes formed over the substrate, a first current collector formed over the substrate and coupled to the plurality of first electrodes at one end of each first electrode, and a second current collector formed over the substrate and coupled to the plurality of second electrodes at one end of each second electrode, wherein the first electrodes and the second electrodes are alternately arranged, and adjacent first and second electrodes are spaced apart from each other by a predetermined distance.

A process of capturing a biopotential signal at a surface of a body includes using a sensor receiver which forms a first signal connection with the body wherein one or more parameters of impedance of the first signal connection are unknown. The biopotential signal is received at an output of a first signal channel having a first transfer function dependent on the one or more unknown first impedance parameters. The biopotential signal is received at an output of a second signal channel having a second transfer function dependent on the one or more unknown first impedance parameters. The process also comprises deriving a set of relations for the biopotential signal based on the transfer function of the first signal channel, the transfer function of the second signal channel, and outputs of the first and second signal channels. The set of relations is solved to determine the captured biopotential signal.

A system for the automatic localization of electrode spatial position on the surface of a conductive body, having a processing unit, which: in response to electrical current injections at first electrodes, acquires voltages measured at second electrodes on the surface of the conductive body; using an electrical impedance model of the conductive body, simulates the electrical current injections at the first electrodes and estimates, for each electrical current injection, a resulting body surface potential on the surface of the conductive body; and performs a combined processing of the voltages measured at the second electrodes and of the estimated body surface potential, in order to determine the locations of the second electrodes on the surface of the conductive body.

A system for the automatic localization of electrode spatial position on the surface of a conductive body, having a processing unit, which: in response to electrical current injections at first electrodes, acquires voltages measured at second electrodes on the surface of the conductive body; using an electrical impedance model of the conductive body, simulates the electrical current injections at the first electrodes and estimates, for each electrical current injection, a resulting body surface potential on the surface of the conductive body; and performs a combined processing of the voltages measured at the second electrodes and of the estimated body surface potential, in order to determine the locations of the second electrodes on the surface of the conductive body.